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Journal of Clinical Immunology

Erschienen in:

01.05.2008

Autoimmune Manifestations in Common Variable Immunodeficiency

verfasst von: C. Cunningham-Rundles

Erschienen in: Journal of Clinical Immunology | Sonderheft 1/2008

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Abstract

Introduction

About 20% of subjects with common variable immune deficiency (CVID) develop an autoimmune complication, most often immune thrombocytopenia or hemolytic anemia. While the pathogenesis of autoreactivity is unknown for CVID subjects in general, and to a greater extent in those with autoimmunity, there is a loss of switched memory B cells.

Discussion

About 7–8% of CVID subjects have mutations in the transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI), a significant association with this immune defect, although the same mutations may be found in normal relatives and rarely in healthy blood donors. In addition to generalized B cell dysfunction, defective elimination of autoimmune B cells has been demonstrated.

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Titel: Autoimmune Manifestations in Common Variable Immunodeficiency
verfasst von: C. Cunningham-Rundles
Publikationsdatum: 01.05.2008
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe Sonderheft 1/2008
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-008-9182-7

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Autoimmune Manifestations in Common Variable Immunodeficiency

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