Skip to main content
main-content

16.03.2016 | Original Article | Ausgabe 6/2016

Virchows Archiv 6/2016

Association of coexisting morphological umbilical cord abnormality and clinical cord compromise with hypoxic and thrombotic placental histology

Zeitschrift:
Virchows Archiv > Ausgabe 6/2016
Autor:
Jerzy Stanek
Wichtige Hinweise
Presented at the Congress of European Society of Pathology, 5–9 September 2015, Belgrade, Serbia

Abstract

To assess the usefulness and limitations of placental histology when morphological umbilical cord (UC) abnormality coexists with clinical UC compromise, 5634 consecutive placentas were divided into four groups and statistically compared: group 1—182 placentas from pregnancies with clinical features of UC compromise (variable decelerations, UC entanglement, prolapse, or true knot at delivery); group 2—1355 placentas with abnormal UC morphology or insertion; group 3—152 placentas with at least one phenotype from group 1 and one from group 2; group 4—3945 placentas with no clinical or morphological UC-related phenotypes (control group).Differences were analyzed by ANOVA or χ 2. Of 68 phenotypes studied, 13 clinical and 18 placental phenotypes were statistically significant. In group 1, 2 phenotypes were most common (oligohydramnios and abnormal fetal heart rate tracing). In group 2, 6 phenotypes were most common, including 4 clinical (abnormal umbilical artery Dopplers, nonmacerated stillbirth, multiple pregnancy, and fetal growth restriction) and 2 placental. In group 3, 23 phenotypes were most common, including 7 clinical (gestational hypertension, polyhydramnios, induction of labor, cesarean section, macerated stillbirth, congenital malformations, and abnormal 3rd stage of labor) and 16 placental. The existence of clinical signs of UC compromise alone was associated with the absence of pathomorphological placental abnormalities. However, the coexistence of clinical and abnormal morphological UC phenotypes was statistically significantly associated with placental histological signs of decreased fetal blood flow, hypoxia (acute and chronic post uterine), shallow placental implantation, and/or amnion nodosum. Thus, confirmation of clinical UC compromise should not be expected on placental examination if no morphological UC abnormality or abnormal UC insertion has been found.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Jetzt bestellen und 50 € OTTO-Gutschein sichern!

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 6/2016

Virchows Archiv 6/2016 Zur Ausgabe

Editorial

In this issue

Neu im Fachgebiet Pathologie

27.11.2018 | Hauptreferate: Tumorevolution II | Sonderheft 2/2018

Zirkulierende Tumorzellen beim Pankreaskarzinom

Ergebnisse morphologischer und molekularer Analysen und Vergleiche mit dem Primärtumor

23.11.2018 | Hauptreferate: Hauptprogramm der DGP | Sonderheft 2/2018

Das Urachuskarzinom – aktuelle Konzepte einer seltenen Tumorerkrankung

16.11.2018 | Hauptreferate: Hauptprogramm der DGP | Sonderheft 2/2018

Das Deutsche Mesotheliomregister

Aktuelle pathologische Diagnostik und Leistungen

14.11.2018 | Originalien | Ausgabe 6/2018

Retinale Blutungen beim Schütteltrauma

Differenzialdiagnostische Aspekte


 

Bildnachweise