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European Journal of Pediatrics

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18.05.2020 | Review

Association of initial empirical antibiotic therapy with increased risk of necrotizing enterocolitis

verfasst von: Pradhan Rina, Yan Zeng, Junjie Ying, Yi Qu, Dezhi Mu

Erschienen in: European Journal of Pediatrics | Ausgabe 7/2020

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Abstract

Whether the prophylactic use of antibiotics increase the risk of necrotizing enterocolitis (NEC) remains controversial. This review aims to investigate initial empirical antibiotic therapy (IEAT) and is associated with the risk of NEC. PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched through March 1, 2020. All studies on the impacts of antibiotic exposure on NEC development were included. Thirteen studies including 7901 participants were selected. Two reviewers independently examined the extracted data and assessed the quality of the included studies. Random-effects model was used to pool the effect estimates. We found that IEAT (≥ 5 days) was associated with an increased risk of NEC in adjusted (Odds risk [OR] 1.51, 95% confidence interval [CI] 1.22–1.87) and unadjusted (OR 2.35, 95% CI 1.54–3.57) analyses. Sensitivity analysis also supported these findings.

Conclusion: The evidence suggests an association between IEAT (≥ 5 days) and the risk of NEC. Further studies are needed to address whether the association with IEAT is causal.

What is Known: •Necrotizing enterocolitis (NEC) is acute inflammatory necrosis of the intestinal tractin the newborn infant. •Some observational studies have associated initial empirical antibiotics with an increased risk of subsequent NEC.
What is New: •Initial empirical antibiotic therapy (IEAT) (≥ 5 days) appear to increase the risk of NEC.

Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, Laptook AR, Sanchez PJ, Van Meurs KP, Wyckoff M, Das A, Hale EC, Ball MB, Newman NS, Schibler K, Poindexter BB, Kennedy KA, Cotten CM, Watterberg KL, D’Angio CT, DeMauro SB, Truog WE, Devaskar U, Higgins RD (2015) Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012. JAMA 314:1039–1051CrossRef

Beeby PJ, Jeffery H (1992) Risk factors for necrotising enterocolitis: the influence of gestational age. Arch Dis Child 67:432–435CrossRef

Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, Bauer CR, Donovan EF, Korones SB, Laptook AR, Lemons JA, Oh W, Papile LA, Shankaran S, Stevenson DK, Tyson JE, Poole WK (2007) Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol 196:141–147CrossRef

Cotton CM (2010) Early, prolonged use of postnatal antibiotics increased the risk of necrotising enterocolitis. Arch Dis Child Educ Pract Ed 95:94CrossRef

Abdel GE, Ali AA (2012) Empirical antibiotic treatment and the risk of necrotizing enterocolitis and death in very low birth weight neonates. Ann Saudi Med 32:521–526CrossRef

Rønnestad A, Abrahamsen TG, Medbø S, Reigstad H, Lossius K, Kaaresen PI, Engelund IE, Irgens LM, Markestad T (2005) Septicemia in the first week of life in a Norwegian national cohort of extremely premature infants. Pediatrics 115:e262–e268CrossRef

Ting JY, Synnes A, Roberts A, Deshpandey A, Dow K, Yoon EW, Lee K, Dobson S, Lee SK, Shah PS (2016) Association between antibiotic use and neonatal mortality and morbidities in very low-birth-weight infants without culture-proven sepsis or necrotizing enterocolitis. JAMA Pediatr 170:1181–1187CrossRef

Flannery DD, Ross RK, Mukhopadhyay S, Tribble AC, Puopolo KM, Gerber JS (2018) Temporal trends and center variation in early antibiotic use among premature infants. JAMA Netw Open 1:e180164CrossRef

Egan EA, Nelson RM, Mantilla G, Eitzman DV (1977) Additional experience with routine use of oral kanamycin prophylaxis for necrotizing enterocolitis in infants under 1,500 grams. J Pediatr 90:331–332CrossRef

10.

