Background
Methods
Study design
Inclusion and exclusion criteria
Psychometry
Image acquisition
Tract based spatial statistics (TBSS)
Statistical analysis
Patient characteristics
Effect of treatment by time
Correlation between DCS-effect and DTI white matter integrity
Secondary analysis: Onset age and DCS-effect
Sample preparation and high-performance liquid chromatography (HPLC) with electrochemical detection
Results
Patient characteristics
DCS-first group | PCB-first group | Total | |
---|---|---|---|
N (Male/Female) | 17 (10/7) | 19 (12/7) | 36 (22/14) |
Age (years) | 48.4 ± 16.1 | 40.1 ± 10.7 | 44.0 ± 14.0 |
Age at onset (years) | 22.6 ± 8.5 | 24.3 ± 5.6 | 23.5 ± 7.1 |
Age at starting therapy (years) | 23.9 ± 8.5 | 24.8 ± 5.7 | 24.4 ± 7.1 |
Duration of illness (years) | 25.8 ± 17.3 | 15.8 ± 9.2 | 20.5 ± 14.4 |
Education (years) | 12.4 ± 2.6 | 13.9 ± 2.9 | 13.2 ± 2.9 |
CPZ equivalents (mg/day) | 777.5 ± 614.8 | 871.3 ± 618.0 | 827.0 ± 609.5 |
Psychometrics
Effect of treatment by time
Week within treatment phase | Analysis | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Treatment | Baseline | Week 2 | Week 4 | Week 6 | treatment x time | ||||||
Mean | SD | Mean | SD | Mean | SD | Mean | SD | F |
p
| ||
PANSS | |||||||||||
Positive | DCS | 14.39 | 5.71 | 14.42 | 5.87 | 14.03 | 5.86 | 14.06 | 5.89 | 0.51 | 0.61 |
PCB | 14.72 | 5.79 | 14.19 | 5.46 | 14.11 | 5.16 | 13.97 | 5.62 | |||
Negative | DCS | 20.47 | 7.12 | 20.19 | 6.97 | 20.19 | 6.64 | 19.86 | 7.04 | 0.37 | 0.69 |
PCB | 20.58 | 6.87 | 20.31 | 7.01 | 20.00 | 6.57 | 19.56 | 7.11 | |||
General | DCS | 34.44 | 8.14 | 33.69 | 8.36 | 33.81 | 8.75 | 33.56 | 8.58 | 1.70 | 0.18 |
PCB | 35.22 | 8.11 | 34.56 | 7.78 | 33.97 | 7.26 | 33.83 | 8.48 | |||
SANS | |||||||||||
I | DCS | 13.97 | 8.39 | 13.56 | 8.65 | 13.67 | 8.51 | 13.36 | 8.40 | 0.34 | 0.79 |
PCB | 14.03 | 8.25 | 13.86 | 7.88 | 13.17 | 7.81 | 13.44 | 7.95 | |||
II | DCS | 7.92 | 4.92 | 7.39 | 5.06 | 7.31 | 4.83 | 7.11 | 4.89 | 0.44 | 0.72 |
PCB | 8.22 | 4.67 | 7.75 | 4.78 | 7.19 | 4.71 | 7.22 | 4.75 | |||
III | DCS | 10.14 | 4.26 | 9.89 | 4.45 | 9.78 | 4.32 | 9.61 | 4.32 | 0.50 | 0.62 |
PCB | 10.00 | 3.92 | 9.67 | 4.24 | 9.61 | 4.32 | 9.78 | 4.18 | |||
IV | DCS | 12.44 | 5.34 | 12.22 | 5.53 | 12.08 | 5.26 | 12.08 | 5.44 | 0.18 | 0.84 |
PCB | 12.50 | 5.01 | 12.33 | 5.35 | 12.14 | 5.16 | 12.47 | 5.36 | |||
V | DCS | 5.97 | 3.61 | 5.61 | 3.63 | 5.44 | 3.39 | 4.94 | 3.43 | 0.66 | 0.58 |
PCB | 5.78 | 3.69 | 5.64 | 3.77 | 4.78 | 3.39 | 5.03 | 3.34 | |||
Summary | DCS | 11.75 | 4.72 | 11.33 | 4.76 | 11.14 | 4.59 | 10.78 | 4.74 | 0.79 | 0.44 |
PCB | 11.42 | 4.76 | 11.39 | 4.56 | 10.83 | 4.58 | 10.89 | 4.59 | |||
Total | DCS | 50.44 | 21.88 | 48.67 | 22.57 | 48.28 | 21.69 | 47.11 | 22.55 | 0.52 | 0.62 |
PCB | 50.53 | 20.81 | 49.25 | 20.70 | 46.89 | 20.42 | 47.94 | 20.95 |
Week within treatment phase | Analysis | ||||||
---|---|---|---|---|---|---|---|
Treatment | Baseline | Week 6 | treatment x time | ||||
Mean | SD | Mean | SD | F |
p
| ||
BACS | |||||||
