nach oben

Erschienen in:

15.07.2019 | Original Contribution

Association of dietary nitrate intake with retinal microvascular structure in older adults

verfasst von: Bamini Gopinath, Gerald Liew, Joshua R. Lewis, Lauren C. Blekkenhorst, Catherine Bondonno, George Burlutsky, Jonathan M. Hodgson, Paul Mitchell

Erschienen in: European Journal of Nutrition | Ausgabe 5/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Existing research suggests that changes to retinal vascular caliber reflect nitric oxide (NO)-dependent endothelial dysfunction. Dietary nitrate is an important source of NO; however, studies on the link between dietary nitrate intake and retinal microvasculature are lacking. We aimed to assess the cross-sectional association between intake of dietary nitrate (from vegetable and non-vegetable sources) and retinal arteriolar and venular caliber among older adults.

Methods

Participants from the Blue Mountains Eye Study aged 49+ years with complete data at baseline on diet and retinal vessel measures were analyzed (n = 2813). Dietary intake was assessed using a validated semi-quantitative food-frequency questionnaire. Nitrate intake from vegetable and non-vegetable sources was estimated using a validated comprehensive database and other published data where necessary. Fundus photographs were taken and retinal vascular caliber measured using validated computer-assisted techniques and summarized.

Results

Participants in the lowest versus highest tertile of vegetable nitrate intake had significantly narrower retinal arterioles: 186.2 ± 0.48 versus 187.6 ± 0.48 µm (multivariable-adjusted p = 0.04). After multivariable adjustment, each 10-unit higher intake of total nitrate and vegetable nitrate was associated with 0.089 ± 0.004 and 0.090 ± 0.004 µm wider retinal arteriolar caliber, respectively, both p = 0.03. Each 10-unit higher vegetable nitrate intake was associated with 0.092 ± 0.005 µm narrower retinal venules (p = 0.05).

Conclusion

Intake of dietary nitrate, particularly from vegetable sources, was associated with beneficial variations in both retinal arteriolar and venular caliber among older adults. Further research into associations between dietary nitrate and the retinal microvasculature could allow for greater understanding and possible prevention of clinical cardiovascular events.

Nur mit Berechtigung zugänglich

Cheung N, Saw SM, Islam FM, Rogers SL, Shankar A, de Haseth K, Mitchell P, Wong TY (2007) BMI and retinal vascular caliber in children. Obesity (Silver Spring) 15:209–215CrossRef

Gopinath B, Flood VM, Wang JJ, Burlutsky G, Mitchell P (2013) Lower dairy products and calcium intake is associated with adverse retinal vascular changes in older adults. Nutr Metab Cardiovasc, Dis

Dumitrascu OM, Demaerschalk BM, Valencia SC, Almader-Douglas D, O’Carroll CB, Aguilar MI, Lyden PD, Kumar G (2018) Retinal microvascular abnormalities as surrogate markers of cerebrovascular ischemic disease: a meta-analysis. J Stroke Cerebrovasc Dis 27:1960–1968CrossRef

Hughes AD, Falaschetti E, Witt N, Wijetunge S, Thom SA, Tillin T, Aldington SJ, Chaturvedi N (2016) Association of retinopathy and retinal microvascular abnormalities with stroke and cerebrovascular disease. Stroke 47:2862–2864CrossRef

Gopinath B, Chiha J, Plant AJ, Thiagalingam A, Burlutsky G, Kovoor P, Liew G, Mitchell P (2014) Associations between retinal microvascular structure and the severity and extent of coronary artery disease. Atherosclerosis 236:25–30CrossRef

Sun C, Wang JJ, Mackey DA, Wong TY (2009) Retinal vascular caliber: systemic, environmental, and genetic associations. Surv Ophthalmol 54:74–95CrossRef

Hobbs DA, George TW, Lovegrove JA (2013) The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies. Nutr Res Rev 26:210–222CrossRef

Bondonno CP, Croft KD, Hodgson JM (2016) Dietary nitrate, nitric oxide, and cardiovascular health. Crit Rev Food Sci Nutr 56:2036–2052CrossRef

Bondonno CP, Blekkenhorst LC, Prince RL, Ivey KL, Lewis JR, Devine A, Woodman RJ, Lundberg JO, Croft KD, Thompson PL, Hodgson JM (2017) Association of vegetable nitrate intake with carotid atherosclerosis and ischemic cerebrovascular disease in older women. Stroke 48:1724–1729CrossRef

10.

Blekkenhorst LC, Bondonno CP, Lewis JR, Devine A, Woodman RJ, Croft KD, Lim WH, Wong G, Beilin LJ, Prince RL, Hodgson JM (2017) Association of dietary nitrate with atherosclerotic vascular disease mortality: a prospective cohort study of older adult women. Am J Clin Nutr 106:207–216CrossRef

11.

