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01.12.2017 | Research article | Ausgabe 1/2017 Open Access

BMC Cardiovascular Disorders 1/2017

Association of global and disease-specific health status with outcomes following continuous-flow left ventricular assist device implantation

Zeitschrift:
BMC Cardiovascular Disorders > Ausgabe 1/2017
Autoren:
Kelsey M. Flint, John A. Spertus, Fengming Tang, Philip Jones, Timothy J. Fendler, Larry A. Allen
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12872-017-0510-9) contains supplementary material, which is available to authorized users.

Abstract

Background

The prognostic value of heart failure specific and global health status before and after left ventricular assist device (LVAD) implantation in the usual care setting is not well studied.

Methods

We included 3,836 continuous-flow LVAD patients in the INTERMACS registry. Health status was measured pre-operatively and 3 months post-LVAD using the Kansas City Cardiomyopathy Questionnaire (KCCQ) and EuroQol visual analog scale (VAS). Primary outcomes were mortality/rehospitalization. Inverse propensity weighting was used to minimize bias from missing data.

Results

Pre-operative global and heart failure-specific health status were very poor: KCCQ median 34.6 (IQR 21.4-50.5); VAS median 43 (interquartile range (IQR) 25–65). Health status measures improved 3 months after LVAD placement: KCCQ median 69.3 (IQR 54.2-82.3); VAS median 75 (IQR 60–85). Pre-operative health status was not associated with death (unadjusted HR for lowest vs. highest score quartiles: 1.09 (0.85-1.41) KCCQ; 1.12 (0.85-1.49) VAS) or rehospitalization (unadjusted HR 0.83 (0.72-0.96) KCCQ; 0.99 (0.85-1.16) VAS). Three-month KCCQ was associated with mortality (unadjusted HR 2.17 (1.47-3.21); VAS was not (1.43 (0.94-2.17). Three-month KCCQ added incremental discriminatory value to the HeartMate II Risk Score for death (c-stat 0.60 to 0.66); VAS did not (c-stat 0.59 to 0.60). Three-month health status was associated with rehospitalization (unadjusted HR 1.31 (1.15-1.57) KCCQ; 1.24 (1.05-1.46) VAS), but did not add incremental discriminatory value (c-stat 0.52 to 0.55 and 0.54, respectively).

Conclusions

These real-world data suggest that pre-operative health status has limited association with outcomes after LVAD. However, persistently low health status after surgery may independently signal higher risk for subsequent death. Further study is needed to determine the clinical utility of routinely collected health status data after LVAD implantation.
Zusatzmaterial
Additional file 1: Comparison of baseline characteristics between patients with and without baseline Kansas City Cardiomyopathy Questionnaire (KCCQ) data. Baseline (or pre-operative) characteristics of patients who did and did not have baseline KCCQ data available. (DOCX 92 kb)
12872_2017_510_MOESM1_ESM.docx
Literatur
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