VM | DCS | 34.18 | 15.09 | 37.15 | 16.11 | 0.01 | 0.91 |
PCB | 37.15 | 16.04 | |||||
DS | DCS | 16.48 | 5.76 | 16.97 | 5.96 | 0.20 | 0.65 |
PCB | 17.58 | 5.84 | |||||
TM | DCS | 58.73 | 21.84 | 60.64 | 21.92 | 0.02 | 0.90 |
PCB | 63.33 | 20.69 | |||||
SC | DCS | 46.52 | 16.36 | 47.03 | 15.71 | 0.89 | 0.35 |
PCB | 48.42 | 16.21 | |||||
VFC | DCS | 15.21 | 4.70 | 16.64 | 6.34 | 4.06 | 0.053 |
PCB | 17.24 | 6.44 | |||||
VFL | DCS | 17.55 | 9.58 | 18.12 | 8.23 | 1.06 | 0.31 |
PCB | 18.48 | 8.20 | |||||
TOL | DCS | 14.73 | 5.57 | 15.70 | 5.62 | 0.13 | 0.72 |
PCB | 16.00 | 4.33 | |||||
EQS | |||||||
intra | DCS | 39.29 | 14.40 | 41.04 | 18.23 | 0.08 | 0.78 |
PCB | 38.75 | 15.28 | |||||
inter | DCS | 38.18 | 14.54 | 38.25 | 15.77 | 1.53 | 0.23 |
PCB | 38.75 | 15.28 | |||||
situa | DCS | 30.79 | 16.89 | 33.46 | 18.66 | 0.00 | 0.99 |
PCB | 32.36 | 17.20 |
Differences of DCS-effect by onset age
DCS-effect | SD | F value |
p value | ||
---|---|---|---|---|---|
PANSS | 2.20 | 0.11 | |||
Positive | EOS | 0.83 | 1.83 | 1.54 | 0.22 |
non-EOS | −0.07 | 1.39 | |||
Negative | EOS | 2.17 | 2.79 | 6.17 |
0.02
|
non-EOS | −0.07 | 1.76 | |||
General | EOS | 1.33 | 3.50 | 1.72 | 0.20 |
non-EOS | −0.60 | 3.07 | |||
SANS | 1.11 | 0.38 | |||
I | EOS | 1.50 | 2.74 | 2.02 | 0.16 |
non-EOS | −0.40 | 2.49 | |||
II | EOS | 0.50 | 0.84 | 0.57 | 0.46 |
non-EOS | −0.23 | 1.72 | |||
III | EOS | −0.50 | 1.52 | 0.20 | 0.66 |
non-EOS | −0.10 | 1.60 | |||
IV | EOS | 0.17 | 1.33 | 0.54 | 0.47 |
non-EOS | −0.50 | 1.81 | |||
V | EOS | 0.67 | 1.51 | 0.70 | 0.41 |
non-EOS | −0.23 | 1.76 | |||
Summary | EOS | 0.83 | 1.83 | 1.95 | 0.17 |
non-EOS | −0.30 | 1.51 | |||
Total | EOS | 2.33 | 5.82 | 0.92 | 0.34 |
non-EOS | −1.47 | 7.22 | |||
BACS | 0.85 | 0.56 | |||
VM | EOS | −2.83 | 9.28 | 1.64 | 0.21 |
non-EOS | 0.68 | 5.12 | |||
DS | EOS | −0.17 | 2.32 | 0.19 | 0.66 |
non-EOS | −0.68 | 3.42 | |||
TM | EOS | 0.67 | 5.75 | 0.47 | 0.50 |
non-EOS | −3.96 | 14.86 | |||
SC | EOS | −1.67 | 6.12 | 0.01 | 0.94 |
non-EOS | −1.39 | 7.02 | |||
VFC | EOS | −3.17 | 3.54 | 2.69 | 0.11 |
non-EOS | 0.04 | 3.70 | |||
VFL | EOS | 0.67 | 3.14 | 0.51 | 0.48 |
non-EOS | −0.61 | 5.79 | |||
TOL | EOS | 0.00 | 3.69 | 0.02 | 0.90 |
non-EOS | −0.29 | 3.75 | |||
EQS | 1.18 | 0.34 | |||
intra | EOS | −0.60 | 12.82 | 0.86 | 0.36 |
non-EOS | 2.58 | 6.10 | |||
inter | EOS | −2.40 | 9.21 | 0.65 | 0.43 |
non-EOS | 0.17 | 8.69 | |||
situa | EOS | 3.00 | 6.12 | 0.53 | 0.47 |
non-EOS | 0.79 | 6.06 |
MR diffusion tensor imaging
PANSS | SANS | BACS | EQS | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P | N | G | I | II | III | IV | V | Sumarry | Total | VM | DS | TM | SC | VFC | FVL | TOL | intra | inter | situa | ||
middle cerebellar peduncle | r | −.014 | −.242 | −.023 | .071 | .139 | −.120 | −.061 | −.304 | −.310 | −.104 | .070 | .344 | .281 | .042 | −.243 | −.034 | .012 | .081 | −.414 | −.375 |
p | .952 | .290 | .922 | .759 | .549 | .605 | .793 | .180 | .171 | .654 | .769 | .137 | .230 | .859 | .302 | .888 | .960 | .782 | .141 | .187 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
