2018 | OriginalPaper | Buchkapitel
Erschienen in:
Autoimmunerkrankungen in der Neurologie
Die idiopathischen inflammatorischen Myopathien (IIM) umfassen die Dermatomyositis (DM), die immunogen nekrotisierenden Myopathien (INM), die Antisynthetasesyndrom(ASS)-assoziierte Myositis, die sporadische Einschlusskörpermyositis (sIBM) und die Polymyositis (PM). Dieses Kapitel stellt die Klinik, aktuelle serologische Autoantikörperprofile, EMG-Befunde, die Bildgebung und die Muskelbiopsiediagnostik dar. Dazu werden die aktuellen Behandlungsoptionen zusammengefasst. Differenzialdiagnostisch wichtige Erkrankungen werden einbezogen. Chronische Myositiden müssen ggf. bioptisch und molekulargenetisch von hereditären Myopathien abgegrenzt werden. Wichtigste Neuerungen des diagnostischen Vorgehens und Informationen zum Krankheitsverlauf werden dargestellt.
Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten
Sie möchten Zugang zu diesem Inhalt erhalten? Dann informieren Sie sich jetzt über unsere Produkte:
Anzeige
Zurück zum Zitat Allenbach Y, Benveniste O (2013) Acquired necrotizing myopathies. Curr Opin Neurol 26:554–560 CrossRefPubMed Allenbach Y, Benveniste O (2013) Acquired necrotizing myopathies. Curr Opin Neurol 26:554–560
CrossRefPubMed
Zurück zum Zitat Allenbach Y, Benveniste O (2014) Autoantibody profile in myositis. Rev Med Interne 35:437–443 CrossRefPubMed Allenbach Y, Benveniste O (2014) Autoantibody profile in myositis. Rev Med Interne 35:437–443
CrossRefPubMed
Zurück zum Zitat Allenbach Y, Leroux G, Suarez-Calvet X, Preusse C, Gallardo E, Hervier B, Rigolet A, Hie M, Pehl D, Limal N, Hufnagl P, Zerbe N, Meyer A, Aouizerate J, Uzunhan Y, Maisonobe T, Goebel HH, Benveniste O, Stenzel W (2016a) Dermatomyositis with or without anti-melanoma differentiation-associated gene 5 antibodies: common interferon signature but distinct NOS2 expression. Am J Pathol 186:691–700 CrossRefPubMed Allenbach Y, Leroux G, Suarez-Calvet X, Preusse C, Gallardo E, Hervier B, Rigolet A, Hie M, Pehl D, Limal N, Hufnagl P, Zerbe N, Meyer A, Aouizerate J, Uzunhan Y, Maisonobe T, Goebel HH, Benveniste O, Stenzel W (2016a) Dermatomyositis with or without anti-melanoma differentiation-associated gene 5 antibodies: common interferon signature but distinct NOS2 expression. Am J Pathol 186:691–700
CrossRefPubMed
Zurück zum Zitat Allenbach Y, Keraen J, Bouvier AM, Jooste V, Champtiaux N, Hervier B, Schoindre Y, Rigolet A, Gilardin L, Musset L, Charuel JL, Boyer O, Jouen F, Drouot L, Martinet J, Stojkovic T, Eymard B, Laforet P, Behin A, Salort-Campana E, Fain O, Meyer A, Schleinitz N, Mariampillai K, Grados A, Benveniste O (2016b) High risk of cancer in autoimmune necrotizing myopathies: usefulness of myositis specific antibody. Brain 139:2131–2517 CrossRefPubMed Allenbach Y, Keraen J, Bouvier AM, Jooste V, Champtiaux N, Hervier B, Schoindre Y, Rigolet A, Gilardin L, Musset L, Charuel JL, Boyer O, Jouen F, Drouot L, Martinet J, Stojkovic T, Eymard B, Laforet P, Behin A, Salort-Campana E, Fain O, Meyer A, Schleinitz N, Mariampillai K, Grados A, Benveniste O (2016b) High risk of cancer in autoimmune necrotizing myopathies: usefulness of myositis specific antibody. Brain 139:2131–2517
CrossRefPubMed
Zurück zum Zitat Benveniste O, Guiguet M, Freebody J, Dubourg O, Squier W, Maisonobe T, Stojkovic T, Leite MI, Allenbach Y, Herson S, Brady S, Eymard B, Hilton-Jones D (2011) Long-term observational study of sporadic inclusion body myositis. Brain 134:3176–3184 CrossRefPubMed Benveniste O, Guiguet M, Freebody J, Dubourg O, Squier W, Maisonobe T, Stojkovic T, Leite MI, Allenbach Y, Herson S, Brady S, Eymard B, Hilton-Jones D (2011) Long-term observational study of sporadic inclusion body myositis. Brain 134:3176–3184
CrossRefPubMed
Zurück zum Zitat Benveniste O, Stenzel W, Hilton-Jones D, Sandri M, Boyer O, Engelen BG van (2015) Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken. Acta Neuropathol 129:611–624 CrossRefPubMedPubMedCentral Benveniste O, Stenzel W, Hilton-Jones D, Sandri M, Boyer O, Engelen BG van (2015) Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken. Acta Neuropathol 129:611–624
