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Journal of Neural Transmission

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04.06.2016 | Translational Neurosciences - Review Article

Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease

verfasst von: Saeed Sadigh-Eteghad, Alireza Majdi, Javad Mahmoudi, Samad E. J. Golzari, Mahnaz Talebi

Erschienen in: Journal of Neural Transmission | Ausgabe 12/2016

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Abstract

It is increasingly recognized that astrocytes and microglia-associated dysfunction contribute to AD pathology. In addition, glial nicotinic acetylcholine receptors (nAChRs) play a role in AD-related phenomena, such as neuron survival, synaptic plasticity, and memory. From mechanistic point of view, the glial regulation of pro-inflammatory cytokines, as common contributors in AD, is modulated by nAChRs. Astrocytic and microglial nAChRs contribute to Aβ metabolism, including Aβ phagocytosis and degradation as well as Aβ-related oxidative stress and neurotoxicity. These receptors are also involved in neurotransmission and gliotransmission through indirect interaction with N-Methyl-d-aspartate (NMDA) and a-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) receptors as well as gamma-aminobutyric acid (GABA) and intracellular calcium regulation. In addition, glial nAChRs participate in trophic factors-induced neuroprotection. This review gathers the most recent advances along with the previous data on astrocytic and microglial nAChRs role in AD pathogenesis.

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Titel: Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease
verfasst von: Saeed Sadigh-Eteghad
Alireza Majdi
Javad Mahmoudi
Samad E. J. Golzari
Mahnaz Talebi
Publikationsdatum: 04.06.2016
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 12/2016
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-016-1580-z

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