pontine crossing tract | r | .291 |
−.539
*
| −.140 | −.187 | .173 | .051 | −.373 | −.028 | −.302 | −.134 | −.070 | .365 | .392 | −.080 | .079 | .171 | .180 | .162 | −.107 | −.269 |
p | .201 |
.012
| .545 | .417 | .453 | .827 | .096 | .906 | .184 | .563 | .768 | .114 | .087 | .738 | .740 | .472 | .447 | .581 | .716 | .352 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
genu of corpus callosum | r | .189 | .121 | .303 | −.078 | .148 | .292 | .123 | .095 | .072 | .169 | −.443 | −.076 | .228 | −.095 | −.214 | −.007 |
.585
**
| .066 | .380 | .253 |
p | .412 | .602 | .182 | .735 | .522 | .200 | .596 | .682 | .756 | .464 | .050 | .751 | .334 | .689 | .365 | .977 |
.007
| .822 | .181 | .383 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
body of corpus callosum | r | .386 | −.082 | −.042 | −.013 | .358 | .156 | −.110 | .170 | .087 | .161 | −.102 | .182 | .283 | .140 | −.230 | −.011 |
.460
*
| −.073 | .429 | .108 |
p | .084 | .723 | .858 | .957 | .111 | .499 | .636 | .462 | .708 | .485 | .670 | .442 | .226 | .557 | .329 | .962 |
.041
| .804 | .126 | .714 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
splenium of corpus callosum | r |
−.444
*
| −.432 |
−.574
**
|
−.439
*
| −.115 | .212 | −.404 | −.353 | −.347 | −.378 | .092 | .318 | −.235 | −.015 | .121 | −.136 | −.202 | −.325 | −.182 | −.163 |
p |
.044
| .050 |
.007
|
.047
| .621 | .356 | .069 | .117 | .123 | .091 | .699 | .171 | .318 | .949 | .611 | .568 | .393 | .257 | .534 | .577 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
fornix | r | .334 | .052 | .146 | −.089 | .319 | .180 | −.120 | .082 | .082 | .096 | −.095 | .200 |
.517
*
| −.067 | .017 | −.062 |
.519
*
| .090 | .471 | .412 |
p | .139 | .823 | .529 | .703 | .158 | .435 | .605 | .725 | .725 | .680 | .689 | .397 |
.020
| .780 | .942 | .797 |
.019
| .759 | .089 | .143 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
corticospinal tract R | r | .300 | −.120 | .023 | −.096 | .066 | −.167 | .063 | −.132 | −.141 | −.099 | .304 | .196 | .021 | .197 | .189 |
.530
*
| −.127 | .173 | −.431 | −.038 |
p | .187 | .605 | .923 | .678 | .775 | .468 | .787 | .567 | .543 | .669 | .193 | .408 | .928 | .406 | .425 |
.016
| .593 | .555 | .124 | .898 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
corticospinal tract L | r | .129 | −.023 | −.013 | −.055 | .107 | −.313 | .085 | −.159 | −.084 | −.121 | .435 | .200 | −.045 | .258 | .219 |
.471
*
| −.227 | .161 | −.278 | −.053 |
p | .576 | .920 | .955 | .811 | .645 | .167 | .713 | .492 | .716 | .601 | .056 | .397 | .851 | .272 | .353 |
.036
| .336 | .582 | .335 | .858 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
medial lemniscus R | r | .255 | .193 | −.011 | −.120 | .136 | .193 | .188 | −.114 | −.022 | .064 | .141 | −.082 | .249 | .232 | −.034 | .118 | .342 | −.287 | −.058 | .131 |
p | .265 | .402 | .961 | .605 | .557 | .403 | .414 | .622 | .925 | .782 | .553 | .732 | .289 | .326 | .885 | .621 | .141 | .319 | .844 | .654 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
