Skip to main content
Erschienen in: Neurological Sciences 6/2019

11.02.2019 | Brief Communication

Attenuation of ALS progression during pregnancy—lessons to be learned or just a coincidence?

verfasst von: Mirea Hancevic, Hrvoje Bilic, Barbara Sitas, Gordana Pavlisa, Fran Borovecki, Ivana Munitic, Ervina Bilic

Erschienen in: Neurological Sciences | Ausgabe 6/2019

Einloggen, um Zugang zu erhalten

Abstract

ALS is the most frequent motor neuron disorder in adults with suggested complex relationship regarding gender. Studies investigating ALS and hormones have provided varying results. ALS onset during pregnancy is uncommon and pregnancy after the ALS symptom onset is even rarer. We present three patients with the onset of ALS symptoms before or during pregnancy and propose a putative disease modifying mechanism leading to attenuation of disease progression that we observed during the pregnancies.
Literatur
1.
Zurück zum Zitat del Aguila MA, Longstreth WT, McGuire V, Koepsell TD, van Belle G (2003) Prognosis in amyotrophic lateral sclerosis: a population-based study. Neurology 60(5):813–819CrossRef del Aguila MA, Longstreth WT, McGuire V, Koepsell TD, van Belle G (2003) Prognosis in amyotrophic lateral sclerosis: a population-based study. Neurology 60(5):813–819CrossRef
2.
Zurück zum Zitat Manjaly, Z.R., Scott, K.M., Abhinav, K., Wijesekera, L., Ganesalingam, J., Goldstein, L.H., Janssen, A., Dougherty, A., Willey, E., Stanton, B.R., Turner, M.R., Ampong, M.-A., Sakel, M., Orrell, R.W., Howard, R., Shaw, C.E., Leigh, P.N., and Al-Chalabi, A., 2010. The sex ratio in amyotrophic lateral sclerosis: a population based study. Amyotroph Lateral Scler, 11 (5), 439–442 Manjaly, Z.R., Scott, K.M., Abhinav, K., Wijesekera, L., Ganesalingam, J., Goldstein, L.H., Janssen, A., Dougherty, A., Willey, E., Stanton, B.R., Turner, M.R., Ampong, M.-A., Sakel, M., Orrell, R.W., Howard, R., Shaw, C.E., Leigh, P.N., and Al-Chalabi, A., 2010. The sex ratio in amyotrophic lateral sclerosis: a population based study. Amyotroph Lateral Scler, 11 (5), 439–442
3.
Zurück zum Zitat Blasco, H., Guennoc, A.-M., Veyrat-Durebex, C., Gordon, P.H., Andres, C.R., Camu, W., and Corcia, P., 2012. Amyotrophic lateral sclerosis: a hormonal condition? Amyotroph Lateral Scler, 13 (6), 585–588 Blasco, H., Guennoc, A.-M., Veyrat-Durebex, C., Gordon, P.H., Andres, C.R., Camu, W., and Corcia, P., 2012. Amyotrophic lateral sclerosis: a hormonal condition? Amyotroph Lateral Scler, 13 (6), 585–588
4.
Zurück zum Zitat Byrne S, Heverin M, Bede P, Elamin M, Hardiman O (2014) Fecundity in ALS. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration 15(3–4):204–206CrossRef Byrne S, Heverin M, Bede P, Elamin M, Hardiman O (2014) Fecundity in ALS. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration 15(3–4):204–206CrossRef
5.
Zurück zum Zitat Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W, Shaw PJ, Simmons Z, van den Berg LH (2017) Amyotrophic lateral sclerosis. Nat Rev Dis Primers 3:17071CrossRefPubMed Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W, Shaw PJ, Simmons Z, van den Berg LH (2017) Amyotrophic lateral sclerosis. Nat Rev Dis Primers 3:17071CrossRefPubMed
6.
Zurück zum Zitat Martínez HR, Marioni SS, Escamilla Ocañas CE, Gonzalez Garza MT, Moreno-Cuevas JE (2014) Amyotrophic lateral sclerosis in pregnancy: clinical outcome during the post-partum period after stem cell transplantation into the frontal motor cortex. Cytotherapy 16(3):402–405CrossRefPubMed Martínez HR, Marioni SS, Escamilla Ocañas CE, Gonzalez Garza MT, Moreno-Cuevas JE (2014) Amyotrophic lateral sclerosis in pregnancy: clinical outcome during the post-partum period after stem cell transplantation into the frontal motor cortex. Cytotherapy 16(3):402–405CrossRefPubMed
