Background
Methods
Publication search
Inclusion and exclusion criteria
Data extraction
Study quality assessment and meta-analysis quality assessment
Statistical analysis
Results
Meta-analysis of ADRB2 rs1042713 polymorphism and asthma risk
Variable | n | Case/Control | Dominant model comparison | Recessive model comparison | Homozygote genotype comparison | Allelic comparison | Frequency of minor allele (A/(A + G)) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR[95%CI] | P(Z) | I2 | OR[95%CI] | P(Z) | I2 | OR[95%CI] | P(Z) | I2 | OR[95%CI] | P(Z) | I2 | Case | Control | |||
Total | 71 | 12,070/21669 | 1.08 [0.97, 1.21] | 0.165 | 68% | 1.05 [0.94, 1.18] | 0.387 | 70% | 1.10 [0.95, 1.27] | 0.201 | 70% | 1.02 [0.95, 1.10] | 0.591 | 74% | 0.494 | 0.443 |
Adult | 36 | 6984/15697 | 1.12 [0.97, 1.28] | 0.122 | 62% | 1.05 [0.92, 1.19] | 0.447 | 58% | 1.12 [0.96, 1.32] | 0.160 | 56% | 1.06 [0.98, 1.15] | 0.131 | 56% | 0.485 | 0.430 |
Children | 26 | 4539/5320 | 1.13 [0.93, 1.38] | 0.210 | 72% | 1.07 [0.85, 1.35] | 0.570 | 79% | 1.13 [0.85, 1.51] | 0.400 | 79% | 1.00 [0.85, 1.17] | 0.976 | 84% | 0.510 | 0.478 |
East-Asian | 36 | 6343/6291 | 1.00 [0.87, 1.16] | 0.966 | 63% | 1.04 [0.87, 1.26] | 0.645 | 71% | 1.03 [0.84, 1.26] | 0.801 | 67% | 1.02 [0.93, 1.13] | 0.677 | 69% | 0.539 | 0.533 |
Indian | 5 | 1190/1241 | 0.72 [0.59, 0.87] | 0.001 | 25% | 0.91 [0.69, 1.19] | 0.480 | 54% | 0.72 [0.51, 1.03] | 0.070 | 53% | 0.84 [0.69, 1.02] | 0.073 | 60% | 0.477 | 0.437 |
Arab | 2 | 307/361 | 1.75 [1.14, 2.70] | 0.011 | 0% | 1.17 [0.59, 2.30] | 0.654 | 69% | 1.88 [1.17, 3.02] | 0.009 | 35% | 0.83 [0.34, 2.02] | 0.165 | 51% | 0.360 | 0.436 |
Hispanic-Latinos | 5 | 1026/1412 | 1.68 [1.10, 2.55] | 0.016 | 77% | 1.64 [0.86, 3.14] | 0.133 | 90% | 2.09 [0.98, 4.45] | 0.055 | 64% | 0.99 [0.60, 1.63] | 0.970 | 94% | 0.464 | 0.481 |
non-Hispanic Blacks | 5 | 671/556 | 1.55 [0.70, 3.42] | 0.282 | 80% | 1.22 [0.68, 2.19] | 0.498 | 52% | 1.40 [0.64, 3.06] | 0.401 | 64% | 0.70 [0.55, 0.89] | 0.529 | 85% | 0.529 | 0.532 |
Caucasian | 16 | 2892/11950 | 1.05 [0.87, 1.25] | 0.620 | 36% | 0.96 [0.83, 1.11] | 0.541 | 35% | 1.01 [0.87, 1.16] | 0.946 | 32% | 0.99 [0.89, 1.10] | 0.847 | 46% | 0.430 | 0.389 |
HWE(P > 0.05) | 49 | 9752/19296 | 0.99 [0.87, 1.13] | 0.890 | 70% | 0.97 [0.85, 1.10] | 0.598 | 73% | 0.98 [0.81, 1.16] | 0.716 | 76% | 0.98 [0.90, 1.07] | 0.653 | 78% | 0.486 | 0.431 |
HWE(P < 0.05) | 18 | 2366/2320 | 1.22 [0.96, 1.55] | 0.240 | 55% | 1.17 [0.94, 1.44] | 0.164 | 50% | 1.17 [0.99, 1.38] | 0.055 | 29% | 1.15 [1.01, 1.30] | 0.031 | 48% | 0.520 | 0.541 |
Meta-analysis of the ADRB2 rs1042714 polymorphism and asthma risk
Variable | n | Case/Control | Dominant model comparison | Recessive model comparison | Homozygote genotype comparison | Allelic comparison | Frequence of minor allele (G/(G + C)) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR[95%CI] | P(Z) | I2 | OR[95%CI] | P(Z) | I2 | OR[95%CI] | P(Z) | I2 | OR[95%CI] | P(Z) | I2 | Case | Control | |||