medial lemniscus L | r | .236 | .023 | −.188 | −.206 | .113 | .066 | .067 | −.154 | −.078 | −.064 | .189 | .094 | .219 | .287 | .031 | .163 | .308 | −.270 | .058 | .104 |
p | .303 | .920 | .415 | .369 | .625 | .777 | .774 | .505 | .736 | .784 | .425 | .693 | .354 | .220 | .896 | .493 | .186 | .350 | .845 | .723 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
inferior cerebellar peduncle R | r | .367 | −.094 | −.181 | .020 | −.065 | .324 | −.040 | −.043 | −.082 | .063 | −.179 | .040 | .187 | −.277 | −.111 | .131 | .397 | −.241 | −.105 | .008 |
p | .102 | .685 | .433 | .932 | .780 | .152 | .863 | .854 | .723 | .787 | .451 | .868 | .430 | .238 | .642 | .583 | .083 | .406 | .721 | .977 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
inferior cerebellar peduncle L | r | .396 | −.133 | −.212 | .025 | .121 | .268 | −.061 | .118 | .017 | .146 | −.105 | .062 | .252 | −.078 | .022 | .268 | .354 | −.146 | .126 | .018 |
p | .076 | .566 | .357 | .915 | .601 | .240 | .791 | .610 | .942 | .528 | .660 | .796 | .284 | .745 | .926 | .254 | .126 | .618 | .667 | .952 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
superior cerebellar peduncle R | r | −.203 | −.091 | −.349 | −.012 | −.234 | −.186 | −.212 | −.233 | −.225 | −.269 | .296 | .217 | .015 | .330 | .083 | .179 | .105 | −.156 | −.071 | −.152 |
p | .376 | .694 | .121 | .959 | .307 | .420 | .357 | .310 | .327 | .238 | .204 | .359 | .949 | .156 | .729 | .449 | .660 | .594 | .808 | .605 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
superior cerebellar peduncle L | r | −.186 | −.229 |
−.484
*
| −.006 | −.361 | −.247 | −.263 | −.313 | −.379 | −.362 | .153 | .245 | .118 | .104 | .084 | .174 | .166 | −.253 | −.153 | −.161 |
p | .419 | .319 |
.026
| .978 | .108 | .280 | .249 | .167 | .090 | .107 | .519 | .298 | .620 | .662 | .726 | .462 | .483 | .384 | .601 | .582 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
cereberal peduncle R | r | .075 | −.164 | −.245 | .125 | −.055 | .028 | −.221 | −.085 | −.169 | −.057 | −.089 | .178 |
.465
*
| .196 | .082 | −.050 | .049 | .023 | .043 | .479 |
p | .748 | .477 | .285 | .590 | .812 | .905 | .336 | .716 | .465 | .807 | .708 | .452 |
.039
| .406 | .731 | .833 | .838 | .938 | .885 | .083 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
cereberal peduncle L | r | −.307 | −.053 | −.179 | −.003 | −.180 | .260 | −.189 | −.145 | −.131 | −.077 | −.358 | .074 | −.013 | −.048 | −.016 | −.129 | .324 | −.022 | .147 | .257 |
p | .175 | .818 | .438 | .989 | .435 | .255 | .413 | .532 | .572 | .741 | .121 | .758 | .956 | .842 | .946 | .587 | .164 | .941 | .617 | .375 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
anterior limb of internal capsule R | r | .189 | .220 | .315 | .101 | .054 | .353 | .202 | .028 | .157 | .231 | .015 | −.225 | .295 | .325 | .371 | −.163 | .223 | −.275 | .085 | .354 |
p | .412 | .339 | .165 | .663 | .815 | .116 | .380 | .903 | .497 | .314 | .950 | .341 | .207 | .162 | .107 | .493 | .344 | .342 | .772 | .214 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
