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Erschienen in: Clinical Journal of Gastroenterology 3/2016

12.05.2016 | Case Report

Autoimmune hepatitis following drug-induced liver injury in an elderly patient

verfasst von: Junichiro Kumagai, Tatsuo Kanda, Shin Yasui, Yuki Haga, Reina Sasaki, Masato Nakamura, Shuang Wu, Shingo Nakamoto, Makoto Arai, Yotaro Iino, Osamu Yokosuka

Erschienen in: Clinical Journal of Gastroenterology | Ausgabe 3/2016

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Abstract

We describe a case of autoimmune hepatitis (AIH) that may have occurred following drug-induced liver injury with camostat mesilate and/or benzbromarone in an elderly patient. The patient’s liver biopsy showed chronic active hepatitis and autoimmune hepatitis. Stopping the use of these drugs did not lead to complete remission, but the use of a low dose of corticosteroids completely cured his liver dysfunction. In the present case, liver dysfunction was caused by an autoimmune mechanism. Special attention should be paid to idiopathic AIH and drug-induced AIH in elderly patients.
Literatur
2.
Zurück zum Zitat Scully LJ, Clarke D, Barr RJ. Diclofenac induced hepatitis. 3 cases with features of autoimmune chronic active hepatitis. Dig Dis Sci. 1993;38:744–51.CrossRefPubMed Scully LJ, Clarke D, Barr RJ. Diclofenac induced hepatitis. 3 cases with features of autoimmune chronic active hepatitis. Dig Dis Sci. 1993;38:744–51.CrossRefPubMed
3.
Zurück zum Zitat Kanda T, Yokosuka O, Tada M, et al. N-nitroso-fenfluramine hepatotoxicity resembling chronic hepatitis. J Gastroenterol Hepatol. 2003;18:999–1000.CrossRefPubMed Kanda T, Yokosuka O, Tada M, et al. N-nitroso-fenfluramine hepatotoxicity resembling chronic hepatitis. J Gastroenterol Hepatol. 2003;18:999–1000.CrossRefPubMed
4.
Zurück zum Zitat Naito A, Terada J, Tanabe N, et al. Autoimmune hepatitis in a patient with pulmonary arterial hypertension treated with endothelin receptor antagonists. Intern Med. 2014;53:771–5.CrossRefPubMed Naito A, Terada J, Tanabe N, et al. Autoimmune hepatitis in a patient with pulmonary arterial hypertension treated with endothelin receptor antagonists. Intern Med. 2014;53:771–5.CrossRefPubMed
5.
Zurück zum Zitat Hochman JA, Woodard SA, Cohen MB. Exacerbation of autoimmune hepatitis: another hepatotoxic effect of pemoline therapy. Pediatrics. 1998;101:106–8.CrossRefPubMed Hochman JA, Woodard SA, Cohen MB. Exacerbation of autoimmune hepatitis: another hepatotoxic effect of pemoline therapy. Pediatrics. 1998;101:106–8.CrossRefPubMed
6.
Zurück zum Zitat Hisamochi A, Kage M, Ide T, et al. An analysis of drug-induced liver injury, which showed histological findings similar to autoimmune hepatitis. J Gastroenterol. 2015 [Epub ahead of print] Hisamochi A, Kage M, Ide T, et al. An analysis of drug-induced liver injury, which showed histological findings similar to autoimmune hepatitis. J Gastroenterol. 2015 [Epub ahead of print]
7.
Zurück zum Zitat van der Klauw MM, Houtman PM, Stricker BH, Spoelstra P. Hepatic injury caused by benzbromarone. J Hepatol. 1994;20:376–9.CrossRefPubMed van der Klauw MM, Houtman PM, Stricker BH, Spoelstra P. Hepatic injury caused by benzbromarone. J Hepatol. 1994;20:376–9.CrossRefPubMed
8.
Zurück zum Zitat Wagayama H, Shiraki K, Sugimoto K, et al. Fatal fulminant hepatic failure associated with benzbromarone. J Hepatol. 2000;32:874.CrossRefPubMed Wagayama H, Shiraki K, Sugimoto K, et al. Fatal fulminant hepatic failure associated with benzbromarone. J Hepatol. 2000;32:874.CrossRefPubMed
9.
Zurück zum Zitat Arai M, Yokosuka O, Fujiwara K, et al. Fulminant hepatic failure associated with benzbromarone treatment: a case report. J Gastroenterol Hepatol. 2002;17:625–6.CrossRefPubMed Arai M, Yokosuka O, Fujiwara K, et al. Fulminant hepatic failure associated with benzbromarone treatment: a case report. J Gastroenterol Hepatol. 2002;17:625–6.CrossRefPubMed
