Gestational diabetes mellitus (GDM) is the most popular metabolic disease during pregnancy. The aim of the present study was to investigate any possible association between eNOS Glu298Asp and ACE I/D gene polymorphisms and the risk of GDM in a group of Iranian pregnant women.
In this case-control study 204 pregnant women were recruited (94 cases and 110 controls). Genomic DNA was isolated from whole blood and genotyping was performed by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR- RFLP) and only PCR for eNOS and ACE polymorphisms respectively.
Frequencies of GT and TT genotype of eNOS polymorphism among women with and without GDM were 67.90% vs. 74.47 and 7.41% vs. 8.51% respectively (P = 0.4). Corresponding figures for DD genotype of ACE polymorphism among GDM patients was more than that in healthy women (51.65% vs. 63.81% respectively). Conversely, ACE heterozygote genotype was more common in diabetic women (35.16% vs. 26.67% respectively). Although these differences were not statistically significant (P = 0.2).
Our study showed that there is no association between the presence of eNOS and ACE gene polymorphisms and developing gestational diabetes mellitus among pregnant women in our population. Further longitudinal and multicenter studies should be carried out to assess the exact metabolic effects of these polymorphisms.
Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten
Zhang Y, Sun C-M, Hu X-Q, Zhao Y. Relationship between melatonin receptor 1B and insulin receptor substrate 1 polymorphisms with gestational diabetes mellitus: a systematic review and meta-analysis. Sci Rep 2014;4:6113.
Kamana K, Shakya S, Zhang H. Gestational diabetes mellitus and macrosomia: a literature review. Ann Nutr Metab. 2015;66(Suppl. 2):14–20.
Marsden PA, Heng H, Scherer S, Stewart R, Hall A, Shi X, et al. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem. 1993;268(23):17478–88. PubMed
Baudin B. Angiotensin II receptor polymorphisms in hypertension. Pharmacogenomic Considerations Pharmacogenomics. 2002;3(1):65–73. PubMed
Haijuan H, Fan Z, Meilin Z, Guifen C, Haiyun H, Pinff H. Relationship between endothelial nitric oxide synthase Glu298Asp gene polymorphisms and the chronic periodontitis with type 2 diabetes mellitus. Hua Xi Kou Qiang Yi Xue Za Zhi. 2012;30(6):628–31.
Liyun L, Songbiao L, Chengshan W, Xiufang L. Left ventricular diastolic dysfunction and obesity: a systematic review and meta-analysis of echocardiographic studies. International Journal of Cardiovascular and Cerebrovascular Disease. 2016;4(3):27–34.
Dostálová Z, Bienertová-Vasků A, Vasků A, Gerychová R, Unzeitig V. Insertion-deletion polymorphism in the gene for angiotensin-converning enzyme (I/D ACE) in pregnant women with gestational diabetes. Ceska Gynekol. 2006;71(5):369–73. PubMed
- Association of eNOS and ACE gene polymorphisms as a genetic risk factor in gestational diabetes in Iranian women
Ali Bani Sheykheslam
- Springer International Publishing
Journal of Diabetes & Metabolic Disorders
Elektronische ISSN: 2251-6581
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
e.Med Kampagnen-Visual, Mail Icon II