Association of low-frequency oscillations with target selection between the subthalamic nucleus and globus pallidus internus in blepharospasm–oromandibular dystonia
- 01.03.2026
- Original Communication
- Verfasst von
- Guan-Yu Zhu
- Ruo-Yu Ma
- Rui-Li Zhang
- Shou-Yan Wang
- Jian-Guo Zhang
- Lin Shi
- Erschienen in
- Journal of Neurology | Ausgabe 3/2026
Abstract
Background
Stimulation of the subthalamic nucleus (STN) and globus pallidus internus (GPi) is an effective target for treating blepharospasm-oromandibular dystonia, but the individual optimal remains unclear.
Methods
Thirteen patients with blepharospasm-oromandibular dystonia were enrolled. Bilateral STN and GPi electrodes were implanted and externalized, and the signal of the two targets was recorded simultaneously. The power spectrum and burst characteristics were analyzed to see how they were related to symptom severity.
Results
The 1 year follow-up revealed an overall improvement rate of 76.21% ± 12.51%. Those with GPi as final targets showed higher band power and longer average burst duration in the 5.5–12 Hz band in the GPi compared to the STN (P < 0.05). Conversely, those with STN as final targets showed higher band power and longer average burst duration in the 6–10 Hz band in the STN compared to the GPi (P < 0.05). Exclusion of shorter low-frequency bursts led to higher correlation coefficients with BFMDRS-M scores in both the STN and GPi groups (P < 0.01).
Conclusions
Our study suggests that low-frequency oscillatory features may be associated with therapeutic target selection for DBS in blepharospasm–oromandibular dystonia. These findings may help inform target selection strategies and warrant prospective validation for their value in supporting long-term clinical outcomes.
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- Titel
- Association of low-frequency oscillations with target selection between the subthalamic nucleus and globus pallidus internus in blepharospasm–oromandibular dystonia
- Verfasst von
-
Guan-Yu Zhu
Ruo-Yu Ma
Rui-Li Zhang
Shou-Yan Wang
Jian-Guo Zhang
Lin Shi
- Publikationsdatum
- 01.03.2026
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Journal of Neurology / Ausgabe 3/2026
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459 - DOI
- https://doi.org/10.1007/s00415-026-13671-x
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