Siu Y, Ng P, Fung S, Lee C, Wong M, Fok T, So K, Cheung K, Wong W, Cheng A (1998) Double blind, randomised, placebo controlled study of oral vancomycin in prevention of necrotising enterocolitis in preterm, very low birthweight infants. Arch Dis Child-Fetal 79:F105–F109CrossRef

11.

Bonnemaison E, Lanotte P, Cantagrel S, Thionois S, Quentin R, Chamboux C, Laugier J (2003) Comparison of fecal flora following administration of two antibiotic protocols for suspected maternofetal infection. Neonatology 84:304–310CrossRef

12.

Wang Y, Hoenig JD, Malin KJ, Qamar S, Petrof EO, Sun J, Antonopoulos DA, Chang EB, Claud EC (2009) 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis. The ISME journal 3:944–954CrossRef

13.

Moher D (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement Syst.

14.

Walsh MC, Kliegman RM (1986) Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin N Am 33:179–201CrossRef

15.

Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savović J, Schulz KF, Weeks L, Sterne JA (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. Bmj 343:d5928CrossRef

16.

Wells GA, Tugwell P, O Connell D, Welch V, Peterson J, Shea B, Losos M (2015) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses.

17.

Rostom A, Dubé C, Cranney A (2004) Assessments. Appendix D, Quality Assessment Forms

18.

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. Bmj 327:557–560CrossRef

19.

Alexander VN, Northrup V, Bizzarro MJ (2011) Antibiotic exposure in the newborn intensive care unit and the risk of necrotizing enterocolitis. J Pediatr 159:392–397CrossRef

20.

Kuppala VS, Meinzen-Derr J, Morrow AL, Schibler KR (2011) Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. J Pediatr 159:720–725CrossRef

21.

Tagare A, Kadam S, Vaidya U, Pandit A (2010) Routine antibiotic use in preterm neonates: a randomised controlled trial. J Hosp Infect 74:332–336CrossRef

22.

Esmaeilizand R, Shah PS, Seshia M, Yee W, Yoon EW, Dow K (2018) Antibiotic exposure and development of necrotizing enterocolitis in very preterm neonates. Paed Child Healt-Can 23:e56–e61CrossRef

23.

Alsafadi TR, Alotaibi B, Banabilah H, Bukhary E, Garrada S, Alghamdi A, Almohammal M, Alshumrani N, Alqasim M, Abdulkhahar SA (2018) Does prolonged initial empirical antibiotics treatment increase morbidity and mortality in preterm infants<34 weeks? Journal of Clinical Neonatology 7:116CrossRef

24.

Raba AA, O Sullivan A, Semberova J, Martin A, Miletin J (2019) Are antibiotics a risk factor for the development of necrotizing enterocolitis—case-control retrospective study. Eur J Pediatr 178:923–928CrossRef

25.

Afjeh S, Sabzehei M, Seyyed-Ali-Reza Fahimzad FS, Shamshiri A, Esmaili F (2016) Antibiotic therapy for very low birth weigh newborns in NICU. Iran J Pediatr 26

26.

Torres D, Munoz T, Bancalari A, Manriquez C (2018) Prolonged initial empirical antibiotic treatment and the risk of morbidity and mortality in very low birthweight infants. Rev Chil Pediatr 89:600–605PubMed

27.

Al-Mouqdad MM, Aljobair F, Alaklobi FA, Taha MY, Abdelrahim A, Asfour SS (2018) The consequences of prolonged duration of antibiotics in premature infants with suspected sepsis in a large tertiary referral hospital: a retrospective cohort study. Int J Pediatr Adoles Med 5:110–115CrossRef

28.

Fajardo C, Alshaikh B, Harabor A (2019) Prolonged use of antibiotics after birth is associated with increased morbidity in preterm infants with negative cultures. J Matern Fetal Neonatal Med 32:4060–4066CrossRef

29.