Blekkenhorst LC, Bondonno NP, Liu AH, Ward NC, Prince RL, Lewis JR, Devine A, Croft KD, Hodgson JM, Bondonno CP (2018) Nitrate, the oral microbiome, and cardiovascular health: a systematic literature review of human and animal studies. Am J Clin Nutr 107:504–522CrossRef

12.

Gopinath B, Flood VM, Wang JJ, Smith W, Rochtchina E, Louie JC, Wong TY, Brand-Miller J, Mitchell P (2012) Carbohydrate nutrition is associated with changes in the retinal vascular structure and branching pattern in children. Am J Clin Nutr 95:1215–1222CrossRef

13.

Kaushik S, Wang JJ, Wong TY, Flood V, Barclay A, Brand-Miller J, Mitchell P (2009) Glycemic index, retinal vascular caliber, and stroke mortality. Stroke 40:206–212CrossRef

14.

Attebo K, Mitchell P, Smith W (1996) Visual acuity and the causes of visual loss in Australia. The Blue Mountains Eye Study. Ophthalmology 103:357–364CrossRef

15.

Willett WC, Sampson L, Browne ML, Stampfer MJ, Rosner B, Hennekens CH, Speizer FE (1988) The use of a self-administered questionnaire to assess diet four years in the past. Am J Epidemiol 127:188–199CrossRef

16.

Foster-Powell K, Holt SH, Brand-Miller JC (2002) International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76:5–56CrossRef

17.

McLennan W (1995) Australian Statistician. National Nutrition Survey, Confidentialised Unit Record File. (4807.0). Australian Bureau of Statistics, Canberra

18.

Blekkenhorst LC, Prince RL, Ward NC, Croft KD, Lewis JR, Devine A, Shinde S, Woodman RJ, Hodgson JM, Bondonno CP (2017) Development of a reference database for assessing dietary nitrate in vegetables. Mol Nutr Food Res 61:1600982CrossRef

19.

Inoue-Choi M, Virk-Baker MK, Aschebrook-Kilfoy B, Cross AJ, Subar AF, Thompson FE, Sinha R, Ward MH (2016) Development and calibration of a dietary nitrate and nitrite database in the NIH-AARP Diet and Health Study. Public Health Nutr 19:1934–1943CrossRef

20.

Food Standards Australia New Zealand (2011) Survey of nitrates and nitrites in food and beverages in Australia 2011

21.

Griesenbeck JS, Steck MD, Huber JC Jr, Sharkey JR, Rene AA, Brender JD (2009) Development of estimates of dietary nitrates, nitrites, and nitrosamines for use with the Short Willet Food Frequency Questionnaire. Nutr J 8:16CrossRef

22.

Gopinath B, Liew G, Kifley A, Lewis JR, Bondonno C, Joachim N, Hodgson JM, Mitchell P (2018) Association of dietary nitrate intake with the 15-year incidence of age-related macular degeneration. J Acad Nutr Diet 118:2311–2314CrossRef

23.

Wang JJ, Mitchell P, Leung H, Rochtchina E, Wong TY, Klein R (2003) Hypertensive retinal vessel wall signs in a general older population: the Blue Mountains Eye Study. Hypertension 42:534–541CrossRef

24.

Hubbard LD, Brothers RJ, King WN, Clegg LX, Klein R, Cooper LS, Sharrett AR, Davis MD, Cai J (1999) Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology 106:2269–2280CrossRef

25.

Sherry LM, Wang JJ, Rochtchina E, Wong T, Klein R, Hubbard L, Mitchell P (2002) Reliability of computer-assisted retinal vessel measurement in a population. Clin Exp Ophthalmol 30:179–182CrossRef

26.

Wright S (1934) The method of path coefficients. Annals of Mathematical Statistics 5:161–215CrossRef

27.

Willett W (1990) Reproducibility and validity of food-frequency questionnaires. In: Willett W (ed) Nutritional epidemiology. Oxford Univ Press, Oxford, pp 92–126

28.

Willett W, Stampfer MJ (1986) Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 124:17–27CrossRef

29.

Liew G, Wang JJ, Mitchell P, Wong TY (2008) Retinal vascular imaging: a new tool in microvascular disease research. Circ Cardiovasc Imaging 1:156–161CrossRef

30.

McGeechan K, Liew G, Macaskill P, Irwig L, Klein R, Klein BE, Wang JJ, Mitchell P, Vingerling JR, Dejong PT, Witteman JC, Breteler MM, Shaw J, Zimmet P, Wong TY (2009) Meta-analysis: retinal vessel caliber and risk for coronary heart disease. Ann Intern Med 151:404–413CrossRef

31.

Ikram MK, de Jong FJ, Bos MJ, Vingerling JR, Hofman A, Koudstaal PJ, de Jong PT, Breteler MM (2006) Retinal vessel diameters and risk of stroke: the Rotterdam Study. Neurology 66:1339–1343CrossRef

32.

