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Journal of Neurology
Erschienen in:

29.03.2024 | Original Communication

Atypical Alzheimer’s disease: new insights into an overlapping spectrum between the language and visual variants

verfasst von: Neha Atulkumar Singh, Jonathan Graff-Radford, Mary M. Machulda, Arenn F. Carlos, Christopher G. Schwarz, Matthew L. Senjem, Clifford R. Jack Jr., Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell

Erschienen in: Journal of Neurology | Ausgabe 6/2024

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Abstract

Overlap between language and visual variants of atypical Alzheimer’s disease (AD) has been reported. However, the extent, frequency of overlap, and its neuroanatomical underpinnings remain unclear. Eighty-two biomarker-confirmed AD patients who presented with either predominant language (n = 34) or visuospatial/perceptual (n = 48) deficits underwent detailed clinical examinations, MRI, and [18F]flortaucipir-PET. Subgroups were defined based on language/visual testing and patterns of volume loss and tau uptake were assessed. 28% of the language group had visual dysfunction (marked in 8%), and 47% of the visual group had language impairment (marked in 26%). Progressive involvement of the parieto-occipital and frontal lobes was noted with greater visual impairment in the language group, and greater left parieto-temporal and frontal involvement with worsening language impairment in the visual group. Only 25% of our cohort showed a pure language or visual presentation, highlighting the high frequency of syndromic overlap in atypical AD and the diagnostic challenge of categorical phenotyping.
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Metadaten
Titel
Atypical Alzheimer’s disease: new insights into an overlapping spectrum between the language and visual variants
verfasst von
Neha Atulkumar Singh
Jonathan Graff-Radford
Mary M. Machulda
Arenn F. Carlos
Christopher G. Schwarz
Matthew L. Senjem
Clifford R. Jack Jr.
Val J. Lowe
Keith A. Josephs
Jennifer L. Whitwell
Publikationsdatum
29.03.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Neurology / Ausgabe 6/2024
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-024-12297-1

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