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27.01.2022 | Research Article

Auditory Behavior in Adult-Blinded Mice

verfasst von: Ye-Hyun Kim, Katrina M. Schrode, James Engel, Sergio Vicencio-Jimenez, Gabriela Rodriguez, Hey-Kyoung Lee, Amanda M. Lauer

Erschienen in: Journal of the Association for Research in Otolaryngology | Ausgabe 2/2022

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Abstract

Cross-modal plasticity occurs when the function of remaining senses is enhanced following deprivation or loss of a sensory modality. Auditory neural responses are enhanced in the auditory cortex, including increased sensitivity and frequency selectivity, following short-term visual deprivation in adult mice (Petrus et al. Neuron 81:664–673, 2014). Whether or not these visual deprivation–induced neural changes translate into improved auditory perception and performance remains unclear. As an initial investigation of the effects of adult visual deprivation on auditory behaviors, CBA/CaJ mice underwent binocular enucleation at 3–4 weeks old and were tested on a battery of learned behavioral tasks, acoustic startle response (ASR), and prepulse inhibition (PPI) tests beginning at least 2 weeks after the enucleation procedure. Auditory brain stem responses (ABRs) were also measured to screen for potential effects of visual deprivation on non-behavioral hearing function. Control and enucleated mice showed similar tone detection sensitivity and frequency discrimination in a conditioned lick suppression test. Both groups showed normal reactivity to sound as measured by ASR in a quiet background. However, when startle-eliciting stimuli were presented in noise, enucleated mice showed decreased ASR amplitude relative to controls. Control and enucleated mice displayed no significant differences in ASR habituation, PPI tests, or ABR thresholds, or wave morphology. Our findings suggest that while adult-onset visual deprivation induces cross-modal plasticity at the synaptic and circuit levels, it does not substantially influence simple auditory behavioral performance.

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Titel: Auditory Behavior in Adult-Blinded Mice
verfasst von: Ye-Hyun Kim
Katrina M. Schrode
James Engel
Sergio Vicencio-Jimenez
Gabriela Rodriguez
Hey-Kyoung Lee
Amanda M. Lauer
Publikationsdatum: 27.01.2022
Verlag: Springer US
Erschienen in: Journal of the Association for Research in Otolaryngology / Ausgabe 2/2022
Print ISSN: 1525-3961
Elektronische ISSN: 1438-7573
DOI: https://doi.org/10.1007/s10162-022-00835-5

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Auditory Behavior in Adult-Blinded Mice

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