The online version of this article (doi:10.1186/1471-230X-14-113) contains supplementary material, which is available to authorized users.
Cheng-Yuan Peng, Ter-Hsin Chen, Yun-Ping Lim contributed equally to this work.
The authors declare no competing interests.
YPL, THC, and CYP designed and carried out the majority of the study. FJT, WLL, and WYL participated in clinical data and information collection. LW conceived and supervised the project and reviewed the manuscript. All authors contributed to and approved the final manuscript by providing constructive suggestions.
The aim of this study was to evaluate whether polymorphisms of the mannose receptor C type 1 (MRC-1) and interleukin 28B (IL-28B) genes are associated with the treatment outcome of patients infected with hepatitis C virus genotypes 1 and 2 (HCV-1 and HCV-2, respectively) who are treated with peginterferon plus ribavirin (PEG-IFNα-RBV).
We analyzed the association of the patients’ sustained viral responses (SVRs) to PEG-IFNα-RBV therapy with 2 single nucleotide polymorphisms (SNPs) in MRC-1 and 3 SNPs in IL-28B. We selected patients infected with either HCV-1 (n = 265) or HCV-2 (n = 195) with or without SVR.
Among the MRC-1 SNPs, rs691005 was found to be associated with SVR in HCV-1-infected patients (P < 0.0001). The IL-28B rs8099917 SNP was found to be associated with SVR in HCV-1- and HCV-2-infected patients (HCV-1, P < 0.0001; HCV-2, P = 0.002), while IL-28B rs955155 and rs10853728 SNPs were found to be associated with SVR in HCV-1-infected patients (P = 0.003) and HCV-2-infected patients (P = 0.02), respectively. We also identified an interaction between MRC-1 rs691005 and IL-28B rs8099917 (P = 0.001). The C-T haplotype was shown to have a positive effect on SVR in HCV-1-infected patients (OR = 1.77, 95% CI = 1.2, 2.62), whereas the T-G haplotype was shown to have a negative effect on SVR in HCV-1-infected patients (OR = 0.28, 95% CI = 0.14, 0.58).
These results suggest that SNPs of IL-28B and MRC-1 can be used as genetic markers for predicting the outcome of PEG-IFNα-RBV treatment of HCV infections.
Additional file 1: Table S1: Five single nucleotide polymorphisms in the MRC1 and IL28B gene identified from 265 HCV-1 and 195 HCV-2 infected PEG-IFNα-RBV therapy patients with or without SVR in Taiwan Chinese population. Table S2. Allele frequencies of MRC1 and IL28B single nucleotide polymorphisms in HCV-1 and HCV-2 infected PEG-IFNα-RBV therapy patients with and without SVR in Taiwan Chinese population. (DOCX 22 KB)
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- Association of MRC-1 and IL-28Bwith the treatment outcome of hepatitis C: a case control study
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