Total | 52 | 8242/16832 | 0.92 [0.83, 1.02] | 0.097 | 45% | 0.83 [0.70, 0.98] | 0.032 | 44% | 0.84 [0.72, 0.98] | 0.028 | 25% | 0.91 [0.83, 0.99] | 0.029 | 59% | 0.242 | 0.348 |
Adult | 28 | 5022/13609 | 0.89 [0.77, 1.02] | 0.101 | 55% | 0.94 [0.83, 1.07] | 0.372 | 6% | 0.94 [0.81, 1.08] | 0.371 | 0% | 0.92 [0.83, 1.02] | 0.095 | 52% | 0.246 | 0.371 |
Children | 18 | 2498/2510 | 0.97 [0.81, 1.16] | 0.706 | 36% | 0.59 [0.39, 0.88] | 0.009 | 58% | 0.63 [0.43, 0.92] | 0.016 | 46% | 0.86 [0.69, 1.07] | 0.169 | 73% | 0.205 | 0.234 |
East-Asian | 27 | 4555/4217 | 0.94 [0.85, 1.04] | 0.249 | 20% | 0.81 [0.65, 1.01] | 0.057 | 0% | 0.82 [0.66, 1.03] | 0.090 | 0% | 0.93 [0.85, 1.01] | 0.085 | 25% | 0.164 | 0.161 |
Indian | 3 | 672/687 | 0.85 [0.68, 1.07] | 0.160 | 18% | 1.04 [0.70, 1.54] | 0.862 | 0% | 0.95 [0.63, 1.43] | 0.806 | 0% | 0.91 [0.76, 1.09] | 0.294 | 0% | 0.234 | 0.250 |
Arab | 2 | 137/196 | 0.98 [0.63, 1.51] | 0.249 | 0% | 1.14 [0.49, 2.61] | 0.764 | 0% | 1.11 [0.47, 2.60] | 0.810 | 0% | 1.01 [0.71, 1.43] | 0.972 | 0% | 0.270 | 0.273 |
Hispanic-Latinos | 4 | 605/982 | 0.67 [0.41, 1.10] | 0.108 | 75% | 0.54 [0.13, 2.25] | 0.394 | 90% | 0.54 [0.18, 1.64] | 0.276 | 82% | 0.61 [0.33, 1.15] | 0.129 | 91% | 0.202 | 0.277 |
non-Hispanic Blacks | 2 | 194/162 | 1.06 [0.53, 2.09] | 0.875 | 58% | 0.88 [0.40, 1.94] | 0.758 | 0% | 0.94 [0.41, 2.12] | 0.876 | 0% | 1.03 [0.74, 1.45] | 0.845 | 41% | 0.309 | 0.290 |
Caucasian | 14 | 2079/10588 | 0.98 [0.81, 1.19] | 0.840 | 51% | 0.90 [0.78, 1.03] | 0.126 | 29% | 0.92 [0.79, 1.08] | 0.319 | 11% | 0.94 [0.82, 1.07] | 0.338 | 50% | 0.418 | 0.437 |
HWE(P > 0.05) | 35 | 5552/14306 | 0.89 [0.80, 0.99] | 0.034 | 32% | 0.94 [0.83, 1.06] | 0.299 | 0% | 0.94 [0.81, 1.08] | 0.358 | 0% | 0.91 [0.84, 0.99] | 0.021 | 28% | 0.258 | 0.366 |
HWE(P < 0.05) | 16 | 2478/2474 | 0.95 [0.77, 1.17] | 0.637 | 59% | 0.70 [0.47, 1.06] | 0.089 | 69% | 0.73 [0.51, 1.05] | 0.088 | 58% | 0.87 [0.70, 1.09] | 0.239 | 79% | 0.221 | 0.248 |
Meta-analysis of the ADRB2 rs1042711 polymorphism and asthma risk
Items | Number | ||
---|---|---|---|
Study | 7 | ||
Case | 1769 | ||
Control | 1941 | ||
OR[95%CI] | P(Z) | I2 | |
Dominant model comparison | 0.91 [0.73, 1.14] | 0.433 | 53% |
Recessive model comparison | 1.24 [0.89, 1.74] | 0.200 | 3% |
Homozygote genotype comparison | 1.21 [0.86, 1.71] | 0.271 | 9% |
Allelic comparison | 0.95 [0.78, 1.18] | 0.665 | 61% |
Frequence of minor allele (C/(T + C)) | |||
Case | 0.170 | ||
Control | 0.170 |
Publication bias
SNP | Study number | Dominant model comparison | Recessive model comparison | Homozygote genotype comparison | Allelic comparison | ||||
---|---|---|---|---|---|---|---|---|---|
t | p | t | p | t | p | t | p | ||
rs1042713 | 71 | 0.520 | 0.603 | 0.250 | 0.801 | 0.430 | 0.665 | 0.460 | 0.650 |
rs1042714 | 52 | 1.300 | 0.200 | 0.270 | 0.791 | 0.460 | 0.646 | 0.510 | 0.609 |
rs1042711 | 7 | −0.110 | 0.916 | −2.460 | 0.058 | −2.560 | 0.050 | −0.520 | 0.622 |