Association of C-peptide level with bone mineral density in type 2 diabetes mellitus
- 19.05.2023
- Original Article
Erschienen in:
- Verfasst von
- Hong Yang
- Jia Bai
- Lingling Li
- Ying Yang
- Yangyang Zhang
- Haihong Lv
- Songbo Fu
- Erschienen in
- Osteoporosis International | Ausgabe 8/2023
Abstract
Summary
This study revealed that there was no significant linear relationship between fasting C-peptide (FCP) level and bone mineral density (BMD) or fracture risk in type 2 diabetes mellitus (T2DM) patients. However, in the FCP ≤ 1.14 ng/ml group, FCP is positively correlated with whole body (WB), lumbar spine (LS), and femoral neck (FN) BMD and negatively correlated with fracture risk.
Purpose
To explore the relationship between C-peptide and BMD and fracture risk in T2DM patients.
Methods
530 T2DM patients were enrolled and divided into three groups by FCP tertiles, and the clinical data were collected. BMD was measured by dual-energy X-ray absorptiometry (DXA). The 10-year probability of major osteoporotic fractures (MOFs) and hip fractures (HFs) was evaluated by adjusted fracture risk assessment tool (FRAX).
Results
In the FCP ≤ 1.14 ng/ml group, FCP level was positively correlated with WB, LS, and FN BMD, while FCP was negatively correlated with fracture risk and osteoporotic fracture history. However, FCP was not correlated with BMD and fracture risk and osteoporotic fracture history in the 1.14 < FCP ≤ 1.73 ng/ml and FCP > 1.73 ng/ml groups. The study has shown that FCP was an independent factor influencing BMD and fracture risk in the FCP ≤ 1.14 ng/ml group.
Conclusions
There is no significant linear relationship between FCP level and BMD or fracture risk in T2DM patients. In the FCP ≤ 1.14 ng/ml group, FCP is positively correlated with WB, LS, and FN BMD and negatively correlated with fracture risk, and FCP is an independent influencing factor of BMD and fracture risk. The findings suggest that FCP may predict the risk of osteoporosis or fracture in some T2DM patients, which has a certain clinical value.
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- Titel
- Association of C-peptide level with bone mineral density in type 2 diabetes mellitus
- Verfasst von
-
Hong Yang
Jia Bai
Lingling Li
Ying Yang
Yangyang Zhang
Haihong Lv
Songbo Fu
- Publikationsdatum
- 19.05.2023
- Verlag
- Springer London
- Erschienen in
-
Osteoporosis International / Ausgabe 8/2023
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965 - DOI
- https://doi.org/10.1007/s00198-023-06785-9
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