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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Public Health 1/2015

Association of hypoadiponectemia with smokeless/dipping tobacco use in young men

Zeitschrift:
BMC Public Health > Ausgabe 1/2015
Autoren:
Sardar Ahmad, Mohsin Shah, Jawad Ahmed, Aslam Khan, Hamid Hussain, Mary McVey, Asif Ali
Wichtige Hinweise
Sardar Ahmad and Mohsin Shah contributed equally to this work.

Competing interest

The authors declare no competing interest.

Authors’ contributions

SA collected the samples and performed the experimental work. MS conceptualized, participated in preparation and finalization of the manuscript and supervised the study. JA co-supervised the study, helped in the preparation of manuscript. AK helped with proof reading and formatting of manuscript, HH, AA and MM provided assistance in statistical analysis and English editing. All the authors have read and approved the manuscript.

Abstract

Background

Low levels of adiponectin, an adipocytokine with anti-diabetic, antiatherogenic and cardioprotective properties, is associated with increased risk of coronary disease in young men. Previous studies have demonstrated that smokeless tobacco is linked with a reduction of plasma adiponectin levels. However, the influence of smokeless tobacco (dipping tobacco) on plasma adiponectin levels still remains unknown. This study was conducted to assess the plasma adiponectin levels in young men who were using dipping tobacco.

Methods

This was a community based study, which consisted of 186 young lean healthy males aged 20 to 35 years. Among these, 96 men were dipping tobacco users (BMI = 23.07 ± 2.68) and 90 were non-dipping tobacco users (BMI = 23.67 ± 1.46). Serum adiponectin levels were assessed by Enzyme Linked ImmunoSorbent Assay (ELISA).

Results

A statistically significant difference in the mean adiponectin level between tobacco dipper and non-dipper groups was observed (p = 0.0001). A significant difference between the two groups was also observed in baseline parameters including triglyceride and random blood sugar levels (p < 0.05). However, no significant difference was observed between the two groups in other clinical parameters.

Conclusions

Findings of this study suggest that dipping tobacco use was significantly associated with low level of adiponetin in community dwelling young males. This emphasizes the importance of developing community intervention to reduce the use of dipping tobacco, which will reduce the tobacco associated disease burden in the community and will improve public health.
Literatur
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