anterior limb of internal capsule L | r | .033 | .086 | .262 | −.136 | −.143 | .310 | .151 | .002 | −.057 | .055 | −.425 | −.239 | .083 | .050 | .014 | −.195 |
.463
*
| −.118 | .070 | .216 |
p | .886 | .710 | .252 | .558 | .537 | .171 | .514 | .993 | .807 | .813 | .062 | .311 | .728 | .834 | .952 | .411 |
.040
| .689 | .813 | .459 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
posterior limb of internal capsule R | r | −.413 | −.326 | −.369 | −.323 | −.113 | .144 | −.402 | −.395 | −.303 | −.370 | −.018 | .198 | −.003 | .258 | .356 | −.218 | −.422 | .015 | −.087 | .287 |
p | .063 | .149 | .100 | .154 | .624 | .533 | .071 | .076 | .181 | .099 | .940 | .403 | .989 | .272 | .123 | .356 | .064 | .960 | .767 | .320 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
posterior limb of internal capsule L | r | −.383 | −.363 | −.251 | −.288 | −.180 | .153 | −.177 | −.394 | −.239 | −.302 | .083 | .235 |
−.477
*
| .112 | .193 | −.098 | −.433 | −.223 | −.216 | −.141 |
p | .087 | .106 | .272 | .205 | .436 | .507 | .444 | .077 | .297 | .183 | .728 | .318 |
.033
| .639 | .416 | .682 | .057 | .444 | .459 | .630 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
retrolenticular part of internal capsule R | r |
−.465
*
| .224 | −.008 | −.293 | −.353 | −.118 | .064 | −.377 | −.270 | −.352 | −.153 | −.380 | −.105 | .255 | −.033 | −.307 | −.256 | .079 | −.118 |
.604
*
|
p |
.034
| .330 | .972 | .197 | .116 | .609 | .783 | .092 | .236 | .118 | .519 | .098 | .660 | .277 | .889 | .188 | .277 | .789 | .687 |
.022
| |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
retrolenticular part of internal capsule L | r | −.249 | −.021 | .030 | −.017 | .052 | .167 | .044 | −.202 | −.090 | −.002 | −.057 | −.056 | −.072 | .270 | −.039 | .105 | −.319 | .418 | −.095 | .329 |
p | .276 | .927 | .898 | .942 | .824 | .469 | .850 | .380 | .698 | .993 | .811 | .816 | .763 | .249 | .871 | .659 | .171 | .137 | .746 | .251 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
anterior corona radiata R | r | .246 | .285 |
.440
*
| −.248 | .045 | .213 | .386 | −.088 | −.036 | .070 | .082 | −.189 | .170 | −.058 | .114 | −.181 | .353 | −.256 | −.156 | .218 |
p | .282 | .210 |
.046
| .279 | .846 | .354 | .084 | .704 | .876 | .764 | .731 | .424 | .474 | .807 | .631 | .444 | .126 | .378 | .594 | .454 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
anterior corona radiata L | r | .052 | .081 | .197 | −.421 | .152 | .257 | .204 | −.120 | −.079 | −.021 | −.003 | −.012 | .186 | −.207 | .157 | −.176 | .129 | −.117 | −.045 | .286 |
p | .824 | .727 | .391 | .057 | .510 | .260 | .375 | .605 | .734 | .928 | .991 | .959 | .432 | .381 | .508 | .457 | .586 | .690 | .879 | .322 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
superior corona radiata R | r | −.272 | .141 | −.059 | .148 | .045 | .364 | .053 | −.049 | .144 | .176 | .112 | −.141 | −.264 | .243 | .051 | −.290 | .042 | −.385 | −.044 | −.075 |
