Skip to main content
main-content

01.12.2014 | Original Article | Ausgabe 4/2014

Familial Cancer 4/2014

Association of interleukin-23 receptor gene polymorphisms with risk of bladder cancer in Chinese

Zeitschrift:
Familial Cancer > Ausgabe 4/2014
Autoren:
Tielong Tang, Hui Xue, Shu Cui, Zhiyong Gong, Zhonghai Fei, Shulin Cheng, Chunyan Gui
Wichtige Hinweise
Tielong Tang and Hui Xue have contributed equally to this work.

Abstract

To assess whether polymorphisms of the interleukin-23 receptor (IL23R) gene are associated with bladder transitional cell carcinoma because chronic inflammation contributes to bladder cancer and the IL23R is known to be critically involved in the carcinogenesis of various malignant tumors. 226 patients with bladder cancer and 270 age-matched controls were involved in the study. Polymerase chain reaction–restriction fragment length polymorphism was used for genotyping. Genotype distribution and allelic frequencies between patients and controls were compared. In all three single nucleotide polymorphisms of IL23R studied, the distribution of genotype and allele frequencies of rs10889677 differed significantly between patients and controls. The frequency of allele C of rs10889677 was significantly increased in cases compared with controls (0.2898 vs. 0.1833, odds ratio 1.818, 95 % confidence interval 1.349–2.449). The result indicates that IL23R may play an important role in the susceptibility of bladder cancer in Chinese population.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Weitere Produktempfehlungen anzeigen
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 4/2014

Familial Cancer 4/2014 Zur Ausgabe
  1. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.