7.
Zurück zum Zitat Sarafov S, Doitchinova M, Karagiozova Z, Slancheva B, Dengler R, Petri S, Kollewe K (2009) Two consecutive pregnancies in early and late stage of amyotrophic lateral sclerosis. Amyotroph Lateral Scler 10(5–6):483–486CrossRefPubMed Sarafov S, Doitchinova M, Karagiozova Z, Slancheva B, Dengler R, Petri S, Kollewe K (2009) Two consecutive pregnancies in early and late stage of amyotrophic lateral sclerosis. Amyotroph Lateral Scler 10(5–6):483–486CrossRefPubMed
8.
Zurück zum Zitat Jong S, Huisman M, Sutedja N, Kooi A, Visser M, Schelhaas J, Schouw Y, Veldink J, den Berg L (2013) Endogenous female reproductive hormones and the risk of amyotrophic lateral sclerosis. J Neurol 260(2):507–512CrossRefPubMed Jong S, Huisman M, Sutedja N, Kooi A, Visser M, Schelhaas J, Schouw Y, Veldink J, den Berg L (2013) Endogenous female reproductive hormones and the risk of amyotrophic lateral sclerosis. J Neurol 260(2):507–512CrossRefPubMed
9.
Zurück zum Zitat Rooney JPK, Visser AE, D’Ovidio F, Vermeulen R, Beghi E, Chio A, Veldink JH, Logroscino G, van den Berg LH, Hardiman O (2017) A case-control study of hormonal exposures as etiologic factors for ALS in women: euro-MOTOR. Neurology 89(12):1283–1290CrossRefPubMed Rooney JPK, Visser AE, D’Ovidio F, Vermeulen R, Beghi E, Chio A, Veldink JH, Logroscino G, van den Berg LH, Hardiman O (2017) A case-control study of hormonal exposures as etiologic factors for ALS in women: euro-MOTOR. Neurology 89(12):1283–1290CrossRefPubMed
10.
Zurück zum Zitat Nakamizo T, Urushitani M, Inoue R, Shinohara A, Sawada H, Honda K, Kihara T, Akaike A, Shimohama S (2000) Protection of cultured spinal motor neurons by estradiol. Neuroreport 11(16):3493–3497CrossRefPubMed Nakamizo T, Urushitani M, Inoue R, Shinohara A, Sawada H, Honda K, Kihara T, Akaike A, Shimohama S (2000) Protection of cultured spinal motor neurons by estradiol. Neuroreport 11(16):3493–3497CrossRefPubMed
11.
Zurück zum Zitat Robinson DP, Klein SL (2012) Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis. Horm Behav 62(3):263–271CrossRefPubMedPubMedCentral Robinson DP, Klein SL (2012) Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis. Horm Behav 62(3):263–271CrossRefPubMedPubMedCentral
13.
14.
Zurück zum Zitat Confavreux C, Hutchinson M, Hours MM, Cortinovis-Tourniaire P, Moreau T (1998) Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in multiple sclerosis Group. N Engl J Med 339(5):285–291CrossRefPubMed Confavreux C, Hutchinson M, Hours MM, Cortinovis-Tourniaire P, Moreau T (1998) Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in multiple sclerosis Group. N Engl J Med 339(5):285–291CrossRefPubMed
15.
Zurück zum Zitat Zhao W, Beers DR, Liao B, Henkel JS, Appel SH (2012) Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms. Neurobiol Dis 48(3):418–428CrossRefPubMedPubMedCentral Zhao W, Beers DR, Liao B, Henkel JS, Appel SH (2012) Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms. Neurobiol Dis 48(3):418–428CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Beers DR, Zhao W, Wang J, Zhang X, Wen S, Neal D, Thonhoff JR, Alsuliman AS, Shpall EJ, Rezvani K, Appel SH (2017) ALS patients’ regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity. JCI Insight 2(5):e89530CrossRefPubMedPubMedCentral Beers DR, Zhao W, Wang J, Zhang X, Wen S, Neal D, Thonhoff JR, Alsuliman AS, Shpall EJ, Rezvani K, Appel SH (2017) ALS patients’ regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity. JCI Insight 2(5):e89530CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Sar M, Stumpf WE (1977) Androgen concentration in motor neurons of cranial nerves and spinal cord. Science (New York, NY) 197(4298):77–79CrossRef Sar M, Stumpf WE (1977) Androgen concentration in motor neurons of cranial nerves and spinal cord. Science (New York, NY) 197(4298):77–79CrossRef
