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Journal of Medical Ultrasonics
Erschienen in:

16.07.2022 | Original Article–Obstetrics & Gynecology

Association of amniotic fluid natriuretic peptide levels with ductus venosus Doppler flow in recipient twins with twin-to-twin transfusion syndrome

DV flow and NT-proBNP in TTTS recipient twins

verfasst von: Mayumi Takano, Sumito Nagasaki, Junya Sakuma, Makiko Shimabukuro, Hikari Kotaki, Masahiko Nakata

Erschienen in: Journal of Medical Ultrasonics | Ausgabe 4/2022

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Abstract

Purpose

This study examined the relationships between fetal quantitative Doppler parameters and amniotic fluid N-terminal prohormone brain natriuretic peptide (afNT-proBNP) levels as a biomarker of the increased cardiac load in recipient twins with twin-to-twin transfusion syndrome (TTTS).

Methods

This single-center, prospective study included all monochorionic diamniotic (MD) twin pregnancies that were diagnosed with TTTS and underwent fetoscopic laser surgery. Doppler flow was used to measure the pulsatility index (PI) of the umbilical artery (UA), ductus venosus (DV), and middle cerebral artery (MCA) of each recipient and donor twins. The afNT-proBNP levels of recipient twins were examined at the time of surgery. The Spearman or Pearson correlation coefficients were used to assess the relationships between afNT-proBNP levels and Doppler parameters.

Results

A total of 150 MD twin pregnancies were included. The afNT-proBNP levels of the recipient twins showed a stronger correlation with the DV-PI (r = 0.637; P < 0.001) of recipient twins than with the UA-PI and MCA-PI of recipient twins. The Doppler parameters of donor twins were scarcely correlated with the afNT-proBNP levels of the recipient twins.

Conclusion

A positive correlation between the DV-PI and afNT-proBNP levels of recipient twins with TTTS was observed. The recipient twin with an increased DV-PI is expected to be under a high cardiac load; therefore, DV-PI is a useful parameter for assessing increased NT-proBNP levels consecutively and noninvasively.

Clinical Trial Registration

This study was registered with Japanese Clinical Trial Registry “UMIN-CTR” (http://​www.​umin.​ac.​jp/​ctr/​index-j.​htm; trial ID numbers UMIN000024486 and 000037702).
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Metadaten
Titel
Association of amniotic fluid natriuretic peptide levels with ductus venosus Doppler flow in recipient twins with twin-to-twin transfusion syndrome
DV flow and NT-proBNP in TTTS recipient twins
verfasst von
Mayumi Takano
Sumito Nagasaki
Junya Sakuma
Makiko Shimabukuro
Hikari Kotaki
Masahiko Nakata
Publikationsdatum
16.07.2022
Verlag
Springer Nature Singapore
Erschienen in
Journal of Medical Ultrasonics / Ausgabe 4/2022
Print ISSN: 1346-4523
Elektronische ISSN: 1613-2254
DOI
https://doi.org/10.1007/s10396-022-01241-3

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