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Journal of NeuroVirology

Erschienen in:

22.01.2019

Astrocyte activation and altered metabolism in normal aging, age-related CNS diseases, and HAND

verfasst von: Bianca Cotto, Kalimuthusamy Natarajaseenivasan, Dianne Langford

Erschienen in: Journal of NeuroVirology | Ausgabe 5/2019

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Abstract

Astrocytes regulate local cerebral blood flow, maintain ion and neurotransmitter homeostasis, provide metabolic support, regulate synaptic activity, and respond to brain injury, insults, and infection. Because of their abundance, extensive connectivity, and multiple roles in the brain, astrocytes are intimately involved in normal functioning of the CNS and their dysregulation can lead to neuronal dysfunction. In normal aging, decreased biological functioning and reduced cognitive abilities are commonly experienced in individuals free of overt neurological disease. Moreover, in several age-related CNS diseases, chronic inflammation and altered metabolism have been reported. Since people with HIV (PWH) are reported to experience rapid aging with chronic inflammation, altered brain metabolism is likely to be exacerbated. In fact, many studies report altered metabolism in astrocytes in diseases such as Alzheimer’s, Parkinson’s, and HIV. This review will address the roles of astrocyte activation and altered metabolism in normal aging, in age-related CNS disease, and in HIV-associated neurocognitive disorders.

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Titel: Astrocyte activation and altered metabolism in normal aging, age-related CNS diseases, and HAND
verfasst von: Bianca Cotto
Kalimuthusamy Natarajaseenivasan
Dianne Langford
Publikationsdatum: 22.01.2019
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 5/2019
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-019-00721-6

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Astrocyte activation and altered metabolism in normal aging, age-related CNS diseases, and HAND

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