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Current Clinical Microbiology Reports

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01.03.2018 | Recent Developments in Anti-viral Vaccines (K Kousoulas and P Rider, Section Editors)

Attenuation of Viruses by Large-Scale Recoding of their Genomes: the Selection Is Always Biased

verfasst von: Nikolaus Osterrieder, Dusan Kunec

Erschienen in: Current Clinical Microbiology Reports | Ausgabe 1/2018

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Abstract

Purpose of Review

This review summarizes the current understanding of virus attenuation by large-scale recoding of viral genomes and discusses what would ultimately be necessary for construction of better and safer live modified virus vaccines.

Recent Findings

It has been shown that codon and codon pair deoptimization are rapid and robust methods that can be used for the development of attenuated vaccine candidates. The viruses attenuated by large-scale recoding have the added value that they are extremely genetically stable. However, the exact mechanisms that lead to viral attenuation by recoding are yet to be determined.

Summary

While the advantages of large-scale recoding (speed, simplicity, potency, and universal applicability) have been known for more than a decade, this approach has been only inadequately explored and the attention was focused on a limited number of RNA viruses. Attenuation of viruses by large-scale recoding should be explored to combat known and future viral threats.

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Titel: Attenuation of Viruses by Large-Scale Recoding of their Genomes: the Selection Is Always Biased
verfasst von: Nikolaus Osterrieder
Dusan Kunec
Publikationsdatum: 01.03.2018
Verlag: Springer International Publishing
Erschienen in: Current Clinical Microbiology Reports / Ausgabe 1/2018
Elektronische ISSN: 2196-5471
DOI: https://doi.org/10.1007/s40588-018-0080-3

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Attenuation of Viruses by Large-Scale Recoding of their Genomes: the Selection Is Always Biased