p | .233 | .541 | .798 | .522 | .846 | .105 | .820 | .832 | .532 | .445 | .640 | .554 | .262 | .302 | .831 | .215 | .861 | .174 | .880 | .799 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
superior corona radiata L | r | −.100 | .196 | .007 | −.026 | .102 | .398 | .295 | .055 | .290 | .247 | .181 | −.170 | −.401 | .316 | −.027 | −.066 | −.021 |
−.614
*
| −.011 | −.133 |
p | .668 | .395 | .974 | .910 | .661 | .074 | .194 | .812 | .202 | .280 | .445 | .473 | .080 | .175 | .912 | .782 | .932 |
.019
| .971 | .650 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
posterior corona radiata R | r | −.374 | −.058 | −.111 | −.073 | .178 | .169 | .067 | −.137 | .054 | .040 | −.241 | −.186 | −.292 | .110 | −.166 | −.244 |
−.529
*
| −.120 | −.195 | −.036 |
p | .095 | .804 | .633 | .754 | .439 | .463 | .772 | .552 | .816 | .862 | .306 | .433 | .211 | .645 | .485 | .300 |
.017
| .683 | .505 | .904 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 |
20
| 14 | 14 | 14 | |
posterior corona radiata L | r | −.154 | .013 | .021 | −.006 | .136 | .178 | .346 | −.043 | .174 | .176 | −.198 | −.228 | −.357 | .043 | −.190 | −.099 | −.312 |
−.549
*
| −.274 | −.481 |
p | .505 | .955 | .927 | .980 | .557 | .440 | .125 | .853 | .451 | .445 | .402 | .333 | .123 | .858 | .422 | .678 | .180 |
.042
| .343 | .082 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
posterior thalamic radiation R | r | .238 | .026 | .223 | −.341 | .079 | −.013 | .198 | −.265 | −.259 | −.147 | .019 | .010 | .268 | .137 | −.202 | −.118 | −.135 | .150 | −.315 |
.553
*
|
p | .298 | .910 | .331 | .130 | .733 | .955 | .389 | .245 | .257 | .525 | .936 | .965 | .253 | .565 | .393 | .619 | .570 | .609 | .272 |
.040
| |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
posterior thalamic radiation L | r | .183 |
.443
*
|
.571
**
| −.010 | −.005 | .147 |
.598
**
| −.008 | .111 | .219 | −.195 | −.389 | .016 | .107 | −.352 | −.113 | .275 | .039 | −.094 | .353 |
p | .427 |
.044
|
.007
| .965 | .983 | .526 |
.004
| .972 | .633 | .340 | .409 | .090 | .946 | .653 | .128 | .634 | .241 | .895 | .748 | .216 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
sagittal stratum R | r | .190 | −.045 | .224 | −.240 | .262 | −.029 | .186 | −.014 | −.106 | .019 | −.025 | .085 |
.521
*
| .254 | .010 | .030 | −.048 | .369 | .131 |
.615
*
|
p | .410 | .848 | .328 | .295 | .251 | .899 | .419 | .953 | .647 | .934 | .916 | .721 |
.019
| .280 | .967 | .900 | .840 | .194 | .656 |
.019
| |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
sagittal stratum L | r | .191 | .080 | .170 | −.301 | .318 | −.118 | .224 | −.015 | −.078 | −.005 | .064 | .178 |
.596
**
| .061 | −.088 | −.140 | .285 | .110 | .231 | .355 |
p | .406 | .731 | .462 | .185 | .160 | .610 | .329 | .947 | .736 | .981 | .789 | .453 |
.006
| .799 | .713 | .555 | .224 | .708 | .428 | .212 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
external capsule R | r | .300 | .167 | .059 | −.027 | .172 | −.030 | .076 | .097 | −.112 | .082 | −.032 | −.182 |
