Background
Principle | Criteria for this review | Example |
---|---|---|
Specificity: Training adaptations are specific to the organ system or muscles trained with exercise | Appropriate population targeted and modality selected based on primary outcome | Aerobic exercise such as brisk walking is more appropriate for an intervention aimed at increasing cardiovascular fitness than strength training |
Progression: Over time, the body adapts to exercise. For continued improvement, the volume or intensity of training must be increased | Stated exercise programme was progressive and outlined training progression | Increase duration of walking program by 5% every two weeks depending on exercise tolerance |
Overload: For an intervention to improve fitness, the training volume must exceed current habitual physical activity and/or training levels | Rationale provided that programme was of sufficient intensity/exercise prescribed relative to baseline capacity | Prescribing intensity in a resistance training program based on % of measured and/or estimated 1-repetition maximum |
Initial values: Improvements in the outcome of interest will be greatest in those with lower initial values | Selected population with low level of primary outcome measure and/or baseline physical activity levels | Selecting a sample with high baseline fatigue levels to participate in an aerobic training program to increase cardiovascular fitness and reduce fatigue |
Reversibility: Once a training stimulus is removed, fitness levels will eventually return to baseline | Performed follow-up assessment on participants who decreased or stopped exercise training after conclusion of intervention | Participants who maintained training after a supervised exercise program preserved strength whereas those who stopped exercising returned to baseline |
Diminishing returns: The expected degree of improvement in fitness decreases as individuals become more fit, thereby increasing the effort required for further improvements. Also known as the ‘ceiling effect’ | Performed follow-up assessment of primary outcomes on participants who continued to exercise after conclusion of intervention | Gains in muscle strength are greatest in the first half of a training program unless the training stimulus continually increases |
Methods
Results
Authors, Year | Timing | Treatment | N | Intervention | Length (weeks) | Follow-up(weeks) | Primary Outcome* (Tool) | Other Outcomes (Tool) |
---|---|---|---|---|---|---|---|---|
Aerobic Exercise Only | ||||||||
Eriksen et al, 2017 [26] | During | AS | 26 | Home | 26 | 12, 37, 52 | NR | VO2 peak (max cycle), lipids, insulin, glucose, PSA, FFM, FM, BMI, WC |
Hvid et al, 2016 [27] | Mixed | AS or RP | 25 | Home | 104 | 12, 24, 36, 52, 78 | NR | VO2 peak (max cycle), BC (DXA), HOMA-IR (OGTT), TC, LDL, HDL, TG, TNF-α, IL-6, adiponectin, leptin, IGF-1, IGFBP-1, glucose, PSA |
Jones et al, 2014 [28] | Mixed | RP | 50 | Sup + Home | 26 | 12, 52 | Erectile Function (IIEF) | VO2 peak (max TM), peripheral artery FMD, glucose, TC, TG, BC (BodPod) |
Monga et al, 2007 [22] | During | RT | 21 | Sup | 8 | – | Fatigue (PFS) | VO2 peak (submax TM), strength (sit-stand) |
Pernar et al, 2017 [29] | After | Mixed | 41 | Sup + Home | 11 | – | NR | BW, WC, BP, CRP, C-peptide, HDL, LDL, testosterone, SHBG |
Uth et al, 2014 [30] | During | ADT | 57 | Sup | 12 | 32 | LBM (DXA) | BMD, BMC, FM (DXA), BW, BMI, WC, HC, WHR, VO2 peak (submax TM), sit-stand, counter-movement jump, stair climb, strength (1RM, knee ext), bone markers |
Windsor et al, 2004 [25] | During | RT | 66 | Home | 4 | – | Fatigue (BFI), Aer fitness (Shuttle walk) | NR |
Resistance Exercise Only | ||||||||
