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Neurological Sciences

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06.02.2020 | Review Article

Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis

verfasst von: Feifei Mu, Qian Jiao, Xixun Du, Hong Jiang

Erschienen in: Neurological Sciences | Ausgabe 6/2020

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Abstract

Objective

Orthostatic hypotension (OH) is a common non-motor sign of Parkinson’s disease (PD). Several epidemiological studies have estimated the association between OH and PD with controversial results. Here, a meta-analysis was conducted to evaluate the association between them.

Methods

PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), VIP (Database of Chinese Scientific and Technical Periodicals), and Wanfang databases were searched for eligible publications from October 2003 to December 2017. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. Random effect model was used to calculate the pooled odds ratio (OR) with 95% confidence intervals (CIs) from individual studies. Publication bias was estimated by Egger’s test, Begg’s test, and the funnel plot.

Results

Nineteen studies involving 1620 PD patients and 898 healthy controls were included in this meta-analysis. The pooled estimate of the prevalence of OH in PD was 27.7% compared with 7.9% of that in control. The pooled OR of OH with PD was 4.343 (95% CI 3.323–5.676) with a low heterogeneity (I² = 12.5%, P_{heterogeneity} = 0.301).

Conclusion

In the present meta-analysis, the pooled OR of OH with PD was 4.343 (95% CI 3.323–5.676) with a low heterogeneity, which showed a significant association between OH and increased risk of PD.

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Titel: Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis
verfasst von: Feifei Mu
Qian Jiao
Xixun Du
Hong Jiang
Publikationsdatum: 06.02.2020
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 6/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04277-w

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Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis

Abstract

Objective

Methods

Results

Conclusion

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Update Neurologie

Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

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