Skip to main content
Erschienen in: European Child & Adolescent Psychiatry 10/2016

26.02.2016 | Original Contribution

Attenuated psychotic and basic symptom characteristics in adolescents with ultra-high risk criteria for psychosis, other non-psychotic psychiatric disorders and early-onset psychosis

verfasst von: Nella Lo Cascio, Riccardo Saba, Marta Hauser, Ditte Lammers Vernal, Aseel Al-Jadiri, Yehonatan Borenstein, Eva M. Sheridan, Taishiro Kishimoto, Marco Armando, Stefano Vicari, Paolo Fiori Nastro, Paolo Girardi, Eva Gebhardt, John M. Kane, Andrea Auther, Ricardo E. Carrión, Barbara A. Cornblatt, Benno G. Schimmelmann, Frauke Schultze-Lutter, Christoph U. Correll

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 10/2016

Einloggen, um Zugang zu erhalten

Abstract

While attenuated psychotic symptoms (APS) and basic symptoms (BS) are the main current predictors of psychosis in adults, studies in adolescents are scarce. Thus, we (1) described the prevalence and severity of positive, negative, disorganization, general, and basic symptoms in adolescent patients at ultra-high risk for psychosis (UHR), with other non-psychotic psychiatric disorders (PC) and with early-onset psychosis (EOP); and (2) investigated BS criteria in relation to UHR criteria. Sixty-nine 12–18-year-old adolescents (15.3 ± 1.7 years, female = 58.0 %, UHR = 22, PC = 27, EOP = 20) were assessed with the structured interview for prodromal syndromes (SIPS) and the schizophrenia proneness instrument-child and youth version (SPI-CY). Despite similar current and past 12-month global functioning, both UHR and EOP had significantly higher SIPS total and subscale scores compared to PC, with moderate-large effect sizes. Expectedly, UHR had significantly lower SIPS positive symptom scores than EOP, but similar SIPS negative, disorganized, and general symptom scores. Compared to PC, both EOP and UHR had more severe basic thought and perception disturbances, and significantly more often met cognitive disturbances criteria (EOP = 50.0 %, UHR = 40.9 %, PC = 14.8 %). Compared to UHR, both EOP and PC significantly less often met cognitive-perceptive BS criteria (EOP = 35.0 %, UHR = 68.2 %, PC = 25.9 %). BS were significantly more prevalent in both EOP and UHR than PC, and UHR were similar to EOP in symptom domains. Given the uncertain outcome of adolescents at clinical high-risk of psychosis, future research is needed to determine whether the combined assessment of early subjective disturbances with observable APS can improve the accuracy of psychosis prediction.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
2.
Zurück zum Zitat Schimmelmann BG, Walger P, Schultze-Lutter F (2013) The significance of at-risk symptoms for psychosis in children and adolescents. Can J Psychiatry 58:32–40PubMed Schimmelmann BG, Walger P, Schultze-Lutter F (2013) The significance of at-risk symptoms for psychosis in children and adolescents. Can J Psychiatry 58:32–40PubMed
3.
Zurück zum Zitat Schimmelmann BG, Schultze-Lutter F (2012) Early detection and intervention of psychosis in children and adolescents: urgent need for studies. Eur Child Adolesc Psychiatry 21:239–241CrossRefPubMed Schimmelmann BG, Schultze-Lutter F (2012) Early detection and intervention of psychosis in children and adolescents: urgent need for studies. Eur Child Adolesc Psychiatry 21:239–241CrossRefPubMed
5.
Zurück zum Zitat Yung AR, Nelson B (2013) The ultra-high risk concept—a review. Can J Psychiatry 58:5–12PubMed Yung AR, Nelson B (2013) The ultra-high risk concept—a review. Can J Psychiatry 58:5–12PubMed
6.
Zurück zum Zitat Klosterkötter J, Hellmich M, Steinmeyer EM, Schultze-Lutter F (2001) Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry 58:158–164CrossRefPubMed Klosterkötter J, Hellmich M, Steinmeyer EM, Schultze-Lutter F (2001) Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry 58:158–164CrossRefPubMed
