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Erschienen in: Diabetology International 1/2022

23.07.2021 | Original Article

Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women

verfasst von: Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Kaori Kitaoka, Mika Takeuchi, Megumu Yano, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo

Erschienen in: Diabetology International | Ausgabe 1/2022

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Abstract

Objective

We suggested association of family history of type 2 diabetes (FHD) with microvascular dysfunction, which may cause blood pressure (BP) elevations. We test whether FHD may be associated with higher BP.

Research design and methods

Resting BP, heart rates (in beats per minute: bpm), body composition and fasting concentrations of glucose, insulin, leptin and adiponectin were measured in 332 Japanese women aged 18–24 years. They were grouped according to BP category defined by the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline.

Results

BMI averaged < 22 kg/m2 and did not differ cross-sectionally between 73 with (FHD+) and 259 without FHD (FHD−). FHD+ had higher mean (81 ± 9 vs. 77 ± 7 mmHg, p < 0.001), systolic (111 ± 13 vs. 106 ± 10 mmHg, p = 0.003) and diastolic BP (65 ± 8 vs. 60 ± 7 mmHg, p < 0.001). Prevalence of elevated BP (11.0 vs. 6.2%), hypertension stage 1 (4.1 vs. 0.8%) and stage 2 (2.7 vs. 0.4%) was higher as well (p = 0.01). Endurance training in FHD+ abolished the differences in BP readings and BP prevalence. However, the mean resting heart rate in FHD+ athletes (61.2 bpm) was close to those in FHD+ (64.7 bpm) and FHD− nonathletes (64.6 bpm) and was higher than in FHD− athletes (56.5 bpm). Fat mass and distribution evaluated by dual-energy X-ray absorptiometry, markers of insulin resistance, and serum adipokines studied did not differ between the two groups.

Conclusions

FHD was associated with higher BP and higher prevalence of elevated BP and hypertension, suggesting contribution of microvascular dysfunction in BP elevations in normal weight young Japanese women. FHD may be associated with reduced heart rate response to endurance training as well.
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Metadaten
Titel
Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women
verfasst von
Mari Honda
Ayaka Tsuboi
Satomi Minato-Inokawa
Kaori Kitaoka
Mika Takeuchi
Megumu Yano
Miki Kurata
Bin Wu
Tsutomu Kazumi
Keisuke Fukuo
Publikationsdatum
23.07.2021
Verlag
Springer Singapore
Erschienen in
Diabetology International / Ausgabe 1/2022
Print ISSN: 2190-1678
Elektronische ISSN: 2190-1686
DOI
https://doi.org/10.1007/s13340-021-00525-2

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