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European Archives of Oto-Rhino-Laryngology

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30.11.2015 | Otology

Association between the V Leiden G1691A mutation and sudden sensorineural hearing loss in Italian population: a meta-analysis

verfasst von: Jingcheng Shu, Yongfeng Si, Shihua Yin, Meirong He

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 9/2016

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Abstract

Epidemiological studies have reported inconsistent findings on the association between the V Leiden G1691A mutation and sudden sensorineural hearing loss (SSNHL) in Italian population. The aim of this meta-analysis was to clarify this association. PubMed, Embase, and the China National Knowledge Infrastructure (CNKI) were searched up to April 1, 2015. We used STATA12.0 to calculate summary odds ratios (ORs) with 95 % confidence intervals (CIs). Four studies including 958 patients were identified. Pooled data showed no significant association between V Leiden G1691A mutation and risk of SSNHL in Italian population: A vs. G (OR = 1.660, 95 % CI 0.428–6.446, P _OR = 0.464) and AG vs. GG (OR = 1.680, 95 % CI 0.422–6.688, P _OR = 0.462). The present meta-analysis suggests that V Leiden G1691A mutation is not significantly associated with increased risk of SSNHL disease in Italian population. Further large and well-designed studies are needed to confirm this association.

Fusconi M, Chistolini A, Angelosanto N, Pignoloni P, Tombolini M, De Virgilio A, Pagliarella M, de Vincentiis M (2011) Role of genetic and acquired prothrombotic risk factors in genesis of sudden sensorineural hearing loss. Audiol Neurootol 16(3):185–190CrossRefPubMed

Nosrati-Zarenoe R, Arlinger S, Hultcrantz E (2007) Idiopathic sudden sensorineural hearing loss: results drawn from the Swedish national database. Acta Otolaryngol 127(11):1168–1175CrossRefPubMed

De Kleyn A (1944) Sudden complete or partial loss of function of the octavus system in apparently normal persons. Acta Otolaryngol (Stockh) 32:409–429CrossRef

Campbell KCM, Klemens JJ (2000) Sudden hearing loss and autoimmune inner ear disease. J Am Acad Audiol 11:361–367PubMed

Hultcrantz E, Stenquist M, Lyttkens L (1994) Sudden deafness: a retrospective evaluation of dextran therapy. ORL J Otorhinolaryngol Relat Spec 56(3):137–142CrossRefPubMed

Probst R, Tschopp K, Lüdin E, Kellerhals B, Podvinec M, Pfaltz CR (1992) A randomized, double-blind, placebo-controlled study of dextran/pentoxifylline medication in acute acoustic trauma and sudden hearing loss. Acta Otolaryngol 112(3):435–443CrossRefPubMed

Wilson WR, Veltri RW, Laird N, Sprinkle PM (1983) Viral and epidemiologic studies of idiopathic sudden hearing loss. Otolaryngol Head Neck Surg 91(6):653–658CrossRefPubMed

Goodhill V (1971) Sudden deafness and round window rupture. Laryngoscope 81(9):1462–1474CrossRefPubMed

Gross M, Friedman G, Eliashar R, Koren-Morag N, Goldschmidt N, Atta IA, Ben-Yehuda A (2006) Impact of methionine synthase gene and methylenetetrahydrofolate reductase gene polymorphisms on the risk of sudden sensorineural hearing loss. Audiol Neurootol 11(5):287–293CrossRefPubMed

10.

Lee EJ, Cho YJ, Yoon YJ (2010) Methylenetetrahydrofolate reductase C677T gene mutation as risk factor for sudden sensorineural hearing loss: association with plasma homocysteine, folate and cholesterol concentrations. J Laryngol Otol 124(12):1268–1273CrossRefPubMed

11.

Capaccio P, Ottaviani F, Cuccarini V, Bottero A, Schindler A, Cesana BM, Censuales S, Pignataro L (2007) Genetic and acquired prothrombotic risk factors and sudden hearing loss. Laryngoscope 117(3):547–551CrossRefPubMed

12.

Görür K, Tuncer U, Eskandari G, Ozcan C, Unal M, Ozsahinoglu C (2005) The role of factor V Leiden and prothrombin G20210A mutations in sudden sensorineural hearing loss. Otol Neurotol 26(4):599–601CrossRefPubMed

13.

Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, vander Velden PA, Reitsma PH (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369(6475):64–67

14.

Liang J, Wu S, Feng B, Lei S, Luo G, Wang J, Li K, Li X, Xie H, Zhang D, Wang X, Wu K, Miao D, Fan D (2011) Factor V Leiden and inflammatory bowel disease: a systematic review and meta-analysis. J Gastroenterol 46(10):1158–1166CrossRefPubMed

15.

van Langevelde K, Flinterman LE, van Hylckama Vlieg A, Rosendaal FR, Cannegieter SC (2012) Broadening the factor V Leiden paradox: pulmonary embolism and deep-vein thrombosis as 2 sides of the spectrum. Blood 120(5):933–946CrossRefPubMed

16.

Levi M, Schouten M, van’t Veer C, van der Poll T(2011). Factor v Leiden mutation in severe infection and sepsis. Semin Thromb Hemost 37(8):955–960

17.