.515
*
| .253 | −.217 | −.049 |
.559
*
| −.019 | .179 | .461 |
p | .186 | .469 | .800 | .908 | .455 | .896 | .743 | .677 | .629 | .723 | .894 | .442 |
.020
| .283 | .357 | .836 |
.010
| .949 | .541 | .097 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
external capsule L | r | .179 | .166 | .083 | .095 | .172 | .023 | .041 | .229 | −.020 | .181 | −.235 | −.184 | .386 | .002 | −.205 | −.180 |
.702
**
| −.051 | .291 | .228 |
p | .437 | .471 | .721 | .681 | .456 | .923 | .860 | .319 | .932 | .432 | .319 | .437 | .092 | .994 | .386 | .448 |
.001
| .862 | .313 | .432 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
cingulum (cingulate gyrus) R | r |
.455
*
| .164 | .080 | .116 | −.028 | −.032 | .227 | .195 | −.023 | .166 | −.098 | −.029 |
.584
**
| .078 | −.111 | .169 |
.869
**
| −.041 | .211 | .221 |
p |
.038
| .477 | .732 | .618 | .904 | .891 | .322 | .396 | .922 | .472 | .680 | .903 |
.007
| .743 | .641 | .476 |
.000
| .890 | .470 | .448 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
cingulum (cingulate gyrus) L | r |
.481
*
| .126 | .307 | .169 | −.098 | −.037 | .323 | .099 | −.148 | .161 | −.259 | −.216 |
.575
**
| .003 | −.159 | −.159 |
.664
**
| −.152 | −.126 | .185 |
p |
.027
| .587 | .176 | .463 | .672 | .873 | .153 | .669 | .523 | .486 | .270 | .361 |
.008
| .989 | .503 | .503 |
.001
| .605 | .669 | .527 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 |
20
| 14 | 14 | 14 | |
cingulum (hippocampus) R | r | .196 | .095 | .036 | −.029 | −.202 | −.203 | .041 | −.204 | −.268 | −.185 | −.166 | −.087 |
.543
*
| .084 | .048 | −.084 | .370 | −.068 | −.001 | .382 |
p | .395 | .682 | .878 | .900 | .380 | .378 | .862 | .376 | .240 | .422 | .483 | .715 |
.013
| .724 | .839 | .724 | .109 | .816 | .998 | .178 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
cingulum (hippocampus) L | r | .187 | −.183 | −.229 | .141 | −.064 | −.220 | −.104 | −.050 | −.130 | −.080 | −.150 | .100 | .291 | .141 | .061 | .046 | .403 | −.215 | .170 | −.035 |
p | .417 | .426 | .318 | .541 | .784 | .339 | .655 | .830 | .574 | .730 | .527 | .676 | .214 | .553 | .797 | .848 | .078 | .461 | .562 | .905 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
fornix stria terminalis R | r |
.451
*
| −.032 | .097 | .031 | −.061 | −.043 | −.115 | .070 | −.252 | −.027 | −.059 | −.056 |
.668
**
| .014 | .088 | .013 | .357 | .219 | −.132 |
.561
*
|
p |
.040
| .892 | .675 | .893 | .794 | .852 | .618 | .763 | .271 | .909 | .805 | .813 |
.001
| .955 | .711 | .956 | .122 | .451 | .654 |
.037
| |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
fornix stria terminalis L | r | .267 | .103 | .084 | .104 | .127 | .371 | −.198 | .159 | −.006 | .182 | −.312 | −.136 |
.472
*
| −.147 | −.119 | −.138 |
.581
**
| .206 | .171 | .429 |
p | .243 | .656 | .716 | .652 | .583 | .098 | .391 | .491 | .980 | .430 | .180 | .569 |
.036
| .537 | .618 | .563 |
.007
| .481 | .559 | .126 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
