Background
Methods
Subjects
Genetic analyses
Statistical analyses
Results
Genetic structure data
rsSNPs | Genotypes, n(%) | P-value for HWE test | ||
---|---|---|---|---|
rs877087 | TT | CT | CC | 0.102 |
1279(94.2) | 76(5.6) | 3(0.2) | ||
rs2132207 | GG | AG | AA | 0.443 |
463(34.2) | 668(49.4) | 221(16.4) | ||
rs658750 | GG | AG | AA | 0.629 |
978(72.2) | 349(25.8) | 28(2.0) | ||
rs2229116 | AA | AG | GG | 0.191 |
923(66.4) | 411(29.5) | 57(4.1) | ||
Haplotypes
|
Estimated frequencies and number of samples
a
| |||
TGGA | 0.504, n = 681 | |||
TAGA | 0.158, n = 214 | |||
TAAA | 0.121, n = 164 | |||
TAGG | 0.102, n = 138 | |||
TGGG | 0.057, n = 77 |
Relationship between RYR3 polymorphisms and atherosclerosis severity
Arteries | Ath (+/−) | rs877087 genotypes, n(%) | rs2229116 genotypes, n(%) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TT | CT | CC | TT vs. CT + CC | AA | AG | GG | AA vs. AG + GG | ||||||
p
a
| OR(95% CI)b
|
p
b
|
p
a
| OR(95% CI)b
|
p
b
| ||||||||
PAI | + | 319(96.4%) | 11(3.3%) | 1(0.3%) |
0.023
| 2.07 |
0.038
| 241(71.5%) | 84(24.9%) | 12(3.6%) |
0.008
| 1.38 |
0.035
|
(Total) | - | 840(93.2%) | 59(6.6%) | 2(0.2%) | (1.04–4.12) | 593(64.1%) | 292(31.6%) | 40(4.3%) | (1.02–1.86) | ||||
Common carotid | + | 666(94.7%) | 35(5.0%) | 2(0.3%) | 0.214 | 1.31 | 0.294 | 501(69.9%) | 190(26.5%) | 26(3.6%) |
0.003
| 1.45 |
0.003
|
- | 597(93.5%) | 40(6.3%) | 1(0.2%) | (0.79–2.15) | 412(62.7%) | 214(32.6%) | 31(4.7%) | (1.13–1.86) | |||||
(Total) | |||||||||||||
PAI | + | 183(96.3%) | 7(3.7%) | 0(0%) | 0.061 | 1.87 | 0.164 | 140(71.8%) | 47(24.1%) | 8(4.1%) |
0.042
| 1.58 |
0.026
|
(Male) | - | 440(92.8%) | 33(7.0%) | 1(0.2%) | (0.78–4.52) | 315(64.5%) | 153(31.4%) | 20(4.1%) | (1.06–2.38) | ||||
Common carotid | + | 381(94.1%) | 23(5.7%) | 1(0.2%) | 0.533 | 1.11 | 0.754 | 297(71.4%) | 103(24.8%) | 16(3.8%) |
0.005
| 1.63 |
0.004
|
- | 295(93.9%) | 19(6.1%) | 0(0%) | (0.57–2.16) | 201(62.0%) | 108(33.3%) | 15(4.7%) | (1.17–2.27) | |||||
(Male) | |||||||||||||
PAI | + | 136(96.5%) | 4(2.8%) | 1(0.7%) | 0.151 | 2.39 | 0.124 | 101(71.1%) | 37(26.1%) | 4(2.8%) | 0.062 | 1.23 | 0.374 |
(Female) | - | 400(93.7%) | 26(6.1%) | 1(0.2%) | (0.79–7.27) | 278(63.6%) | 139(31.8%) | 20(4.6%) | (0.78–1.93) | ||||
Common carotid | + | 285(95.6%) | 12(4.0%) | 1(0.3%) | 0.127 | 1.55 | 0.267 | 204(67.8%) | 87(28.9%) | 10(3.3%) | 0.139 | 1.25 | 0.234 |
- | 302(93.2%) | 21(6.5%) | 1(0.3%) | (0.72–3.37) | 211(63.4%) | 106(31.8%) | 16(4.8%) | (0.86–1.82) | |||||
(Female) |
Atherosclerosis degrees in each rs2229116genotype
Arteries | rs2229116 genotypes, mean(n) | |||||
---|---|---|---|---|---|---|
AA | AG | GG | Total |
p
a
|
p
b
| |
Common carotid | 7.18 (913) | 6.63 (404) | 6.42 (57) | 6.99 (1374) |
0.030
|
0.010
|
PAI | 4.29 (834) | 4.15 (376) | 3.97 (52) | 4.23 (1262) | 0.171 | 0.060 |
Relationships between RYR3 haplotypes and atherosclerosis severity
Common carotid | PAI | |||||||
---|---|---|---|---|---|---|---|---|
Haplotype | BETAa
|
p
a
| OR(95% CI)b
|
p
b
| BETAa
|
p
a
| OR(95% CI)b
|
p
b
|
TGGA | 0.34 |
0.032
| 1.16(0.99–1.36) | 0.071 | −0.18 | 0.292 | 1.07(0.89–1.28) | 0.464 |
TAGA | 0.27 | 0.194 | 1.12(0.90–1.40) | 0.314 | −0.11 | 0.611 | 1.15(0.90–1.47) | 0.265 |
TAAA | −0.25 | 0.296 | 1.02(0.75–1.39) | 0.901 | 0.50 |
0.048
| 1.19(0.91–1.55) | 0.201 |
TAGG | −0.70 |
0.007
| 0.75(0.58–0.98) |
0.034
| −0.14 | 0.603 | 0.67(0.48–0.94) |
0.020
|
TGGG | −0.61 | 0.109 | 0.61(0.41–0.90) |
0.013
| −0.09 | 0.813 | 0.75(0.47–1.22) | 0.247 |