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13.11.2023 | Retinal Disorders

Associations of quantitative contrast sensitivity with wide-field swept-source optical coherence tomography angiography in retinal vein occlusion

verfasst von: Peyman Razavi, Grace Baldwin, Filippos Vingopoulos, Itika Garg, Jack Tracy, Hannah Wescott, Hanna Choi, Rebecca Zeng, Ines Lains, Deeba Husain, Leo A. Kim, Demetrios G. Vavvas, John B. Miller

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology

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Abstract

Purpose

To investigate associations between contrast sensitivity (CS) and vascular metrics on wide-field swept-source optical coherence tomography angiography (WF-SS-OCTA) in patients with retinal vein occlusion (RVO).

Methods

This prospectively recruited, cross-sectional observational study included RVO patients who underwent quantitative CS function (qCSF) testing and WF-SS-OCTA using 3 × 3, 6 × 6, and 12 × 12 mm angiograms on the same day. The study measured several qCSF outcomes and WF-SS-OCTA vascular metrics, including vessel density (VD), vessel skeletonized density (VSD), and foveal avascular zone (FAZ). The data were analyzed using multivariable regression analysis controlling for age and central subfield thickness (CST).

Results

A total of 43 RVO eyes of 43 patients and 30 fellow eyes were included. In RVO eyes, multiple vascular metrics were associated with CS outcomes but not visual acuity (VA). On 12 × 12 images, CS thresholds at 1 cpd, 1.5 cpd, and 3 cpd were significantly associated with VD and VSD, but VA was not. When comparing standardized regression coefficients, we found that vascular metrics had a larger effect size on CS than on VA. For instance, the standardized beta coefficient for FAZ area and CS at 6 cpd (β* = − 0.46, p = 0.007) was larger than logMAR VA (β* = 0.40, p = 0.011).

