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01.01.2012 | General Gynecology

Association of interleukin-6 in women with persistence of DNA-HPV: a nested case–control study

verfasst von: Maria Inês Rosa, Matheus Villas Moraes, Francieli Vuolo, Fabricia Petronilho, Mary Clarisse Bozzetti, Lidia Rosi Medeiros, Cristine Nascente Igansi, Fábio Rosa Silva, Felipe Dal-Pizzol, Daniela Dorneles Rosa

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 1/2012

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Abstract

Objective

To identify the role of Interleukin-6, IL-10 and their epidemiological association in women with persistence of DNA-HPV.

Design and methods

A nested case–control study within a longitudinal cohort study. Cervical specimens and blood samples were collected at enrolment from asymptomatic women who looked for a service of public health in a district of Porto Alegre, Brazil. A logistic regression analysis was performed with 95% confidence intervals. The outcome was the persistence of DNA-HPV infection.

Results

The analysis showed that the age of the first intercourse below 20 years old (OR = 19.65, IC 95% 2.43–68.85), four or more sexual partners during lifetime (OR = 5.67, IC 95% 1.28–24.99), women with a previous altered Pap smear (OR = 10.17, IC 95% 1.80–57.33), marital status (OR = 12.94, IC 95% 2.43–68.85) and IL6 ≤ 3.106 pg/ml were associated with persistence of HPV infection. IL-10 were not associated with the HPV persistence.

Conclusion

The present study suggests that IL-6 levels may be a marker of HPV DNA persistence, although further investigation is necessary.

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Titel: Association of interleukin-6 in women with persistence of DNA-HPV: a nested case–control study
verfasst von: Maria Inês Rosa
Matheus Villas Moraes
Francieli Vuolo
Fabricia Petronilho
Mary Clarisse Bozzetti
Lidia Rosi Medeiros
Cristine Nascente Igansi
Fábio Rosa Silva
Felipe Dal-Pizzol
Daniela Dorneles Rosa
Publikationsdatum: 01.01.2012
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 1/2012
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-1925-7

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Springer Medizin

Association of interleukin-6 in women with persistence of DNA-HPV: a nested case–control study

Abstract

Objective

Design and methods

Results

Conclusion

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Springer Medizin

Abstract

Objective

Design and methods

Results

Conclusion

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