10.
Zurück zum Zitat Babany G, Larrey D, Pessayre D, et al. Chronic active hepatitis caused by benzarone. J Hepatol. 1987;5:332–5.CrossRefPubMed Babany G, Larrey D, Pessayre D, et al. Chronic active hepatitis caused by benzarone. J Hepatol. 1987;5:332–5.CrossRefPubMed
11.
Zurück zum Zitat Kaufmann P, Török M, Hänni A, et al. Mechanisms of benzarone and benzbromarone-induced hepatic toxicity. Hepatology. 2005;41:925–35.CrossRefPubMed Kaufmann P, Török M, Hänni A, et al. Mechanisms of benzarone and benzbromarone-induced hepatic toxicity. Hepatology. 2005;41:925–35.CrossRefPubMed
13.
Zurück zum Zitat Kanda T, Yokosuka O, Fujiwara K, et al. Fulminant hepatic failure associated with triazolam. Dig Dis Sci. 2002;47:1111–4.CrossRefPubMed Kanda T, Yokosuka O, Fujiwara K, et al. Fulminant hepatic failure associated with triazolam. Dig Dis Sci. 2002;47:1111–4.CrossRefPubMed
14.
Zurück zum Zitat Ichida F, Tsuji T, Omata M, et al. New Inuyama classification; new criteria for histological assessment of chronic hepatitis. Int Hepatol Commun. 1996;6:112–9.CrossRef Ichida F, Tsuji T, Omata M, et al. New Inuyama classification; new criteria for histological assessment of chronic hepatitis. Int Hepatol Commun. 1996;6:112–9.CrossRef
15.
Zurück zum Zitat Alvarez F, Berg PA, Bianchi FB, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31:929–38.CrossRefPubMed Alvarez F, Berg PA, Bianchi FB, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31:929–38.CrossRefPubMed
16.
Zurück zum Zitat Hennes EM, Zeniya M, Czaja AJ, et al. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology. 2008;48:169–76.CrossRefPubMed Hennes EM, Zeniya M, Czaja AJ, et al. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology. 2008;48:169–76.CrossRefPubMed
17.
Zurück zum Zitat Takikawa H, Onji M, Takamori Y, et al. Proposal of diagnostic criteria of drug induced hepatic injury in DDW-J2004 workshop. Kanzo (in Japanese). 2005;46:85–90. Takikawa H, Onji M, Takamori Y, et al. Proposal of diagnostic criteria of drug induced hepatic injury in DDW-J2004 workshop. Kanzo (in Japanese). 2005;46:85–90.
18.
Zurück zum Zitat Kuo CF, Yu KH, Luo SF, et al. Gout and risk of non-alcoholic fatty liver disease. Scand J Rheumatol. 2010;39:466–71.CrossRefPubMed Kuo CF, Yu KH, Luo SF, et al. Gout and risk of non-alcoholic fatty liver disease. Scand J Rheumatol. 2010;39:466–71.CrossRefPubMed
20.
Zurück zum Zitat Tandra S, Yeh MM, Brunt EM, et al. Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease. J Hepatol. 2011;55:654–9.CrossRefPubMed Tandra S, Yeh MM, Brunt EM, et al. Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease. J Hepatol. 2011;55:654–9.CrossRefPubMed
22.
Zurück zum Zitat Björnsson E, Talwalkar J, Treeprasertsuk S, et al. Drug-induced autoimmune hepatitis: clinical characteristics and prognosis. Hepatology. 2010;51:2040–8.CrossRefPubMed Björnsson E, Talwalkar J, Treeprasertsuk S, et al. Drug-induced autoimmune hepatitis: clinical characteristics and prognosis. Hepatology. 2010;51:2040–8.CrossRefPubMed
23.
Zurück zum Zitat Abe M, Mashiba T, Zeniya M, et al. Present status of autoimmune hepatitis in Japan: a nationwide survey. J Gastroenterol. 2011;46:1136–41.CrossRefPubMed Abe M, Mashiba T, Zeniya M, et al. Present status of autoimmune hepatitis in Japan: a nationwide survey. J Gastroenterol. 2011;46:1136–41.CrossRefPubMed
Metadaten
Titel
Autoimmune hepatitis following drug-induced liver injury in an elderly patient
verfasst von
Junichiro Kumagai
Tatsuo Kanda
Shin Yasui
Yuki Haga
Reina Sasaki
Masato Nakamura
Shuang Wu
Shingo Nakamoto
Makoto Arai
Yotaro Iino
Osamu Yokosuka
Publikationsdatum
12.05.2016
Verlag
Springer Japan
Erschienen in
Clinical Journal of Gastroenterology / Ausgabe 3/2016
Print ISSN: 1865-7257
Elektronische ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-016-0648-5

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