Nilsen et al, 2015 [31] | During | ADT | 58 | Sup + Home | 16 | – | NR | LBM, BMD, FM, %BF, BW, BMI (DXA), 1RM (knee ext., leg, chest, shoulder press), sit-stand, stair climb, aer fitness (shuttle walk); muscle cell markers, fiber |
Norris et al, 2015 [32] | Mixed | Mixed | 30 | Sup (High) | 12 | – | Strength (est 1RM, bench press, leg press) | Physical function (6MWT, 8 ft. TUG, 30s chair stands, 30s arm curls, S&R, back scratch); BW, BMI, |
Sup (Low) | ||||||||
Segal et al, 2003 [23] | During | ADT | 155 | Sup | 12 | – | Fatigue (FACT-F) | Muscle endurance (Standard Load), BW, BMI, WC (SkF) |
Winters-Stone et al, 2014 [33] | During | ADT | 51 | Sup + Home | 52 | – | BMD (DXA) | Bone turnover, LM, FM (DXA), insulin, IGF-1, SHBG, testosterone, strength (1RM, leg and chest press), physical function (5 chair stand time, 4 m walk speed) |
Winters-Stone et al, 2016 [34] | After | RT ± CT | 64 | Sup | 24 | 12 | Function (SPPB), MM, FM, %BF (DXA), fatigue (PFS), QoL (SF-36), strength (1RM leg, bench press) | NR |
Aerobic + Resistance Exercise | ||||||||
Bourke et al, 2011 [19] | During | ADT | 100 | Sup + Home | 12 | 6, 24 | QoL (FACT-P), DBP | VO2 peak (submax TM), strength (Iso-dyn, subgroup), BMI, IGF-1, IGFBP-1, IGFBP-3, insulin, PSA, androgen, testosterone, SHBG; Subgroup: Brachial artery FMD, GTN-mediated brachial artery dilation |
Cormie et al, 2015 [35] | During | ADT | 63 | Sup | 12 | – | LM, FM (DXA) | BMD (DXA), aer fitness (400 m walk), strength (1RM leg press, chest press, seated row), chair stand, stair climb, BP, CRP, TC, TG, insulin, glucose, HbA1C, bone turnover, vitamin D, testosterone, PSA |
Culos-Reed et al, 2010 [20] | During | ADT | 100 | Sup + Home | 16 | 8, 26 | SR-PA (Godin) | Aer fitness (6MWT), strength (Iso-dyn), S&R, BP, HR |
Galvao et al, 2010 [21] | During | ADT | 57 | Sup | 12 | – | LBM, FM, %BF (DXA) | Strength (1RM), Endurance (Time at 70% 1RM), physical function (sit-stand, 6 & 400 m walk), testosterone, PSA, insulin, glucose, lipids, CRP |
Galvao et al, 2014 [36] | After | ADT + RT | 100 | Sup + Home | 52 | 26 | Aer fitness (400 m walk) | Physical function (chair stands), WC, testosterone, PSA, insulin, TC, TG, LDL, HDL, HbA1C, glucose, BP Subgroup: Strength (1 RM, chest and leg press), FM, %BF, adiposity (DXA) |
Gaskin et al, 2017 [37] | After | Mixed | 320 | Sup + Home | 12 | 26, 52 | SR-PA (LTEQ) | RHR, BP, aer fitness (6MWT), strength (1RM), physical function (30s sit-stand), BW, BMI, WC, HC, upper arm, chest, thigh circumference |
Hojan et al, 2016 [38] | During | RT + ADT | 55 | Sup | 8 | – | NR | PSA, Hb, WBC, RBC, neutrophil, lymphocytes, platelets, monocytes, IL-B, IL-6, TNF-α, Aer fitness (6MWT) |
Hojan et al, 2017 [39] | During | RT + ADT | 72 | Sup | 52 | 8 | Aer fitness (6MWT), IL-1B, IL-6, TNF-a, BMI, WHR, WC, TC, HDL, LDL, TG, AST, ALT | NR |
Kim, 2018 [40] | During | ADT | 51 | Home | 24 | – | BMD (DXA), Bone turnover markers (bs-ALP, NTx) | Strength (grip, hip, HHD), 30s chair-stand, TUG |
Sajid et al, 2016 [41] | During | ADT | 19 | Home | 6 | 12 | Function (SPPB) | Aer fitness (6MWT), strength (grip, chest press reps), FM, LM, MM (DXA) |
Technology | ||||||||
Aerobic or Resistance Exercise (Multi-Arm Trials) | ||||||||
Santa Mina et al, 2013 [42] | During | ADT | 26 | Sup + Home Aer | 24 | 12, 52 | QoL (FACT-P, Patient-Oriented Prostate Utility Scale), Fatigue (FACT-F) | VO2 peak (Submax TM), grip strength, BW, BMI, %BF, WC, IGF-1, IGFBP-3, leptin, adiponectin |
Sup + Home Res | ||||||||
Segal et al, 2009 [24] | During | RT | 121 | Sup Aer | 24 | – | Fatigue (FACT-F) | VO2 peak (max TM), strength (8RM), BW, BC (DXA), testosterone, PSA, Hb, lipids |
Sup Res | ||||||||