7.
Zurück zum Zitat Schultze-Lutter F, Klosterkötter J, Picker H et al (2007) Predicting first-episode psychosis by basic symptom criteria. Clin Neuropsychiatry 4:11–22 Schultze-Lutter F, Klosterkötter J, Picker H et al (2007) Predicting first-episode psychosis by basic symptom criteria. Clin Neuropsychiatry 4:11–22
9.
Zurück zum Zitat Gross G (1989) The “basic” symptoms of schizophrenia. Br J Psychiatry Suppl 21–25 (discussion 37–40) Gross G (1989) The “basic” symptoms of schizophrenia. Br J Psychiatry Suppl 21–25 (discussion 37–40)
11.
Zurück zum Zitat Schimmelmann BG, Michel C, Martz-Irngartinger A et al (2015) Age matters in the prevalence and clinical significance of ultra-high-risk for psychosis symptoms and criteria in the general population: findings from the BEAR and BEARS-kid studies. World Psychiatry 14:189–197. doi:10.1002/wps.20216 CrossRefPubMedPubMedCentral Schimmelmann BG, Michel C, Martz-Irngartinger A et al (2015) Age matters in the prevalence and clinical significance of ultra-high-risk for psychosis symptoms and criteria in the general population: findings from the BEAR and BEARS-kid studies. World Psychiatry 14:189–197. doi:10.​1002/​wps.​20216 CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Gerstenberg M, Hauser M, Al-Jadiri A et al (2015) Frequency and correlates of DSM-5 attenuated psychosis syndrome in a sample of adolescent inpatients with nonpsychotic psychiatric disorders. J Clin Psychiatry 76:e1449–e1458. doi:10.4088/JCP.14m09435 CrossRefPubMed Gerstenberg M, Hauser M, Al-Jadiri A et al (2015) Frequency and correlates of DSM-5 attenuated psychosis syndrome in a sample of adolescent inpatients with nonpsychotic psychiatric disorders. J Clin Psychiatry 76:e1449–e1458. doi:10.​4088/​JCP.​14m09435 CrossRefPubMed
13.
Zurück zum Zitat Ruhrmann S, Schultze-Lutter F, Salokangas RK et al (2010) Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study. Arch Gen Psychiatry 67:241–251CrossRefPubMed Ruhrmann S, Schultze-Lutter F, Salokangas RK et al (2010) Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study. Arch Gen Psychiatry 67:241–251CrossRefPubMed
16.
Zurück zum Zitat Schultze-Lutter F, Ruhrmann S, Fusar-Poli P et al (2012) Basic symptoms and the prediction of first-episode psychosis. Curr Pharm Des 18:351–357CrossRefPubMed Schultze-Lutter F, Ruhrmann S, Fusar-Poli P et al (2012) Basic symptoms and the prediction of first-episode psychosis. Curr Pharm Des 18:351–357CrossRefPubMed
17.
Zurück zum Zitat Schultze-Lutter F, Marshall M, Koch E (2012) Schizophrenia proneness instrument, child and youth version (SPI-CY)—extended english translation. Giovanni Fioriti Editore, Rome Schultze-Lutter F, Marshall M, Koch E (2012) Schizophrenia proneness instrument, child and youth version (SPI-CY)—extended english translation. Giovanni Fioriti Editore, Rome
18.
Zurück zum Zitat Schultze-Lutter F, Koch E (2010) Strumento di valutazione per la propensione alla schizofrenia. Versione per bambini e adolescenti. Giovanni Fioriti Editore, Rome Schultze-Lutter F, Koch E (2010) Strumento di valutazione per la propensione alla schizofrenia. Versione per bambini e adolescenti. Giovanni Fioriti Editore, Rome
19.
Zurück zum Zitat Koch E, Schultze-Lutter F, Schimmelmann BG, Resch F (2010) On the importance and detection of prodromal symptoms from the perspective of child and adolescent psychiatry. Clin Neuropsychiatry 7:38–48 Koch E, Schultze-Lutter F, Schimmelmann BG, Resch F (2010) On the importance and detection of prodromal symptoms from the perspective of child and adolescent psychiatry. Clin Neuropsychiatry 7:38–48
20.
