Background
Methods
Study population
Data collection
Definition of anthropomorphic indices of obesity
Definition of metabolic syndrome
Statistical analysis
Ethical considerations
Results
Clinical and metabolic characteristics of the study population
Men (n = 167) | Women (n = 309) |
p value | |
---|---|---|---|
Age | 55 ± 23 | 50 ± 20 | <0.0001 |
Weight (kg) | 71.00 ± 23.00 | 70.00 ± 25.00 | 0.984 |
Height (m) | 1.70 ± 0.20 | 1.60 ± 0.10 | <0.0001 |
BMI (kg/m2) | 25.30 ± 6.30 | 28.00 ± 6.60 | <0.0001 |
WC (cm) | 91.04 ± 12.6 | 93.58 ± 14.0 | 0.091 |
WHR (cm) | 0.91 ± 0.09 | 0.87 ± 0.09 | <0.0001 |
BF (%) | 22.90 ± 8.62 | 34.00 ± 10.42 | <0.0001 |
SBP (mm Hg) | 137 ± 37 |
128 ± 33
| <0.0001 |
DBP (mm Hg) | 86 ± 21 | 82 ± 20 | 0.006 |
Blood glucose (mmol/L) [mg/dL] | 5.0 ± 1.10 [90.9 ± 20] | 4.80 ± 1.15 [87.3 ± 20.9] | 0.204 |
Total cholesterol (mmol/L) [mg/dL] | 4.14 ± 1.07 [165.6 ± 42.8] | 4.45 ± 1.16 [178 ± 46.4] | 0.05 |
Triglycerides (mmol/L) [mg/dL] | 1.20 ± 0.45 [109.9 ± 40.9] | 1.26 ± 0.35 [114.5 ± 31.8] | 0.024 |
LDL-c (mmol/L) [mg/dL] | 1.48 ± 0.97 [59.2 ± 38.8] | 1.78 ± 1.17 [71.2 ± 46.8] | 0.031 |
HDL-c (mmol/L) [mg/dL] | 2.13 ± 0.99 [85.2 ± 39.6] | 2.14 ± 0.91 [85.6 ± 36.4] | 0.763 |
Insulin (µU/mL) | 2.14 ± 2.16 | 2.73 ± 2.47 | 0.020 |
HOMA-IR | 8.64 ± 0.25 | 11.05 ± 11.13 | 0.031 |
Adiponectin (µg/mL) | 7.65 ± 5.55 | 10.75 ± 8.90 | 0.038 |
Leptin (ng/mL) | 4.80 ± 6.20 | 18.50 ± 24.40 | <0.0001 |
Correlations between leptin-to-adiponectin ratio and anthropometric indexes of obesity, blood pressure, blood lipids and insulin resistance
Adiponectin | Leptin | LAR | ||||
---|---|---|---|---|---|---|
R |
p
| R |
P
| r |
p
| |
IMC (kg/m2) | −0.297* | 0.000 | 0.649* | 0.000 | 0.669* | 0.000 |
WC (cm) | −0.297* | 0.000 | 0.560* | 0.000 | 0.595* | 0.000 |
SBP (mm Hg) | 0.013 | 0.820 | 0.045 | 0.416 | 0.034 | 0. 537 |
DBP (mm Hg) | −0.005 | 0.921 | 0.116* | 0.036 | 0.099 | 0.073 |
Blood glucose (mmol/L) | −0.042 | 0.443 | −0.014 | 0.797 | 0.013 | 0.814 |
TG (mmol/L) | −0.140* | 0.011 | 0.150* | 0.007 | 0.190* | 0.001 |
HDL-c (mmol/L) | 0.095 | 0.087 | −0.012 | 0.833 | −0.058 | 0.296 |
Insulin (µU/mL) | −0.123 | 0.059 | 0.332* | 0.000 | 0.333* | 0.000 |
HOMA-IR | −0.139* | 0.032 | 0.288* | 0.000 | 0.306* | 0.000 |
Association between leptin-to-adiponectin ratio and metabolic syndrome
Variables | Metabolic syndrome | |||
---|---|---|---|---|
Unadjusted OR (CI) |
p
| Adjusted OR (CI) |
p
| |
Leptin | 1.429 (1.134–1.802) | 0.003 | 1.469 (1.16–1.86) | 0.001 |
Adiponectin | 0.468 (0.304–0.720) | 0.001 | 0.359 (0.225–0.573) | 0.000 |
LAR | 1.502 (1.231–1.833) | 0.000 | 1.573 (1.281–1.932) | 0.000 |