Wall et al, 2017 [43] | During | ADT | 163 | Sup + Home Aer + Res | 52 (26) | – | BMD (DXA), LM, FM, Trunk fat, % BF, (DXA), VO2 peak (Max TM) | RMR, BP, arterial stiffness, HbA1C, testosterone, insulin, PSA, TG, LDL, HDL, TC, glucose, CRP, bs-ALP, PINP, BW, strength (1-RM), endurance (#reps @ 70% 1RM, chest & leg press), chair stands, stair climb, 6 m backward walk, 400 m walk time |
Sup + Home Impact + Res | ||||||||
Home Aer | 26 | – |
Application of the principles of exercise training
Authors, Year | Sp | Pr | OV | IV | Rev | DR | Significant results |
---|---|---|---|---|---|---|---|
Aerobic Exercise Only | |||||||
Eriksen et al, 2017 [26] | NR | NR | NR | NR | ? | ? | ↑VO2 peak (6mo only) |
Hvid et al, 2016 [27] | ? | + | + | + | ? | ? | 6 mo: ↑VO2 peak, adiponectin, IGFBP-1; ↓FM, trunk mass, gynoid FM, android fat; 24 mo: ↓ FM, trunk mass, gynoid FM, android fat, TG, IGF-1, glucose |
Jones et al, 2014 [28] | + | + | + | + | ? | ? | ↑FMD, VO2 peak |
Monga et al, 2007 [22] | + | ? | + | NR | NR | NR | ↑ VO2 peak, Strength; ↓ Fatigue* |
Pernar et al, 2017 [29] | NR | NR | NR | NR | NR | NR | ↑ HDL |
Uth et al, 2014 [30] | NR | + | NR | + | ? | ? | EoS: ↑LBM*, strength, BMC, P1NP, osteocalcin; 32 w: ↑BMD, counter jump, stair climb |
Windsor et al, 2004 [25] | + | NR | ? | NR | ? | ? | ↑ Aer fitness* |
Resistance Exercise Only | |||||||
Nilsen et al, 2015 [31] | + | + | + | + | NR | NR | ↑Muscle fiber cross-sectional area, strength (leg ext., leg, chest, shoulder press), sit-stand; LBM (lower & upper)* |
Norris et al, 2015 (High) [32] | + | + | + | + | NR | NR | No between group difference |
Norris et al, 2015 (Low) [32] | + | + | + | + | NR | NR | No between group difference |
Segal et al, 2003 [23] | + | + | + | NR | NR | NR | ↓ Fatigue*; ↑Muscle endurance |
Winters-Stone et al, 2014 [33] | + | + | + | + | NR | ? | ↓ FM, ↑strength |
Winters-Stone et al, 2016 [34] | + | + | + | + | NR | + | ↑Upper body strength* |
Aerobic and Resistance Exercise | |||||||
Bourke et al, 2011 [19] | + | + | NR | + | ? | ? | ↑QoL (12w only)*; VO2 peak, strength, FMD, skeletal MM, SHBG (subgroup only) |
Cormie et al, 2015 [35] | + | + | NR | + | NR | NR | ↑Appendicular LM*, Aer fit, strength, chair stands; ↓ FM*, % BF*, TC |
Culos-Reed et al, 2010 [20] | + | NR | NR | NR | NR | NR | ↑ SR-PA* |
Galvao et al, 2010 [21] | + | ? | ? | NR | NR | NR | ↑ LBM*, Strength, Endurance, 6 m walk; ↓ CRP |
Galvao et al, 2014 [36] | + | ? | NR | + | NR | + | ↑ Aer fitness*, chair stands, strength (6 & 12 mo); appendicular MM (6 mo only), HDL; ↓ TC (12 mo only) |
Gaskin et al, 2017 [37] | + | ? | NR | NR | ? | ? | ↑ Vigorous SR-PA (12wk & 6 mo only)*; Aer fitness, strength, sit-stand; ↓ HC, RHR (12w only) |
Hojan et al, 2016 [38] | + | NR | NR | + | NR | NR | ↑Aer fitness |
Hojan et al, 2017 [39] | + | ? | NR | + | NR | + | ↓ BW, BMI*, WHR*, PSA, IL-6*, ↑ Aer fitness* |
Kim et al, 2018 [40] | + | + | + | + | NR | NR | ↑ Grip strength (left hand), 30s chair stands |
Sajid et al, 2016 (Home) [41] | ? | NR | NR | NR | NR | NR | ↑ SPPB (vs. control)* |
Sajid et al, 2016 (Tech) [41] | ? | NR | NR | NR | NR | NR | None |
Aerobic or Resistance Exercise (Multi-Arm Trials) | |||||||
Santa Mina et al, 2013 (Aer) [42] | + | NR | NR | NR | ? | + | ↓ BW, WC, BMI (3 mo only) |
Santa Mina et al, 2013 (Res) [42] | + | NR | NR | NR | ? | + | ↑ IGFBP-3 (6 mo only) |
Sega et al, 2009 (Aer) [24] | + | + | + | NR | NR | NR | ↑ VO2 peak |
Segal et al, 2009 (Res) [24] | + | + | + | NR | NR | NR | ↑ VO2 peak, Strength; No %BF; ↓ TG |
Wall et al, 2017 (Aer + Res) | + | + | + | + | NR | + | ↑ Strength (6 mo only); Vs. control only: ↑VO2 peak, LM*; ↓ glucose, FM*, trunk FM*, % BF* |
Wall et al, 2017 (Impact + Res) [43] | + | + | + | + | NR | + | ↑ Strength (6, 12 mo) |
Wall et al, 2017 (Aer) [43] | + | + | + | + | NR | + | None |