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Journal of Assisted Reproduction and Genetics

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27.05.2016 | Genetics

Association of a TDRD1 variant with spermatogenic failure susceptibility in the Han Chinese

verfasst von: Xiao-Bin Zhu, Jian-Qi Lu, Er-Lei Zhi, Yong Zhu, Sha-Sha Zou, Zi-Jue Zhu, Feng Zhang, Zheng Li

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 8/2016

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Abstract

Purpose

Piwi-interacting RNAs (piRNAs) are a broad group of noncoding small RNAs that have important biological functions in germline cells and can maintain genome integrity via silencing of retrotransposons. In this study, we aimed to explore the associations between genetic variants of important genes involved in piRNA biogenesis and male infertility with spermatogenic impairment.

Methods

To this end, five single-nucleotide polymorphisms (SNPs) in the ASZ1, PIWIL1, TDRD1, and TDRD9 genes were genotyped by TaqMan allelic discrimination assays in 342 cases of nonobstructive azoospermia (NOA) and 493 controls.

Results

The SNP rs77559927 in TDRD1 was associated with a reduced risk of spermatogenic impairment. The genotypes TC and TC + CC showed odds ratios and 95 % confidence intervals of 0.73 (0.55–0.98, P = 0.034) and 0.73 (0.56–0.97, P = 0.030), respectively, in patients with NOA compared with those in the controls.

Conclusion

Thus, our results provided the first epidemiological evidence supporting the involvement of TDRD1 genetic polymorphisms in piRNA processing genes in determining the risk of spermatogenic impairment in a Han Chinese population.

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Titel: Association of a TDRD1 variant with spermatogenic failure susceptibility in the Han Chinese
verfasst von: Xiao-Bin Zhu
Jian-Qi Lu
Er-Lei Zhi
Yong Zhu
Sha-Sha Zou
Zi-Jue Zhu
Feng Zhang
Zheng Li
Publikationsdatum: 27.05.2016
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 8/2016
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-016-0738-9

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Association of a TDRD1 variant with spermatogenic failure susceptibility in the Han Chinese

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Results

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