Zurück zum Zitat Schultze-Lutter F, Steinmeyer EM, Ruhrmann S, Klosterkötter J (2008) The dimensional structure of self-reported “prodromal” disturbances in schizophrenia. Clin Neuropsychiatry 5:140–150 Schultze-Lutter F, Steinmeyer EM, Ruhrmann S, Klosterkötter J (2008) The dimensional structure of self-reported “prodromal” disturbances in schizophrenia. Clin Neuropsychiatry 5:140–150
22.
Zurück zum Zitat McGlashan TH, Miller TJ, Woods SW et al (2003) Structured interview for prodromal syndromes, version 4.0. Yale School of Medicine, New Haven McGlashan TH, Miller TJ, Woods SW et al (2003) Structured interview for prodromal syndromes, version 4.0. Yale School of Medicine, New Haven
23.
Zurück zum Zitat First MB, Spitzer R, Gibbon M, Williams JBW (1996) Structured clinical interview for DSM-IV disorders. American Psychiatric Press Inc., Washington First MB, Spitzer R, Gibbon M, Williams JBW (1996) Structured clinical interview for DSM-IV disorders. American Psychiatric Press Inc., Washington
24.
Zurück zum Zitat Kaufman J, Birmaher B, Brent D et al (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988CrossRefPubMed Kaufman J, Birmaher B, Brent D et al (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988CrossRefPubMed
25.
Zurück zum Zitat Miller TJ, McGlashan TH, Rosen JL et al (2003) Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull 29:703–715CrossRefPubMed Miller TJ, McGlashan TH, Rosen JL et al (2003) Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull 29:703–715CrossRefPubMed
26.
Zurück zum Zitat Hall RCW (1995) Global assessment of functioning: a modified scale. Psychosomatics 36:267–275CrossRefPubMed Hall RCW (1995) Global assessment of functioning: a modified scale. Psychosomatics 36:267–275CrossRefPubMed
28.
Zurück zum Zitat Rosenthal R, Rosnow RL (1991) Essentials of behavioral research: methods and data analysis, 2nd edn. McGraw Hill, New York Rosenthal R, Rosnow RL (1991) Essentials of behavioral research: methods and data analysis, 2nd edn. McGraw Hill, New York
30.
Zurück zum Zitat Resch F, Koch E, Möhler E et al (2002) Early detection of psychotic disorders in adolescents: specificity of basic symptoms in psychiatric patient samples. Psychopathology 35:259–266. doi:10.1159/000067069 CrossRefPubMed Resch F, Koch E, Möhler E et al (2002) Early detection of psychotic disorders in adolescents: specificity of basic symptoms in psychiatric patient samples. Psychopathology 35:259–266. doi:10.​1159/​000067069 CrossRefPubMed
33.
Zurück zum Zitat Cannon TD, Cadenhead K, Cornblatt B et al (2008) Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Arch Gen Psychiatry 65:28–37CrossRefPubMedPubMedCentral Cannon TD, Cadenhead K, Cornblatt B et al (2008) Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Arch Gen Psychiatry 65:28–37CrossRefPubMedPubMedCentral
34.
Zurück zum Zitat Salokangas RKR, Ruhrmann S, von Reventlow HG et al (2012) Axis I diagnoses and transition to psychosis in clinical high-risk patients EPOS project: prospective follow-up of 245 clinical high-risk outpatients in four countries. Schizophr Res 138:192–197. doi:10.1016/j.schres.2012.03.008 CrossRefPubMed Salokangas RKR, Ruhrmann S, von Reventlow HG et al (2012) Axis I diagnoses and transition to psychosis in clinical high-risk patients EPOS project: prospective follow-up of 245 clinical high-risk outpatients in four countries. Schizophr Res 138:192–197. doi:10.​1016/​j.​schres.​2012.​03.​008 CrossRefPubMed
36.
Zurück zum Zitat Fusar-Poli P, Bechdolf A, Taylor MJ et al (2013) At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk. Schizophr Bull 39:923–932CrossRefPubMed Fusar-Poli P, Bechdolf A, Taylor MJ et al (2013) At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk. Schizophr Bull 39:923–932CrossRefPubMed
40.