Cadoni G, Scipione S, Rocca B, Agostino S, La Greca C, Bonvissuto D, Paludetti G (2006) Lack of association between inherited thrombophilic risk factors and idiopathic sudden sensorineural hearing loss in Italian patients. Ann Otol Rhinol Laryngol 115(3):195–200CrossRefPubMed

18.

Fusconi M, Chistolini A, de Virgilio A, Greco A, Massaro F, Turchetta R, Benincasa AT, Tombolini M, de Vincentiis M (2012) Sudden sensorineural hearing loss: a vascular cause? Analysis of prothrombotic risk factors in head and neck. Int J Audiol 51(11):800–805CrossRefPubMed

19.

Marcucci R, Alessandrello Liotta A, Cellai AP, Rogolino A, Berloco P, Leprini E, Pagnini P, Abbate R, Prisco D (2005) Cardiovascular and thrombophilic risk factors for idiopathic sudden sensorineural hearing loss. J Thromb Haemost 3(5):929–934

20.

Little J, Bradley L, Bray MS, Clyne M, Dorman J, Ellsworth DL, Hanson J, Khoury M, Lau J, O’Brien TR, Rothman N, Stroup D, Taioli E, Thomas D, Vainio H, Wacholder S, Weinberg C (2002) Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations. Am J Epidemiol 156:300–310CrossRefPubMed

21.

Wang L, Teng Z, Cai S, Wang D, Zhao X, Yu K (2013) The association between the PPARγ2 Pro12Ala polymorphism and nephropathy susceptibility in type 2 diabetes: a meta-analysis based on 9,176 subjects. Diagn Pathol 8(1):118CrossRefPubMedPubMedCentral

22.

Gong T, Yang M, Qi L, Shen M, Du Y (2013) Association of MCP-1 -2518A/G and -362G/C variants and tuberculosis susceptibility: a meta-analysis. Infect Genet Evol 20:1–7CrossRefPubMed

23.

Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634CrossRefPubMedPubMedCentral

24.

Yu Y, Wang W, Zhai S, Dang S, Sun M (2012) IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review. Mol Biol Rep 39(8):8457–8463CrossRefPubMed

25.

Capaccio P, Ottaviani F, Cuccarini V, Ambrosetti U, Fagnani E, Bottero A, Cenzuales S, Cesana BM, Pignataro L (2005) Methylenetetrahydrofolate reductase gene mutations as risk factors for sudden hearing loss. Am J Otolaryngol 26(6):383–387CrossRefPubMed

26.

van Mens TE, Levi M, Middeldorp S (2013) Evolution of Factor V Leiden. Thromb Haemost 110(1):23–30CrossRefPubMed

27.

De Stefano V, Leone G (1995) Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia. Haematologica 80:344–356PubMed

28.

Baker R, Thom J, van Bockxmeer F (1994) Diagnosis of activated protein C resistance (factor V Leiden). Lancet 344:1162CrossRefPubMed

29.

Zajtchuk JT, Falor WH Jr, Rhodes MF (1979) Hypercoagulability as a cause of sudden neurosensory hearing loss. Otolaryngol Head Neck Surg (1979) 87(2):268–273

30.

Gold S, Kamerer DB, Hirsch BE, Cass SP (1993) Hypercoagulability in otologic patients. Am J Otolaryngol 14(5):327–331CrossRefPubMed

31.

Lovato A, Tormene D, Staffieri C, Breda S, Staffieri A, Marioni G (2014) Sudden hearing loss followed by deep vein thrombosis and pulmonary embolism in a patient with factor V Leiden mutation. Int J Audiol 53(9):625–628

32.

Driul L, Damante G, D’Elia A, Springolo F, Ianni A, Di Leonardo C, Angelini M, Marchesoni D (2004) [Screening for pre-eclampsia in a low-risk population at 24 weeks: uterine artery Doppler flow velocimetry and genetic variants of factor V,prothrombin and methylenetetrahydrofolate reductase]. Minerva Ginecol 56(5):385–390 (Italian)

33.

Santoro N, Colombini A, Silvestri D, Grassi M, Giordano P, Parasole R, Barisone E, Caruso R, Conter V, Valsecchi MG, Masera G, Rizzari C (2013) Screening for coagulopathy and identification of children with acute lymphoblastic leukemia at a higher risk of symptomatic venous thrombosis: an AIEOP experience. J Pediatr Hematol Oncol 35(5):348–355CrossRefPubMed

34.

Barreiro LB, Laval G, Quach H, Patin E, Quintana-Murci L (2008) Natural selection has driven population differentiation in modern humans. Nat Genet 40(3):340–345CrossRefPubMed

Titel: Association between the V Leiden G1691A mutation and sudden sensorineural hearing loss in Italian population: a meta-analysis
verfasst von: Jingcheng Shu
Yongfeng Si
Shihua Yin
Meirong He
Publikationsdatum: 30.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 9/2016
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-015-3844-x

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Association between the V Leiden G1691A mutation and sudden sensorineural hearing loss in Italian population: a meta-analysis

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