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31.08.2019 | Sleep Breathing Physiology and Disorders • Original Article

Association of serum adiponectin level with cystatin C in male patients with obstructive sleep apnea syndrome

verfasst von: Dong-Dong Chen, Jie-Feng Huang, Song-Ping Huang, Xiao-Fang Chen

Erschienen in: Sleep and Breathing | Ausgabe 3/2020

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Abstract

Purpose

Obstructive sleep apnea syndrome (OSAS) was suggested to exert an effect on renal function. However, the specific mechanism was still unknown. We try to find the association among OSAS, adiponectin, and cystatin C and the effect of adiponectin on renal function in OSAS patients.

Methods

Seventeen healthy men and seventy-three men which only had OSAS were included in the end. Apnea-hypopnea index (AHI), oxygen desaturation index (ODI), the percentage of total sleep time spent with SpO₂ < 90% (T90%), lowest O₂ saturation (LaSO₂), Epworth Sleepiness Scale (ESS) score, serum adiponectin, and high-sensitive C-reactive protein (hsCRP) were detected in all subjects, and renal function was evaluated with creatinine, cystatin C, and estimated glomerular filtration rate (eGFR).

Results

Demographic data, creatinine, and eGFR did not differ among the studied groups. Decreased serum adiponectin levels were associated with severe OSAS. OSAS patients had a higher hsCRP and cystatin C than those without OSAS. Serum adiponectin levels had a negative association with cystatin C. After adjusted for confounders, adiponectin, hsCRP, and ODI had a significant prediction on the cystatin C (β = − 0.218, p = 0.011; β = 0.226, p = 0.037; and β = 0.231, p = 0.029).

Conclusions

Decreased serum adiponectin was associated with increased cystatin C in male OSAS patients. These results suggest that serum adiponectin might be a regulatory factor for renal function in OSAS.

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Titel: Association of serum adiponectin level with cystatin C in male patients with obstructive sleep apnea syndrome
verfasst von: Dong-Dong Chen
Jie-Feng Huang
Song-Ping Huang
Xiao-Fang Chen
Publikationsdatum: 31.08.2019
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 3/2020
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-019-01927-y

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Association of serum adiponectin level with cystatin C in male patients with obstructive sleep apnea syndrome

Abstract

Purpose

Methods

Results

Conclusions

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Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Purpose

Methods

Results

Conclusions

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