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01.11.2010 | Regular Article | Ausgabe 6/2010

Environmental Health and Preventive Medicine 6/2010

Association of body mass index with risk of age-related cataracts in a middle-aged Japanese population: the JPHC Study

Zeitschrift:
Environmental Health and Preventive Medicine > Ausgabe 6/2010
Autoren:
Masao Yoshida, Manami Inoue, Motoki Iwasaki, Shoichiro Tsugane, JPHC Study Group
Wichtige Hinweise
The members of the JPHC Study Group is given in the Appendix.

Abstract

Objectives

Many epidemiological studies have demonstrated that body mass index (BMI) is associated with the risk of developing age-related cataracts. These reports have suggested that high and low BMIs can affect the onset or progression of age-related visual impairment. However, few prospective studies have examined this relationship in a general Asian population. Therefore, in this study, we investigated whether BMI was associated with an increased risk of age-related cataracts by performing a 5-year prospective population-based study in a middle-aged Japanese population.

Methods

This 5-year population-based study included 35,365 men and 40,825 women (aged 45–74 years), who were recruited into the Japan Public Health Center (JPHC)-based Prospective Study and had not reported cataracts in a baseline survey. The self-reported diagnosis of age-related cataracts was used in the analysis of this study.

Results

At follow up, 1,004 men (2.84%) and 1,807 women (4.43%) reported new diagnoses of age-related cataracts. The multivariate odds ratios (ORs) for those in the lowest and the highest BMI categories, compared with a BMI category of 21.0–22.9 as a reference point (OR, 1.00), were 1.29 [95% confidence interval (CI) 0.93–1.79] and 1.15 (95% CI 0.96–1.39) in men, and 1.23 (95% CI 0.97–1.55) and 1.19 (95% CI 1.04–1.36) in women.

Conclusions

Previous studies have suggested high BMI as a risk factor of age-related cataracts for Caucasian populations in developed countries while low BMI for populations living in developing countries. In contrast to those studies, the present large-cohort study showed a U-shaped association between BMI and the incidence of cataracts in Japanese men and women.

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