Nguyen TT, Islam FM, Farouque HM, Klein R, Klein BE, Cotch MF, Herrington DM, Wong TY (2010) Retinal vascular caliber and brachial flow-mediated dilation: the multi-ethnic study of atherosclerosis. Stroke 41:1343–1348CrossRef

33.

Nguyen TT, Kawasaki R, Kreis AJ, Wang JJ, Shaw J, Vilser W, Wong TY (2009) Correlation of light-flicker-induced retinal vasodilation and retinal vascular caliber measurements in diabetes. Invest Ophthalmol Vis Sci 50:5609–5613CrossRef

34.

Wong TY, Islam FM, Klein R, Klein BE, Cotch MF, Castro C, Sharrett AR, Shahar E (2006) Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci 47:2341–2350CrossRef

35.

Micha R, Wallace SK, Mozaffarian D (2010) Red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis. Circulation 121:2271–2283CrossRef

36.

Xie L, Mo M, Jia HX, Liang F, Yuan J, Zhu J (2016) Association between dietary nitrate and nitrite intake and sitespecific cancer risk: evidence from observational studies. Oncotarget 7:56915–56932CrossRef

37.

Grosse Y, Baan R, Straif K, Secretan B, El Ghissassi F, Cogliano V (2006) Carcinogenicity of nitrate, nitrite, and cyanobacterial peptide toxins. Lancet Oncol 7:628–629CrossRef

38.

Habermeyer M, Roth A, Guth S, Diel P, Engel KH, Epe B, Furst P, Heinz V, Humpf HU, Joost HG, Knorr D, de Kok T, Kulling S, Lampen A, Marko D, Rechkemmer G, Rietjens I, Stadler RH, Vieths S, Vogel R, Steinberg P, Eisenbrand G (2015) Nitrate and nitrite in the diet: how to assess their benefit and risk for human health. Mol Nutr Food Res 59:106–128CrossRef

39.

Ikram MK, de Jong FJ, Vingerling JR, Witteman JC, Hofman A, Breteler MM, de Jong PT (2004) Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study. Invest Ophthalmol Vis Sci 45:2129–2134CrossRef

40.

Knudtson MD, Klein BE, Klein R, Wong TY, Hubbard LD, Lee KE, Meuer SM, Bulla CP (2004) Variation associated with measurement of retinal vessel diameters at different points in the pulse cycle. Br J Ophthalmol 88:57–61CrossRef

41.

Lanigan LP, Clark CV, Hill DW (1988) Retinal circulation responses to systemic autonomic nerve stimulation. Eye 2:412–417CrossRef

42.

Gopinath B, Wang JJ, Flood VM, Burlutsky G, Wong TY, Mitchell P (2009) The associations between blood levels of homocysteine, folate, vitamin B12, and retinal vascular caliber. Am J Ophthalmol 148:902–909CrossRef

Titel: Association of dietary nitrate intake with retinal microvascular structure in older adults
verfasst von: Bamini Gopinath
Gerald Liew
Joshua R. Lewis
Lauren C. Blekkenhorst
Catherine Bondonno
George Burlutsky
Jonathan M. Hodgson
Paul Mitchell
Publikationsdatum: 15.07.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 5/2020
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-02055-9

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

16.04.2024 | Chronische Herzinsuffizienz | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Association of dietary nitrate intake with retinal microvascular structure in older adults

Abstract

Purpose

Methods

Results

Conclusion

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Sind Betablocker auch für ältere herzschwache Personen nützlich?

Kein Abstrich bei chronischen Wunden ohne Entzündungszeichen!

Manche Gestagene können das Risiko für Meningeome erhöhen

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Innere Medizin

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2020

Estimation and consumption pattern of free sugar intake in 3-year-old Irish preschool children

Human milk and infant formula differentially alters the microbiota composition and functional gene relative abundance in the small and large intestines in weanling rats

Effects of spirulina and wakame consumption on intestinal cholesterol absorption and serum lipid concentrations in non-hypercholesterolemic adult men and women

Association between carbohydrate intake and fatty acids in the de novo lipogenic pathway in serum phospholipids and adipose tissue in a population of Swedish men

Efficacy of F-100, diluted F-100, and infant formula as rehabilitation diet for infants aged < 6 months with severe acute malnutrition: a randomized clinical trial

The effect of a low-carbohydrate high-fat diet and ethnicity on daily glucose profile in type 2 diabetes determined by continuous glucose monitoring

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Sind Betablocker auch für ältere herzschwache Personen nützlich?

Kein Abstrich bei chronischen Wunden ohne Entzündungszeichen!

Manche Gestagene können das Risiko für Meningeome erhöhen

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Innere Medizin