Conclusion

Microvascular changes on WF-SS-OCTA in RVO had a larger effect size on CS than VA. This suggests CS may better reflect the microvascular changes of RVO compared to VA. qCSF-measured CS might be a valuable adjunct functional metric in evaluating RVO patients.
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Literatur
6.
Zurück zum Zitat Vingopoulos F, Bannerman A, Zhou P, Koch T, Wescott HE, Kim L, Vavvas D, Miller JW, Miller JB (2023) Towards the validation of quantitative contrast sensitivity as a clinical endpoint: correlations with vision-related quality of life in bilateral AMD. Br J Ophthalmol. https://​doi.​org/​10.​1136/​bjo-2023-323507 Vingopoulos F, Bannerman A, Zhou P, Koch T, Wescott HE, Kim L, Vavvas D, Miller JW, Miller JB (2023) Towards the validation of quantitative contrast sensitivity as a clinical endpoint: correlations with vision-related quality of life in bilateral AMD. Br J Ophthalmol. https://​doi.​org/​10.​1136/​bjo-2023-323507
9.
Zurück zum Zitat Rubin G (1988) Reliability and sensitivity of clinical contrast sensitivity tests. Clin Vision Sci 2:169–177 Rubin G (1988) Reliability and sensitivity of clinical contrast sensitivity tests. Clin Vision Sci 2:169–177
10.
Zurück zum Zitat Pelli D, Robson JG, Wilkins AJ (1988) The design of a new letter chart for measuring contrast sensitivity. Clin Vis Sci 2:187–199 Pelli D, Robson JG, Wilkins AJ (1988) The design of a new letter chart for measuring contrast sensitivity. Clin Vis Sci 2:187–199
11.
Zurück zum Zitat Vingopoulos F, Wai KM, Katz R, Vavvas DG, Kim LA, Miller JB (2021) Measuring the contrast sensitivity function in non-neovascular and neovascular age-related macular degeneration: the quantitative contrast sensitivity function test. J Clin Med 10. https://​doi.​org/​10.​3390/​jcm10132768 Vingopoulos F, Wai KM, Katz R, Vavvas DG, Kim LA, Miller JB (2021) Measuring the contrast sensitivity function in non-neovascular and neovascular age-related macular degeneration: the quantitative contrast sensitivity function test. J Clin Med 10. https://​doi.​org/​10.​3390/​jcm10132768
15.
Zurück zum Zitat Zeng R, Vingopoulos F, Wang M, Bannerman A, Wescott HE, Baldwin G, Katz R, Koch T, Elze T, Kim LA, Vavvas DG, Husain D, Miller JB (2023) Structure-function association between contrast sensitivity and retinal thickness (total, regional, and individual retinal layer) in patients with idiopathic epiretinal membrane. Graefes Arch Clin Exp Ophthalmol 261:631–639. https://​doi.​org/​10.​1007/​s00417-022-05819-y CrossRefPubMed Zeng R, Vingopoulos F, Wang M, Bannerman A, Wescott HE, Baldwin G, Katz R, Koch T, Elze T, Kim LA, Vavvas DG, Husain D, Miller JB (2023) Structure-function association between contrast sensitivity and retinal thickness (total, regional, and individual retinal layer) in patients with idiopathic epiretinal membrane. Graefes Arch Clin Exp Ophthalmol 261:631–639. https://​doi.​org/​10.​1007/​s00417-022-05819-y CrossRefPubMed
22.
Zurück zum Zitat Rudnick ND, Vingopoulos F, Wang JC, Garg I, Cui Y, Zhu Y, Le R, Katz R, Lu Y, Patel NA, Miller JB (2022) Characterising collateral vessels in eyes with branch retinal vein occlusions using widefield swept-source optical coherence tomography angiography. Br J Ophthalmol. https://​doi.​org/​10.​1136/​bjo-2021-320356 Rudnick ND, Vingopoulos F, Wang JC, Garg I, Cui Y, Zhu Y, Le R, Katz R, Lu Y, Patel NA, Miller JB (2022) Characterising collateral vessels in eyes with branch retinal vein occlusions using widefield swept-source optical coherence tomography angiography. Br J Ophthalmol. https://​doi.​org/​10.​1136/​bjo-2021-320356
23.
Zurück zum Zitat Mo S, Krawitz B, Efstathiadis E, Geyman L, Weitz R, Chui TY, Carroll J, Dubra A, Rosen RB (2016) Imaging foveal microvasculature: optical coherence tomography angiography versus adaptive optics scanning light ophthalmoscope fluorescein angiography. Invest Ophthalmol Vis Sci 57:130–140. https://​doi.​org/​10.​1167/​iovs.​15-18932 CrossRef Mo S, Krawitz B, Efstathiadis E, Geyman L, Weitz R, Chui TY, Carroll J, Dubra A, Rosen RB (2016) Imaging foveal microvasculature: optical coherence tomography angiography versus adaptive optics scanning light ophthalmoscope fluorescein angiography. Invest Ophthalmol Vis Sci 57:130–140. https://​doi.​org/​10.​1167/​iovs.​15-18932 CrossRef
24.
Zurück zum Zitat Cui Y, Zhu Y, Wang JC, Lu Y, Zeng R, Katz R, Vingopoulos F, Le R, Laíns I, Wu DM, Eliott D, Vavvas DG, Husain D, Miller JW, Kim LA, Miller JB (2021) Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy. Br J Ophthalmol 105:577–581. https://​doi.​org/​10.​1136/​bjophthalmol-2020-316245 CrossRefPubMed Cui Y, Zhu Y, Wang JC, Lu Y, Zeng R, Katz R, Vingopoulos F, Le R, Laíns I, Wu DM, Eliott D, Vavvas DG, Husain D, Miller JW, Kim LA, Miller JB (2021) Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy. Br J Ophthalmol 105:577–581. https://​doi.​org/​10.​1136/​bjophthalmol-2020-316245 CrossRefPubMed
31.
Zurück zum Zitat Martinez-Velazquez LA, Baldwin G, Garg I, Cui Y, Katz R, Zeng R, Duich M, Moon JY, Vingopoulos F, Wescott H, Koch T, Patel NA, Wu DM, Miller JB (2022) Predicting visual outcomes in central retinal vein occlusion (CRVO) with vascular metrics and non-perfusion area (NPA) measured by wide-field swept-source OCT-angiography (WF SS-OCTA). Invest Ophthalmol Vis Sci 63:2937-F0090 Martinez-Velazquez LA, Baldwin G, Garg I, Cui Y, Katz R, Zeng R, Duich M, Moon JY, Vingopoulos F, Wescott H, Koch T, Patel NA, Wu DM, Miller JB (2022) Predicting visual outcomes in central retinal vein occlusion (CRVO) with vascular metrics and non-perfusion area (NPA) measured by wide-field swept-source OCT-angiography (WF SS-OCTA). Invest Ophthalmol Vis Sci 63:2937-F0090
34.
Zurück zum Zitat Baldwin G, Vingopoulos F, Garg I, Moon JY, Zeng R, Cui Y, Katz R, Le R, Lu ES, Sayah DN, Hassan Z, Kim LA, Elze T, Husain D, Miller JB (2023) Structure-function associations between contrast sensitivity and widefield swept-source optical coherence tomography angiography in diabetic macular edema. Graefes Arch Clin Exp Ophthalmol. https://​doi.​org/​10.​1007/​s00417-023-06086-1 Baldwin G, Vingopoulos F, Garg I, Moon JY, Zeng R, Cui Y, Katz R, Le R, Lu ES, Sayah DN, Hassan Z, Kim LA, Elze T, Husain D, Miller JB (2023) Structure-function associations between contrast sensitivity and widefield swept-source optical coherence tomography angiography in diabetic macular edema. Graefes Arch Clin Exp Ophthalmol. https://​doi.​org/​10.​1007/​s00417-023-06086-1
Metadaten
Titel
Associations of quantitative contrast sensitivity with wide-field swept-source optical coherence tomography angiography in retinal vein occlusion
verfasst von
Peyman Razavi
Grace Baldwin
Filippos Vingopoulos
Itika Garg
Jack Tracy
Hannah Wescott
Hanna Choi
Rebecca Zeng
Ines Lains
Deeba Husain
Leo A. Kim
Demetrios G. Vavvas
John B. Miller
Publikationsdatum
13.11.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-023-06288-7