Erschienen in:
19.11.2021 | Research Letter
Autoantibody reactivity profile of primary autoimmune hypophysitis patients: preliminary results
verfasst von:
Sabrina Chiloiro, Ettore Domenico Capoluongo, Flavia Angelini, Feliciana Mariotti, Giuseppe Grande, Egidio Stigliano, Federica Vincenzoni, Antonio Bianchi, Antonella Giampietro, Domenico Milardi, Tommaso Tartaglione, Andrea Urbani, Alfredo Pontecorvi, Laura De Marinis, Giovanni Di Zenzo
Erschienen in:
Endocrine
|
Ausgabe 1/2022
Einloggen, um Zugang zu erhalten
Excerpt
Primary autoimmune hypophysitis (PAH) is a complex and an emerging disorder [
1]. PAH is considered an autoimmune disease, as the pituitary gland typically shows an inflammatory infiltration with CD4+ and CD8+ lymphocytes, granulocytes, and monocytes/macrophages [
2,
3]. Moreover, a high prevalence of DQ8 and DR54 human leukocyte antigen (HLA) haplotypes were reported in PAH [
4,
5]. Several possible PAH antigens have been described, as alpha-enolase, proopiomelanocortin, growth hormone (GH), corticotroph-specific transcription factor, pituitary gland 1a- and 2-specific factor, and rabphilin-3A [
6‐
10]. We aimed to investigate the humoral autoimmune response in our monocentric series of PAH patients, for increasing the knowledge on PAH pathogenesis and the set-up of a reliable diagnostic approach. …
