Anzeige
Erschienen in:
01.04.2018 | Original Article
Auto strain ratio system for the quality control of breast strain elastography
Erschienen in: Journal of Medical Ultrasonics | Ausgabe 2/2018
Einloggen, um Zugang zu erhaltenAbstract
Purpose
To determine the reproducibility, accuracy, and quantitative values of the auto strain ratio system (ASRS)—a newly developed strain elastography-based program.
Materials and methods
First, the accuracy of ASRS was verified using a breast phantom. A prospective clinical study was then performed in patients. Two hundred and one women (mean age 52.4 years ± SD 14.5) with 232 breast lesions (177 benign and 55 malignant) were enrolled in this study. We assessed the correlation between ASRS and manual strain ratio (MSR), calculating the diagnostic performance to determine the cut-off. The area under the receiver operating characteristic curve (AUC) was calculated.
Results
ASRS was strongly correlated with the subtle differences in phantom stiffness (R = 0.87). In the clinical study, there was a significant correlation between MSR and ASRS with R = 0.79 (P < 0.001). ASRS (cut-off = 3.9) had a sensitivity of 81.8%, specificity of 88.7%, accuracy of 87.1%, positive predictive value of 69.2%, and negative predictive value of 94%. The AUC of ASRS was 0.89.
Conclusion
The findings from this study have demonstrated that it is possible to quantify strain elastography and control its accuracy. ASRS is expected to contribute to the standardization of breast elastography.