superior longitudinal fasciculus R | r | −.025 | .033 | −.121 | −.270 | .052 | .310 | −.173 | −.117 | −.151 | −.087 | −.061 | .074 | .361 | .200 | .105 | .201 |
.483
*
| .061 | .116 | .420 |
p | .913 | .888 | .603 | .237 | .821 | .172 | .453 | .614 | .514 | .707 | .798 | .757 | .118 | .397 | .658 | .396 |
.031
| .835 | .692 | .135 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
superior longitudinal fasciculus L | r | −.262 | .218 | −.103 | −.147 | .228 | .260 | .123 | −.033 | .233 | .107 | .099 | −.007 | .020 | .311 | .025 | .295 | .091 | .132 | .412 | .287 |
p | .252 | .343 | .658 | .524 | .320 | .256 | .595 | .887 | .310 | .643 | .679 | .978 | .933 | .183 | .917 | .207 | .703 | .652 | .143 | .320 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
superior front occipital fasciculus R | r | −.260 | .213 | .212 | .003 | −.117 | .328 | .135 | −.163 | −.016 | .054 | −.136 | −.261 | −.095 | .126 | −.144 | −.435 | −.036 | −.248 | −.156 | .370 |
p | .255 | .354 | .357 | .991 | .613 | .147 | .559 | .479 | .945 | .817 | .567 | .266 | .689 | .596 | .546 | .056 | .881 | .392 | .595 | .192 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
superior front occipital fasciculus L | r |
−.484
*
| −.185 | −.129 | −.116 | −.135 | .398 | −.085 | −.114 | −.009 | −.023 | −.220 | −.040 | −.397 | .145 | .188 | −.051 |
−.494
*
| .050 | −.053 | .196 |
p |
.026
| .422 | .577 | .617 | .558 | .074 | .715 | .622 | .970 | .922 | .350 | .868 | .083 | .541 | .428 | .831 |
.027
| .866 | .858 | .503 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
uncinate fasciculus R | r | .286 | .159 | .047 | .004 | .133 | −.072 | −.054 | −.038 | −.044 | −.017 | .122 | .020 |
.489
*
| .366 | −.045 | .104 |
.485
*
| .064 | .372 | .496 |
p | .210 | .490 | .838 | .987 | .565 | .756 | .818 | .871 | .848 | .941 | .608 | .934 |
.029
| .113 | .849 | .662 |
.030
| .827 | .191 | .071 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
uncinate fasciculus L | r | .187 | .271 | .170 | .167 | .096 | .027 | .157 | .153 | .048 | .198 | .045 | −.263 | .219 | .223 | −.136 | −.049 |
.484
*
| −.032 | .291 | .298 |
p | .416 | .234 | .462 | .470 | .678 | .908 | .496 | .508 | .836 | .390 | .850 | .263 | .355 | .344 | .568 | .837 |
.031
| .913 | .313 | .300 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
tapetum R | r | .128 | −.075 | −.095 | −.280 | .302 | .288 | −.088 | −.211 | −.117 | −.043 | .046 | .021 | .185 | .161 | −.196 | −.144 | −.155 | −.066 | −.242 | .176 |
p | .580 | .745 | .683 | .219 | .183 | .206 | .705 | .359 | .612 | .853 | .848 | .930 | .436 | .498 | .408 | .545 | .514 | .822 | .404 | .548 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 | |
tapetum L | r | .077 | .106 | .021 | .151 | .054 | .426 | .018 | −.023 | .029 | .197 | .107 | −.172 | −.100 | −.130 | −.339 | −.367 | .117 | −.495 | −.294 | −.259 |
p | .740 | .648 | .928 | .515 | .817 | .054 | .940 | .920 | .902 | .392 | .652 | .468 | .674 | .584 | .144 | .111 | .624 | .072 | .307 | .370 | |
n | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 14 | 14 | 14 |