Background
Methods
Participants
Clinical assessment
Laboratory tests of blood samples
11C-Pittsburgh Compound B-PET image acquisition and preprocessing
FDG-PET image acquisition and preprocessing
Statistical analyses
Results
Demographic and clinical characteristics
CN (n = 148) | |
---|---|
Age (years) | 68.93 ± 7.85 |
Education (years) | 11.67 ± 4.85 |
Gender, female (%) | 92 (62.2) |
CDR | 0 |
APOE ε4 allele(+) (%) | 25 (16.9) |
HRSD | 0.86 ± 1.60 |
VRS | 1.07 ± 0.92 |
Neuropsychological testsa
| |
MMSE score | 26.94 ± 2.58 |
Animal fluency | 16.22 ± 4.70 |
Boston naming | 12.27 ± 2.37 |
Word list learning | 20.15 ± 4.15 |
Constructional praxis | 10.06 ± 1.37 |
Word list recall | 6.76 ± 1.83 |
Word list recognition | 9.24 ± 1.04 |
Constructional recall | 7.46 ± 2.80 |
Global amyloid burden (SUVR) | 1.16 ± 0.23 |
Amyloid positivity (%) | 16 (10.8) |
T3 (mg/dl) | 103.84 ± 17.34 |
Free T3 (pg/ml) | 3.11 ± 0.34 |
Free T4 (ng/dl) | 1.17 ± 0.16 |
TSH (μIU/ml) | 2.36 ± 1.57 |
Exploratory univariate analyses
Confirmatory multivariate analysis for global cerebral Aβ deposition
Dependent variable | Independent variable | Model Ia
| Model IIb
| ||||||
---|---|---|---|---|---|---|---|---|---|
B
| SE |
t
|
p
|
B
| SE |
t
|
p
| ||
Global cerebral Aβ deposition | Serum fT4 level | – 0.213 | 0.088 | – 2.407 | 0.017* | – 0.205 | 0.088 | – 2.316 | 0.022* |
Confirmatory multivariate analysis for CMglu
Model Ia
| Model IIb
| Model IIIc
| ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
B
| SE |
t
|
p
|
B
| SE |
t
|
p
|
B
| SE |
t
|
p
| |
AD-signature region CMglu | ||||||||||||
TSH | – 0.011 | 0.006 | – 1.677 | 0.096 | – 0.011 | 0.006 | – 1.667 | 0.098 | – 0.010 | 0.007 | – 1.486 | 0.139 |