Background
Methods
Study population
Clinical measurements
Variable | Mean ± SD | n |
---|---|---|
Age (yr) | 59.5 ± 7.7 | |
weight (kg) | 72.0 ± 12.7 | |
BMI | 28.9 ± 5.0 | |
Age at menarche (yr) | 12.8 ± 1.6 | |
Age at menopause (yr) | 48.4 ± 4.5 | |
Parity | 3.4 ± 2.0 | |
Fracture | 55 | |
No fracture | 511 |
Mean ± SD | |||
---|---|---|---|
Variable | Osteoporotic | Osteopenic | Normal |
n = 141 | n = 194 | n = 231 | |
LS BMD (g/cm
2
)
| 0.695 ± 0.065 | 0.827 ± 0.070 | 0.997 ± 0.092 |
RFN BMD (g/cm
2
)
| 0.769 ± 0.103 | 0.843 ± 0.096 | 0.971 ± 0.101 |
LFN BMD (g/cm2)
| 0.775 ± 0.096 | 0.837 ± 0.092 | 0.966 ± 0.113 |
SNP genotyping
Statistical analysis
Results
Polymorphisms | ||||||
---|---|---|---|---|---|---|
Val667Met | Ala1330Val | |||||
GG
|
GA + AA
|
P
|
CC
|
CT + TT
|
P
| |
Parameter
|
n = 498
|
n = 68
|
value
b, e, F
|
n = 452
|
n = 114
|
value
b
|
Osteopenia
c
| 87.5 | 12.5 | 77.6 | 22.4 | ||
+osteoporosis (%)
d
| ||||||
Normals (%)
| 88.7 | 11.3 | 0.373 | 83.1 | 16.9 | 0.066 |
fractured women (%)
| 89.1 | 10.9 | 85.5 | 14.5 | ||
Non fractured women (%)
| 87.9 | 12.1 | 0.499 | 79.3 | 20.7 | 0.182 |
BMD spine (g/cm2)
| 0.869 ± 0.144 | 0.854 ± 0.134 | 0.438 | 0.873 ± 0.145 | 0.841 ± 0.134 | 0.072 |
Tscore spine
| −1.085 ± 1.339 | −1.327 ± 1.305 | 0.170 | −1.044 ± 1.338 | −1.388 ± 1.297 |
0.047*
|
BMD right hip (g/cm2)
| 0.880 ± 0.127 | 0.872 ± 0.136 | 0.62 | 0.882 ± 0.127 | 0.867 ± 0.131 | 0.359 |
Tscore right hip
| −0.451 ± 1.066 | −0.648 ± 1.225 | 0.176 | −0.433 ± 1.060 | −0.639 ± 1.183 | 0.164 |
BMD left hip (g/cm2)
| 0.877 ± 0.129 | 0.870 ± 0.127 | 0.685 | 0.879 ± 0.129 | 0.865 ± 0.127 | 0.448 |
Tscore right hip
| −0.514 ± 1.019 | −0.635 ± 1.131 | 0.380 | −0.499 ± 0.999 | −0.645 ± 1.155 | 0.350 |
BMD total hip
| 0.857 ± 0.120 | 0.851 ± 0.132 | 0.823 | 0.859 ± 0.120 | 0.847 ± 0.126 | 0.430 |
Tscore total hip
| −0.652 ± 1.001 | −0.801 ± 1.182 | 0.522 | −0.635 ± 0.994 | −0.807 ± 1.135 | 0.232 |
Variable
|
B
|
t
|
P value
|
---|---|---|---|
Age (yr)
|
−0.003
|
−3.471
|
0.001*
|
Weight (kg)
|
0.005
|
4.522
|
0.000
|
Age at menarche (yr)
|
−0.005
|
−1.71
|
0.942
|
Age at menopause (yr)
|
−0.002
|
−1.197
|
0.232
|
Parity
|
0.005
|
1.798
|
0.073
|
Fracture
|
−0.026
|
−1.333
|
0.183
|
Ala1330Val genotype
|
0.032
|
1.57
|
0.117
|