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Erschienen in: Lung 3/2018

03.03.2018 | ASTHMA

Association Between Vitamin D Metabolism Gene Polymorphisms and Risk of Tunisian Adults’ Asthma

verfasst von: Oussama Lahmar, Mariem Salhi, Wajih Kaabachi, Anissa Berraies, Jamel Ammar, Munawar Hussain Soomro, Martin Larsen, Isabella Annesi-Maesano, Kamel Hamzaoui, Agnes Hamzaoui

Erschienen in: Lung | Ausgabe 3/2018

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Abstract

Introduction

Several studies have shown a strong correlation between the serum vitamin D level and asthma severity and deficits in lung function.

Objective

Study the relationship between vitamin D and the severity of asthma by targeting five SNPs of vitamin D metabolism gene pathway in a Tunisian adult asthmatics population.

Methods

Our case–control study includes 154 adult asthmatic patients and 154 healthy Tunisian subjects. We genotyped many variants in three human genes encoding key components of the vitamin D metabolism, CYP2R1, CYP27B1, GC. The GC gene rs4588 and rs7041 polymorphisms were analysed using the PCR-RFLP method, while rs10741657 and rs12794714 for CYP2R1 gene and rs10877012 of CYP27B1 gene were investigated using TaqMan PCR genotyping techniques.

Results

We found that the presence of at least one copy of the rs12794714 A, allele was associated with lower risk of developing asthma (OR 0.61). Further, the rs12794714 is a protector factor against asthma severity (OR 0.5). However, the presence of rs10877012 TG genotype is a risk factor related to asthma severity (OR 1.89). When we classified the population according to sex, our results showed that rs10877012 TT genotype was a risk factor for women subjects (OR 6.7). Moreover, the expression of TT genotype was associated with a higher risk of asthma in non-smoker patients (OR 7.13). We found a significant lower VD serum levels in asthmatics than controls but no impact of the polymorphisms on VD levels.

Conclusions

We found that rs12794714 and rs10877012 SNPs were associated with asthma risk.
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Metadaten
Titel
Association Between Vitamin D Metabolism Gene Polymorphisms and Risk of Tunisian Adults’ Asthma
verfasst von
Oussama Lahmar
Mariem Salhi
Wajih Kaabachi
Anissa Berraies
Jamel Ammar
Munawar Hussain Soomro
Martin Larsen
Isabella Annesi-Maesano
Kamel Hamzaoui
Agnes Hamzaoui
Publikationsdatum
03.03.2018
Verlag
Springer US
Erschienen in
Lung / Ausgabe 3/2018
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-018-0101-2

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