Ng P, Dear P, Thomas D (1988) Oral vancomycin in prevention of necrotising enterocolitis. Arch Dis Child 63:1390–1393CrossRef

30.

Yang C, Tang P, Liu P, Huang W, Chen Y, Wang H, Chang J, Lin L (2018) Maternal pregnancy-induced hypertension increases subsequent neonatal necrotizing enterocolitis risk: a nationwide population-based retrospective cohort study in Taiwan. Medicine 97

31.

Bashiri A, Zmora E, Sheiner E, Hershkovitz R, Shoham-Vardi I, Mazor M (2003) Maternal hypertensive disorders are an independent risk factor for the development of necrotizing enterocolitis in very low birth weight infants. Fetal Diagn Ther 18:404–407CrossRef

32.

Manogura AC, Turan O, Kush ML, Berg C, Bhide A, Turan S, Moyano D, Bower S, Nicolaides KH, Galan HL (2008) Predictors of necrotizing enterocolitis in preterm growth-restricted neonates. Am J Obstet Gynecol 198:631–638CrossRef

33.

Halac E, Halac J, Bégué EF, Casañas JM, Indiveri DR, Petit JF, Figueroa MJ, Olmas JM, Rodríguez LA, Obregón RJ (1990) Prenatal and postnatal corticosteroid therapy to prevent neonatal necrotizing enterocolitis: a controlled trial. J Pediatr 117:132–138CrossRef

34.

Roberts D, Brown J, Medley N, Dalziel SR (2017) Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Db Syst Rev

35.

Carter BM, Holditch-Davis D (2008) Risk factors for NEC in preterm infants: how race, gender and health status contribute. Adv Neonatal Care 8:285–290CrossRef

36.

Fouhy F, Guinane CM, Hussey S, Wall R, Ryan CA, Dempsey EM, Murphy B, Ross RP, Fitzgerald GF, Stanton C (2012) High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin. Antimicrob Agents Ch 56:5811–5820CrossRef

37.

Bokulich NA, Chung J, Battaglia T, Henderson N, Jay M, Li H, Lieber AD, Wu F, Perez-Perez GI, Chen Y (2016) Antibiotics, birth mode, and diet shape microbiome maturation during early life. Sci Transl Med 8:343r–382rCrossRef

38.

Dethlefsen L, Huse S, Sogin ML, Relman DA (2008) The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. Plos Biol 6

39.

Yassour M, Vatanen T, Siljander H, Hämäläinen A, Härkönen T, Ryhänen SJ, Franzosa EA, Vlamakis H, Huttenhower C, Gevers D (2016) Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Sci Transl Med 8:343r–381rCrossRef

40.

Gewolb IH, Schwalbe RS, Taciak VL, Harrison TS, Panigrahi P (1999) Stool microflora in extremely low birthweight infants. Arch Dis Child-Fetal 80:F167–F173CrossRef

41.

Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118:229–241CrossRef

42.

Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL (2005) An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122:107–118CrossRef

43.

Caicedo RA, Schanler RJ, Li N, Neu J (2005) The developing intestinal ecosystem: implications for the neonate. Pediatr Res 58:625–628CrossRef

44.

Jilling T, Simon D, Lu J, Meng FJ, Li D, Schy R, Thomson RB, Soliman A, Arditi M, Caplan MS (2006) The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol 177:3273–3282CrossRef

45.

Valpacos M, Arni D, Keir A, Aspirot A, Wilde JC, Beasley S, De Luca D, Pfister RE, Karam O (2018) Diagnosis and management of necrotizing enterocolitis: an international survey of neonatologists and pediatric surgeons. Neonatology 113:170–176CrossRef

Titel: Association of initial empirical antibiotic therapy with increased risk of necrotizing enterocolitis
verfasst von: Pradhan Rina
Yan Zeng
Junjie Ying
Yi Qu
Dezhi Mu
Publikationsdatum: 18.05.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Pediatrics / Ausgabe 7/2020
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-020-03679-4

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