Zurück zum Zitat Demjaha A, Valmaggia L, Stahl D et al (2012) Disorganization/cognitive and negative symptom dimensions in the at-risk mental state predict subsequent transition to psychosis. Schizophr Bull 38:351–359. doi:10.1093/schbul/sbq088 CrossRefPubMed Demjaha A, Valmaggia L, Stahl D et al (2012) Disorganization/cognitive and negative symptom dimensions in the at-risk mental state predict subsequent transition to psychosis. Schizophr Bull 38:351–359. doi:10.​1093/​schbul/​sbq088 CrossRefPubMed
43.
Zurück zum Zitat Fusar-Poli P, Hobson R, Raduelli M, Balottin U (2012) Reliability and validity of the comprehensive assessment of the at risk mental state, Italian version (CAARMS-I). Curr Pharm Des 18:386–391CrossRefPubMed Fusar-Poli P, Hobson R, Raduelli M, Balottin U (2012) Reliability and validity of the comprehensive assessment of the at risk mental state, Italian version (CAARMS-I). Curr Pharm Des 18:386–391CrossRefPubMed
51.
Zurück zum Zitat Correll CU, Blader JC (2015) Antipsychotic use in youth without psychosis: a double-edged sword. JAMA Psychiatry 72:859–860CrossRefPubMed Correll CU, Blader JC (2015) Antipsychotic use in youth without psychosis: a double-edged sword. JAMA Psychiatry 72:859–860CrossRefPubMed
52.
Zurück zum Zitat Finnerty M, Neese-Todd S, Pritam R et al (2016) Access to psychosocial services prior to starting antipsychotic treatment among medicaid-insured youth. J Am Acad Child Adolesc Psychiatry 55(69–76):e3. doi:10.1016/j.jaac.2015.09.020 PubMed Finnerty M, Neese-Todd S, Pritam R et al (2016) Access to psychosocial services prior to starting antipsychotic treatment among medicaid-insured youth. J Am Acad Child Adolesc Psychiatry 55(69–76):e3. doi:10.​1016/​j.​jaac.​2015.​09.​020 PubMed
53.
Zurück zum Zitat Maher AR, Maglione M, Bagley S et al (2011) Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA 306:1359–1369. doi:10.1001/jama.2011.1360 CrossRefPubMed Maher AR, Maglione M, Bagley S et al (2011) Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA 306:1359–1369. doi:10.​1001/​jama.​2011.​1360 CrossRefPubMed
55.
Zurück zum Zitat Correll CU (2008) Assessing and maximizing the safety and tolerability of antipsychotics used in the treatment of children and adolescents. J Clin Psychiatry 69(Suppl 4):26–36PubMed Correll CU (2008) Assessing and maximizing the safety and tolerability of antipsychotics used in the treatment of children and adolescents. J Clin Psychiatry 69(Suppl 4):26–36PubMed
59.
Zurück zum Zitat Manninen M, Lindgren M, Therman S et al (2014) Clinical high-risk state does not predict later psychosis in a delinquent adolescent population. Early Interv Psychiatry 8:87–90. doi:10.1111/eip.12045 CrossRefPubMed Manninen M, Lindgren M, Therman S et al (2014) Clinical high-risk state does not predict later psychosis in a delinquent adolescent population. Early Interv Psychiatry 8:87–90. doi:10.​1111/​eip.​12045 CrossRefPubMed
Metadaten
Titel
Attenuated psychotic and basic symptom characteristics in adolescents with ultra-high risk criteria for psychosis, other non-psychotic psychiatric disorders and early-onset psychosis
verfasst von
Nella Lo Cascio
Riccardo Saba
Marta Hauser
Ditte Lammers Vernal
Aseel Al-Jadiri
Yehonatan Borenstein
Eva M. Sheridan
Taishiro Kishimoto
Marco Armando
Stefano Vicari
Paolo Fiori Nastro
Paolo Girardi
Eva Gebhardt
John M. Kane
Andrea Auther
Ricardo E. Carrión
Barbara A. Cornblatt
Benno G. Schimmelmann
Frauke Schultze-Lutter
Christoph U. Correll
Publikationsdatum
26.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Child & Adolescent Psychiatry / Ausgabe 10/2016
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-016-0832-7

Weitere Artikel der Ausgabe 10/2016

European Child & Adolescent Psychiatry 10/2016 Zur Ausgabe

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.