Cytokines have been found to be the important mediators during renal graft outcome. Therefore, we designed this study to investigate the role of recipients’ IL-1 β promoter (−511) and IL-1 β exon-5 (+3954) polymorphisms with the risk of graft outcome.
We enrolled one hundred recipients of living-related renal transplants together with the age and sex matched controls from the healthy population not having any renal abnormality for this study. Genotype frequencies of the IL-1 β promoter (−511) and IL-1 β exon-5 (+3954) were analyzed using PCR-RFLP technique.
Our results revealed significant differences in the healthy control group and patient group in IL 1β +3954 (p < 0.001). The frequency of variant type TT genotype was higher in RE group as compared to SGF and showed 4 fold risk of rejection (OR = 4.54, p < 0.069) although p value was not significant. The frequency of wild type CC genotype and CT was not significant (p value 0.89 and 0.74 respectively).
Our findings suggest that there is a prevalence of mutated allele of IL-1 gene cluster in our population, which may be responsible for renal dysfunction.
Vamvakopoulos JE, Taylor CJ, Green C, McNeil K, Wallwork J, Goodman R, Metcalfe SM. Interleukin 1 and Chronic Rejection: Possible Genetic Links in Human Heart Allografts: Possible Genetic Links in Human Heart Allografts. Am J Transplant. 2002;2:76–83.
Manchanda PK, Bid HK, Kumar A, Mittal RM. Genetic association of interleukin- 1β and receptor antagonist (IL-Ra) gene polymorphism withallograft function in renal transplant patients. Transpl Immunol. 2006;15(4):289–96. Epub 2006 Feb 24.
Uboldide Capei M, Dametto E, Fasano ME, et al. Cytokines and chronic rejection: a study in kidney transplant long-term survivors. Transplantation. 2004;77:548. CrossRef
Zhao J, Ye Q, Wan Q, Zhou J. Analysis of TNF-β, IL-10, and IL-1 cluster gene polymorphisms and clinical risk factors on acute renal graft rejection. Intern Med. 2013;3:129.
- Association of IL1 beta gene polymorphism and allograft functions in renal transplant recipients :a case control study from Kashmir Valley
Mohammad Ashraf Bhat
Manzoor Ahmad Parry
Aga Syed Sameer
Imtiyaz A. Bhat
Zafar A. Shah
- BioMed Central
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