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Erschienen in: International Journal of Clinical Pharmacy 2/2018

01.04.2018 | Short Research Report

Attention deficit hyperactivity disorder pharmacotherapy in Slovenian adults: a population-based study

verfasst von: Matej Stuhec, Igor Locatelli

Erschienen in: International Journal of Clinical Pharmacy | Ausgabe 2/2018

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Abstract

Background Pharmacotherapy is the first line treatment for adult attention deficit hyperactivity disorder (ADHD) and the percentage of treated patients may indicate the quality of treatment of adult ADHD. The main aim of this study was to investigate the rates of pharmacological treatment for adult ADHD in Slovenia from 2003 to 2015. Methods The number of prescriptions per patient was obtained for three different age groups (18–24, 25–49, 50 + age group). The national consumption rates were obtained from the national database. The only drugs that were available and were included in this study were methylphenidate (MPH) and atomoxetine (ATX). Results Between 2003 and 2015 the rate of patients aged 18–24 who were treated with MPH increased from 0.8 per 10,000 people aged 18–24 to 8.9 per 10,000 people, while the increase in the other two age groups was less substantial (25–49, 50 + age group). The rate of patients aged 18–24 treated with ATX in 2015 was 7.3 per 10,000 people and 2.2 per 10,000 people in the 25–49 age category and 0.28 in the 50 + age group category. Conclusion Prescription rates of ADHD medication have increased dramatically in the study period. The high proportion of ADHD patients treated with ATX can be explained by low adherence to treatment guidelines. This is the first study to compare ADHD pharmacotherapy across different adult age groups in this part of Europe, so the results could be widely relevant.
Literatur
1.
Zurück zum Zitat Akutagava-Martins GC, Rohde LA, Hutz MH. Genetics of attention-deficit/hyperactivity disorder: an update. Expert Rev Neurother. 2016;16:145–56.CrossRefPubMed Akutagava-Martins GC, Rohde LA, Hutz MH. Genetics of attention-deficit/hyperactivity disorder: an update. Expert Rev Neurother. 2016;16:145–56.CrossRefPubMed
2.
Zurück zum Zitat Polanczyk GV, Salum GA, Sugaya LS, Caye A, Rohde LA. Annual research review: a meta-analysis of the worldwide prevalence of mental disorders in children and adolescents. J Child Psychol Psychiatry. 2015;56:345–65.CrossRefPubMed Polanczyk GV, Salum GA, Sugaya LS, Caye A, Rohde LA. Annual research review: a meta-analysis of the worldwide prevalence of mental disorders in children and adolescents. J Child Psychol Psychiatry. 2015;56:345–65.CrossRefPubMed
3.
Zurück zum Zitat Štuhec M, Švab V, Locatelli I. Prevalence and incidence of attention-deficit/hyperactivity disorder in Slovenian children and adolescents: a database study from a national perspective. Croat Med J. 2015;56:159–65.CrossRefPubMedPubMedCentral Štuhec M, Švab V, Locatelli I. Prevalence and incidence of attention-deficit/hyperactivity disorder in Slovenian children and adolescents: a database study from a national perspective. Croat Med J. 2015;56:159–65.CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Stuhec M. Pharmacotherapy of ADHD in Slovenia: realities and perspectives. Eur Child Adolesc Psychiatry. 2016;25:455–7.CrossRefPubMed Stuhec M. Pharmacotherapy of ADHD in Slovenia: realities and perspectives. Eur Child Adolesc Psychiatry. 2016;25:455–7.CrossRefPubMed
5.
Zurück zum Zitat Bolea-Alamañac B, Nutt DJ, Adamou M, Asherson P, Bazire S, Coghill D, et al. Evidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: update on recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 2014;28:179–203.CrossRefPubMed Bolea-Alamañac B, Nutt DJ, Adamou M, Asherson P, Bazire S, Coghill D, et al. Evidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: update on recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 2014;28:179–203.CrossRefPubMed
6.
Zurück zum Zitat Stuhec M, Munda B, Svab V, Locatelli I. Comparative efficacy and acceptability of atomoxetine, lisdexamfetamine, bupropion and methylphenidate in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysis with focus on bupropion. J Affect Disord. 2015;178:149–59.CrossRefPubMed Stuhec M, Munda B, Svab V, Locatelli I. Comparative efficacy and acceptability of atomoxetine, lisdexamfetamine, bupropion and methylphenidate in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysis with focus on bupropion. J Affect Disord. 2015;178:149–59.CrossRefPubMed
