Association of Albumin-Bilirubin Grade and Myosteatosis with its Prognostic Significance for Patients with Colorectal Cancer
- 24.02.2022
- Colorectal Cancer
Erschienen in:
- Verfasst von
- Hwa-Hee Koh, M.D.
- Eun-Suk Cho, M.D., Ph.
- Jae-Hoon Lee, M.D., Ph.D.
- Su-Jin Shin, M.D., Ph.D.
- Hye Sun Lee, Ph.D.
- Eun Jung Park, M.D., Ph.D.
- Seung Hyuk Baik, M.D., Ph.D.
- Kang Young Lee, M.D., Ph.D.
- Jeonghyun Kang, M.D., Ph.D.
- Erschienen in
- Annals of Surgical Oncology | Ausgabe 6/2022
Abstract
Background
The albumin-bilirubin (ALBI) grade is a useful prognostic and predictive marker for patients with liver disease. Its clinical significance has been limited to patients with colorectal cancer (CRC). Furthermore, the association between the ALBI grade and skeletal muscle-related indices is unclear.
Methods
This study enrolled 1015 patients who underwent computed tomography (CT) scans within 31 days before surgery. The prognostic value of the ALBI grade in predicting overall survival (OS) was assessed using the Cox proportional hazards model. The correlation between the ALBI grade and the skeletal muscle index or radiodensity (myosteatosis) was evaluated. The predictive accuracy of ALBI alone and in combination with myosteatosis was compared using Harrell’s concordance index (C-index).
Results
The significant prognostic factors for OS identified in the multivariable analysis were the ALBI group (low vs high: hazard ratio [HR], 1.566; 95 % confidence interval [CI], 1.174–2.089; p = 0.002) and myosteatosis (low vs. high: HR, 0.648; 95 % CI, 0.486–0.865; p = 0.003). The rate of low-grade myosteatosis increased as the ALBI grade increased. The C-index of combined ALBI and myosteatosis (0.650; 95 % CI, 0.618–0.683) was superior to that of ALBI alone (0.603; 95 % CI, 0.575–0.631; bootstrap incremental area under the curve [iAUC] mean difference, 0.047; 95 % CI, 0.012–0.070) and myosteatosis alone (0.608; 95 % CI, 0.577–0.640; bootstrap iAUC mean difference, 0.042; 95 % CI, 0.023–0.064).
Conclusion
The ALBI grade is significantly associated with myosteatosis. The ALBI grade is a significant prognostic factor, and the combination of ALBI and myosteatosis show an additive value in discriminating survival of patients with CRC.
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- Titel
- Association of Albumin-Bilirubin Grade and Myosteatosis with its Prognostic Significance for Patients with Colorectal Cancer
- Verfasst von
-
Hwa-Hee Koh, M.D.
Eun-Suk Cho, M.D., Ph.
Jae-Hoon Lee, M.D., Ph.D.
Su-Jin Shin, M.D., Ph.D.
Hye Sun Lee, Ph.D.
Eun Jung Park, M.D., Ph.D.
Seung Hyuk Baik, M.D., Ph.D.
Kang Young Lee, M.D., Ph.D.
Jeonghyun Kang, M.D., Ph.D.
- Publikationsdatum
- 24.02.2022
- Verlag
- Springer International Publishing
- Erschienen in
-
Annals of Surgical Oncology / Ausgabe 6/2022
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681 - DOI
- https://doi.org/10.1245/s10434-022-11445-z
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