A 67-year-old HIV-infected man presented with hyperkeratotic lesions on the hands and nails (Fig. 1a, b). He had a history of HIV-associated encephalopathy with persistent cognitive and motor deficits. HIV seropositivity was discovered in 1998 (CDC Stage C3). The patient had undetectable HIV load and CD4 count = 166/mmc load, following a PI-based therapy.
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