The online version of this article (doi:10.1186/s13054-014-0684-9) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
YPZ conceived the study, participated in the design, collected the data, and drafted the manuscript. YDW collected the data, and performed statistical analyses. KQC helped to collect the data. YDW and TWS conceived the study, participated in the design, and helped to draft the manuscript. LXW edited and checked the manuscript. All authors read and approved the final manuscript.
Vitamin D deficiency is common in critically ill patients, and was reported to be associated with adverse outcomes. However, the effect of vitamin D deficiency on mortality in critically ill patients remains unclear.
We searched PubMed and EMBASE from the inception to July 2014 for cohort studies to assess the effect of vitamin D deficiency on the incidence of mortality in critically ill patients. Mortality-specific odds ratio (OR) with 95% confidence interval (CI) were pooled with a random- or fixed-effect models when appropriate.
Seven cohort studies with a total of 4,204 participants including 1,679 cases of vitamin D deficiency were included in this meta-analysis. Vitamin D deficiency was significantly associated with an increased hospital mortality (OR 1.76; 95% CI, 1.38 to 2.24; P <0.001), with very low heterogeneity (I 2 = 2.3%; P = 0.402). The finding of increased hospital mortality in critically ill adult patients was consistently found in every stratum of our subgroup analyses.
This meta-analysis suggests that vitamin D deficiency is associated with increased incidence of hospital mortality in critically ill adult patients.
Additional file 1: Methodological quality assessment (risk of bias) of included studies by Newcastle-Ottawa scales. (DOC 30 KB)13054_2014_684_MOESM1_ESM.doc
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