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01.03.2012 | Basic Neurosciences, Genetics and Immunology - Short communication | Ausgabe 3/2012

Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults

Zeitschrift:: Journal of Neural Transmission > Ausgabe 3/2012

Autoren:: Daimei Sasayama, Hiroaki Hori, Toshiya Teraishi, Kotaro Hattori, Miho Ota, Junko Matsuo, Yumiko Kawamoto, Yukiko Kinoshita, Naoji Amano, Hiroshi Kunugi

Abstract

Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.

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Titel: Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults
Autoren:: Daimei Sasayama
Hiroaki Hori
Toshiya Teraishi
Kotaro Hattori
Miho Ota
Junko Matsuo
Yumiko Kawamoto
Yukiko Kinoshita
Naoji Amano
Hiroshi Kunugi
Publikationsdatum: 01.03.2012
DOI: https://doi.org/10.1007/s00702-011-0709-3
Verlag: Springer Vienna
Zeitschrift: Journal of Neural Transmission Translational Neuroscience, Neurology and Preclinical Neurological Studies, Psychiatry and Preclinical Psychiatric Studies
Ausgabe 3/2012
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463

Sie können e.Med Neurologie & Psychiatrie 14 Tage kostenlos testen (keine Print-Zeitschrift enthalten). Der Test läuft automatisch und formlos aus. Es kann nur einmal getestet werden.
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Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults

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