7.
Zurück zum Zitat Faraone SV. Using meta-analysis to compare the efficacy of medications for attention-deficit/hyperactivity disorder in youths. P T. 2009;34:678–94.PubMedPubMedCentral Faraone SV. Using meta-analysis to compare the efficacy of medications for attention-deficit/hyperactivity disorder in youths. P T. 2009;34:678–94.PubMedPubMedCentral
8.
Zurück zum Zitat Faraone SV, Biederman J, Spencer TJ, Aleardi M. Comparing the efficacy of medications for ADHD using meta-analysis. Med Gen Med. 2006;8:4. Faraone SV, Biederman J, Spencer TJ, Aleardi M. Comparing the efficacy of medications for ADHD using meta-analysis. Med Gen Med. 2006;8:4.
9.
Zurück zum Zitat Roskell NS, Setyawan J, Zimovetz EA, Hodgkins P. Systematic evidence synthesis of treatments for ADHD in children and adolescents: indirect treatment comparisons of lisdexamfetamine with methylphenidate and atomoxetine. Curr Med Res Opin. 2014;30:1673–85.CrossRefPubMed Roskell NS, Setyawan J, Zimovetz EA, Hodgkins P. Systematic evidence synthesis of treatments for ADHD in children and adolescents: indirect treatment comparisons of lisdexamfetamine with methylphenidate and atomoxetine. Curr Med Res Opin. 2014;30:1673–85.CrossRefPubMed
10.
Zurück zum Zitat Štuhec M, Locatelli I, Švab V. Trends in attention-deficit/hyperactivity disorder drug consumption in children and adolescents in slovenia from 2001 to 2012: a drug use study from a national perspective. J Child Adolesc Psychopharmacol. 2015;25:254–9.CrossRefPubMed Štuhec M, Locatelli I, Švab V. Trends in attention-deficit/hyperactivity disorder drug consumption in children and adolescents in slovenia from 2001 to 2012: a drug use study from a national perspective. J Child Adolesc Psychopharmacol. 2015;25:254–9.CrossRefPubMed
11.
Zurück zum Zitat Schubert I, Köster I, Lehmkuhl G. The changing prevalence of attention-deficit/hyperactivity disorder and methylphenidate prescriptions: a study of data from a random sample of insurees of the AOK Health Insurance Company in the German State of Hesse, 2000–2007. Dtsch Arztebl Int. 2010;107:615–21.PubMedPubMedCentral Schubert I, Köster I, Lehmkuhl G. The changing prevalence of attention-deficit/hyperactivity disorder and methylphenidate prescriptions: a study of data from a random sample of insurees of the AOK Health Insurance Company in the German State of Hesse, 2000–2007. Dtsch Arztebl Int. 2010;107:615–21.PubMedPubMedCentral
12.
Zurück zum Zitat Renoux C, Shin JY, Dell’Aniello S, Fergusson E, Suissa S. Prescribing trends of attention-deficit hyperactivity disorder (ADHD) medications in UK primary care, 1995–2015. Br J Clin Pharmacol. 2016;82:858–68.CrossRefPubMedPubMedCentral Renoux C, Shin JY, Dell’Aniello S, Fergusson E, Suissa S. Prescribing trends of attention-deficit hyperactivity disorder (ADHD) medications in UK primary care, 1995–2015. Br J Clin Pharmacol. 2016;82:858–68.CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat van den Ban E, Souverein P, Swaab H, van Engeland H, Heerdink R, Egberts T. Trends in incidence and characteristics of children, adolescents, and adults initiating immediate-or extended-release methylphenidate or atomoxetine in the Netherlands during 2001–2006. J Child Adolesc Psychopharmacol. 2010;20:55–61.CrossRefPubMed van den Ban E, Souverein P, Swaab H, van Engeland H, Heerdink R, Egberts T. Trends in incidence and characteristics of children, adolescents, and adults initiating immediate-or extended-release methylphenidate or atomoxetine in the Netherlands during 2001–2006. J Child Adolesc Psychopharmacol. 2010;20:55–61.CrossRefPubMed
14.
Zurück zum Zitat Stuhec M, Locatelli I. Age-related pharmacotherapy of attention deficit hyperactivity disorder in Slovenia in children and adolescents: a population-based study. Eur Psychiatry. 2017;42:129–33.CrossRefPubMed Stuhec M, Locatelli I. Age-related pharmacotherapy of attention deficit hyperactivity disorder in Slovenia in children and adolescents: a population-based study. Eur Psychiatry. 2017;42:129–33.CrossRefPubMed
Metadaten
Titel
Attention deficit hyperactivity disorder pharmacotherapy in Slovenian adults: a population-based study
verfasst von
Matej Stuhec
Igor Locatelli
Publikationsdatum
01.04.2018
Verlag
Springer International Publishing
Erschienen in
International Journal of Clinical Pharmacy / Ausgabe 2/2018
Print ISSN: 2210-7703
Elektronische ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-018-0605-0

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