Increased serum complement C3 has been related to body fat mass, metabolic syndrome and chronic diseases. The purpose of this study was to evaluate the levels of C3 in the subjects of normal weight obese (hereafter NWO) as well as their possible relationships with metabolic syndrome and inflammation.
In this case-control study, 40 obese women with normal weight (body mass index (BMI) = 18.5–24.9 kg/m2) and body fat percentage above 30% (fat mass (FM) > 30%) and 30 non-obese women (BMI = 18.5–24.9 kg/m2) and fat percentage less than 25% (FM < 25%) were selected as the study sample. Body composition was analyzed using Bio Impedance analyzer. Blood samples were then collected and analyzed for fasting serum concentration of lipid components of metabolic syndrome, insulin, serum complement C3 and High sensitivity C reactive protein (hsCRP).
Mean waist and hip circumferences in NWO was higher than non-NWO (74.78 ± 4.81 versus 70.76 ± 2.91 and 99.12 ± 4.32 versus 93.16 ± 2/91, respectively, P-value < 0.001). However, the mean waist-to-hip ratio did not differ significantly (p = 0.448). The mean fasting serum concentration of complement C3, hsCRP and insulin was higher in NWO compared to that in non-NWO (P-value < 0.05). Moreover, insulin sensitivity in NWO was lower than that in non-NWO (0.357 versus 0.374, p-value = 0.043). Moreover, a significant correlation was found between body fat percentage and fasting serum complement C3 and insulin concentration (r = 0.417 and r = 0.254, p-value < 0.005, respectively).
Obese women with normal body mass index but high body fat percentage have higher serum C3 and are at a higher risk for metabolic dysregulation and metabolic syndrome than the healthy non-obese subjects.
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults.NCD Risk Factor Collaboration (NCD-RisC). Lancet. 2017. doi: 10.1016/S0140-6736(17)32129-3.
Safiri S, Kelishadi R, Qorbani M, Lotfi R, Djalalinia S, Salehifar D, et al. Association of dietary behaviors with physical activity in a nationally representative sample of children and adolescents: the CASPIAN- IV study. Int J Pediatr. 2016;4(3):1505–17.
Khashayar P, Heshmat R, Qorbani M, Motlagh ME, Aminaee T, Ardalan G et al. Metabolic Syndrome and Cardiovascular Risk Factors in a National Sample of Adolescent Population in the Middle East and North Africa: The CASPIAN III Study. Int J Endocrinol. 2013;702095. doi: 10.1155/2013/702095. Epub 2013 Feb 7.
Azizi-Soleiman F, Motlagh ME, Qorbani M, Heshmat R, Ardalan G, Mansourian M, et al. Dietary habits and health related behaviors in Iranian children and adolescents: the CASPIAN- IV study. Int J Pediatr. 2016;4(7):2087–97.
Mehrkash M, Kelishadi R, Mohammadian S, Mousavinasab F, Qorbani M, Hashemi ME, et al. Obesity and metabolic syndrome among a representative sample of Iranian adolescents. Southeast Asian J Trop Med Public Health. 2012;43(3):756–63. PubMed
WHO. Obesity. Preventing and managing the global epidemic. Report on a WHO Consultation of Obesity, 3e5 June 1997. Geneva: WHO; 1998. WHO/NUT/NCD/98.1
De Lorenzo A, Del Gobbo V, Premrov MG, Bigioni M, Galvano F, Di Renzo L. Normal-weight obese syndrome: early inflammation? Am J ClinNutr. 2007;85(1):40–5.
Romero-Corral A, Somers VK, Sierra-Johnson J, et al. Accuracy of body mass index in diagnosing obesity in the adult general population. Int J Obes. 2008;32:959–66. CrossRef
Oliveros E, Virend K. Somers, Sochor O. The Concept of Normal Weight Obesity. Prog Cardio vasc Dis. 2014;56(4)426–433.
Onat A, Uzunlar B, Hergenç G, Yazici M, Sari I, Uyarel H, et al. Cross-sectional study of complement C3 as a coronary risk factor among men and women. ClinSci (Lond). 2005;108(2):129–3. CrossRef
Halkes CJM, van Dijk H, de Jaegere PPT, et al. Postprandial increase of complement component 3 in normolipidemic patients with coronary artery disease: effects of expandeddose simvastatin. ArteriosclerThrombVasc Biol. 2001;21:1526–30. CrossRef
Muscari A, Antonelli S, Bianchi G, Cavrini G, Dapporto S, Ligabue A, et al. Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an elderly population. Diabetes Care. 2007;30(9):2362–8. CrossRefPubMed
vanOostrom AJ, Alipour A, Plokker TW, Sniderman AD, Cabezas MC. The metabolic syndrome in relation to complement component 3 and postprandial lipemia in patients from an outpatient lipid clinic and healthy volunteers. Atherosclerosis. 2007;190(1):167–73. CrossRef
Puchau B, Zulet MA, et al. Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults. Eur J ClinNutr. 2009;63(7):858–64. CrossRef
vanGreevenbroek MM, Jacobs M, van der Kallen CJ, et al. The cross sectional association between insulin resistance and circulating complement C3 is partly explained by plasma alanine aminotransferase, independent of central obesity and general inflammation (the CODAM study). Eur J ClinInvest. 2011;41:372–9. CrossRef
Conus F, Rabasa-Lhoret R, Péronnet F. Metabolic and BehavioralCharacteristics of metabolically obese normal-weight (MONW) subjects. Appl Physiol Nutr Metab. 2004;32(1):4–12. CrossRef
Bjorntrop P. Abdominal obesity and the metabolic syndrome. Ann Med. 1992;24:465–8. CrossRef
Ahrén B, Havel PJ, Pacini G, Cianflone K. Acylation stimulating protein stimulates insulin secretion. Int J Obes. 2003;27:1037–43. CrossRef
Poursafa P, Kelishadi R, Ghasemian A, et al. Trends in health burden of ambient particulate matter pollution in Iran, 1990–2010: findings from the global burden of disease study 2010. Environ Sci Pollut Res. 2015;22:18645–53. CrossRef
- Association of serum complement C3 with metabolic syndrome components in normal weight obese women
Mohamad Reza Mohajeri-Tehrani
- BioMed Central
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