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Erschienen in: Allergo Journal 4/2021

25.06.2021 | Asthma bronchiale | Übersicht

Der Farmeffekt revisited: vom β-Lactoglobulin mit Zink im Kuhstallstaub zur Anwendung

verfasst von: Hanna Mayerhofer, Isabella Pali-Schöll

Erschienen in: Allergo Journal | Ausgabe 4/2021

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Zusammenfassung

Hintergrund: Zahlreiche Faktoren wie Mikrobiota und deren Produkte werden im Zusammenhang mit der Hygienehypothese und dem damit assoziierten allergiepräventiven Farmeffekt diskutiert. Neben dem Einatmen der Stäube auf Bauernhöfen wirkt auch der Konsum von Rohmilch der Entstehung von Asthma und Allergien entgegen. Da besonders Rinderställe und Kuhmilch als wirksam beschrieben wurden, scheint die Beteiligung eines bovinen Proteins wahrscheinlich. β-Lactoglobulin (BLG) ist ein Hauptprotein in Milch und besitzt als Lipocalin eine intramolekulare Tasche, welche eine Bindung an hydrophobe Liganden ermöglicht.
Ergebnisse: Unsere Studien zeigen, dass unbeladenes BLG die Entstehung einer Allergie begünstigt, während beladenes, sogenanntes holo-BLG, allergiepräventiv wirkt. BLG konnte mit Zink assoziiert auch im Stallstaub und in der Umgebungsluft von Rinderfarmen nachgewiesen werden.
Schlussfolgerung: Es scheint daher naheliegend, dass zusätzlich zu Mikroben und deren Produkten auch holo-BLG eine wichtige Rolle im schützenden Farmeffekt spielt. In einer neu entwickelten Lutschtablette zum Diätmanagement bei Allergien ist Zink an holo-BLG daher, basierend auf dem Bauernhof-Effekt, einer der Schlüsselbestandteile.
Zitierweise: Mayerhofer H, Pali-Schöll I. The farm effect revisited: from β-lactoglobulin with zinc in cowshed dust to its application. Allergo J Int 2021; 30:135-40
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Metadaten
Titel
Der Farmeffekt revisited: vom β-Lactoglobulin mit Zink im Kuhstallstaub zur Anwendung
verfasst von
Hanna Mayerhofer
Isabella Pali-Schöll
Publikationsdatum
25.06.2021
Verlag
Springer Medizin
Schlagwort
Asthma bronchiale
Erschienen in
Allergo Journal / Ausgabe 4/2021
Print ISSN: 0941-8849
Elektronische ISSN: 2195-6405
DOI
https://doi.org/10.1007/s15007-021-4820-y

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