18.
Zurück zum Zitat Waragai M, Yamada T, Moroo I (1993) [The distribution of androgen receptor like protein in the central nervous system of rat and human medulla and spinal cord–immunohistochemical study]. No To Shinkei 45(7):661–667PubMed Waragai M, Yamada T, Moroo I (1993) [The distribution of androgen receptor like protein in the central nervous system of rat and human medulla and spinal cord–immunohistochemical study]. No To Shinkei 45(7):661–667PubMed
19.
Zurück zum Zitat Male hypogonadism (2017) Springer Berlin Heidelberg, New York, NY Male hypogonadism (2017) Springer Berlin Heidelberg, New York, NY
20.
Zurück zum Zitat Zhang T, Wu Y-C, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang H-Y, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim JK, Shorter J, Ong S-E, Leung AKL, Wang J (2018) FUS regulates activity of microRNA-mediated gene silencing. Mol Cell 69(5):787–801.e8CrossRefPubMedPubMedCentral Zhang T, Wu Y-C, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang H-Y, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim JK, Shorter J, Ong S-E, Leung AKL, Wang J (2018) FUS regulates activity of microRNA-mediated gene silencing. Mol Cell 69(5):787–801.e8CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Yamaguchi A, Takanashi K (2016) FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription. Sci Rep 6(1) Yamaguchi A, Takanashi K (2016) FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription. Sci Rep 6(1)
22.
Zurück zum Zitat Amato MP, Bertolotto A, Brunelli R, Cavalla P, Goretti B, Marrosu MG, Patti F, Pozzilli C, Provinciali L, Rizzo N, Strobelt N, Tedeschi G, Trojano M, Comi G (2017 Oct) Management of pregnancy-related issues in multiple sclerosis patients: the need for an interdisciplinary approach. Neurol Sci 38(10):1849–1858CrossRefPubMed Amato MP, Bertolotto A, Brunelli R, Cavalla P, Goretti B, Marrosu MG, Patti F, Pozzilli C, Provinciali L, Rizzo N, Strobelt N, Tedeschi G, Trojano M, Comi G (2017 Oct) Management of pregnancy-related issues in multiple sclerosis patients: the need for an interdisciplinary approach. Neurol Sci 38(10):1849–1858CrossRefPubMed
23.
Zurück zum Zitat Bammann BL, Coulam CB, Jiang NS (1980) Total and free testosterone during pregnancy. Am J Obstet Gynecol 137(3):293–298CrossRefPubMed Bammann BL, Coulam CB, Jiang NS (1980) Total and free testosterone during pregnancy. Am J Obstet Gynecol 137(3):293–298CrossRefPubMed
24.
Zurück zum Zitat Ysrraelit MC, Correale J (2019 Jan) Impact of sex hormones on immune function and multiple sclerosis development. Immunology 156(1):9–22CrossRefPubMed Ysrraelit MC, Correale J (2019 Jan) Impact of sex hormones on immune function and multiple sclerosis development. Immunology 156(1):9–22CrossRefPubMed
Metadaten
Titel
Attenuation of ALS progression during pregnancy—lessons to be learned or just a coincidence?
verfasst von
Mirea Hancevic
Hrvoje Bilic
Barbara Sitas
Gordana Pavlisa
Fran Borovecki
Ivana Munitic
Ervina Bilic
Publikationsdatum
11.02.2019
Verlag
Springer International Publishing
Erschienen in
Neurological Sciences / Ausgabe 6/2019
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-019-03748-z

Weitere Artikel der Ausgabe 6/2019

Neurological Sciences 6/2019 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.