CrossRefPubMedPubMedCentral
Zurück zum Zitat Bird HA, Esselintex W, Dixon ASJ, Moval AG, Wood PHN (1979) An evaluation of criteria for polymyalgia rheumatica. Ann Rheum 38:434–439 CrossRef Bird HA, Esselintex W, Dixon ASJ, Moval AG, Wood PHN (1979) An evaluation of criteria for polymyalgia rheumatica. Ann Rheum 38:434–439
CrossRef
Zurück zum Zitat Bohan A, Peter JB (1975a) Polymyositis and dermatomyositis (second of two parts). N Engl J Med 292:403–407 CrossRefPubMed Bohan A, Peter JB (1975a) Polymyositis and dermatomyositis (second of two parts). N Engl J Med 292:403–407
CrossRefPubMed
Zurück zum Zitat Bohan A, Peter JB (1975b) Polymyositis and dermatomyositis (first of two parts). N Engl J Med 292:344–347 CrossRefPubMed Bohan A, Peter JB (1975b) Polymyositis and dermatomyositis (first of two parts). N Engl J Med 292:344–347
CrossRefPubMed
Zurück zum Zitat De Bleecker JL, De Paepe B, Aronica E, Visser M de, Amato A, Benveniste O, De Bleecker J, Boer O de, Dimachkie M, Gherardi R, Goebel HH, Hilton-Jones D, Holton J, Lundberg IE, Mammen A, Mastaglia F, Nishino I, Rushing E, Schroder HD, Selcen D, Stenzel W (2015) 205th ENMC International Workshop: Pathology diagnosis of idiopathic inflammatory myopathies part II 28–30 March 2014, Naarden, The Netherlands. Neuromuscul Disord 25:268–272 CrossRefPubMed De Bleecker JL, De Paepe B, Aronica E, Visser M de, Amato A, Benveniste O, De Bleecker J, Boer O de, Dimachkie M, Gherardi R, Goebel HH, Hilton-Jones D, Holton J, Lundberg IE, Mammen A, Mastaglia F, Nishino I, Rushing E, Schroder HD, Selcen D, Stenzel W (2015) 205th ENMC International Workshop: Pathology diagnosis of idiopathic inflammatory myopathies part II 28–30 March 2014, Naarden, The Netherlands. Neuromuscul Disord 25:268–272
CrossRefPubMed
Zurück zum Zitat Hengstman GJ, Laak HJ ter, Vree Egberts WT, Lundberg IE, Moutsopoulos HM, Vencovsky J, Doria A, Mosca M, Venrooij WJ van, Engelen BG van (2006) Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis 65:1635–1638 CrossRefPubMedPubMedCentral Hengstman GJ, Laak HJ ter, Vree Egberts WT, Lundberg IE, Moutsopoulos HM, Vencovsky J, Doria A, Mosca M, Venrooij WJ van, Engelen BG van (2006) Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis 65:1635–1638
CrossRefPubMedPubMedCentral
Zurück zum Zitat Hida A, Yamashita T, Hosono Y, Inoue M, Kaida K, Kadoya M, Miwa Y, Yajima N, Maezawa R, Arai S, Kurasawa K, Ito K, Shimada H, Iwanami T, Sonoo M, Hatanaka Y, Murayama S, Uchibori A, Chiba A, Aizawa H, Momoo T, Nakae Y, Sakurai Y, Shiio Y, Hashida H, Yoshizawa T, Sakiyama Y, Oda A, Inoue K, Takeuchi S, Iwata NK, Date H, Masuda N, Mikata T, Motoyoshi Y, Uesaka Y, Maeda MH, Nakashima R, Tsuji S, Kwak S, Mimori T, Shimizu J (2016) Anti-TIF1-gamma antibody and cancer-associated myositis: a clinicohistopathologic study. Neurology 87:299–308 CrossRefPubMed Hida A, Yamashita T, Hosono Y, Inoue M, Kaida K, Kadoya M, Miwa Y, Yajima N, Maezawa R, Arai S, Kurasawa K, Ito K, Shimada H, Iwanami T, Sonoo M, Hatanaka Y, Murayama S, Uchibori A, Chiba A, Aizawa H, Momoo T, Nakae Y, Sakurai Y, Shiio Y, Hashida H, Yoshizawa T, Sakiyama Y, Oda A, Inoue K, Takeuchi S, Iwata NK, Date H, Masuda N, Mikata T, Motoyoshi Y, Uesaka Y, Maeda MH, Nakashima R, Tsuji S, Kwak S, Mimori T, Shimizu J (2016) Anti-TIF1-gamma antibody and cancer-associated myositis: a clinicohistopathologic study. Neurology 87:299–308
CrossRefPubMed
Zurück zum Zitat Holmgren AR, Matteson EL (2006) Lyme myositis. Arthritis Rheum 54:2697–2700 CrossRefPubMed Holmgren AR, Matteson EL (2006) Lyme myositis. Arthritis Rheum 54:2697–2700
CrossRefPubMed
Zurück zum Zitat Kang EH, Lee SJ, Ascherman DP, Lee YJ, Lee EY, Lee EB, Song YW (2016) Temporal relationship between cancer and myositis identifies two distinctive subgroups of cancers: impact on cancer risk and survival in patients with myositis. Rheumatology (Oxford) 55(9):1631–1641 CrossRef Kang EH, Lee SJ, Ascherman DP, Lee YJ, Lee EY, Lee EB, Song YW (2016) Temporal relationship between cancer and myositis identifies two distinctive subgroups of cancers: impact on cancer risk and survival in patients with myositis. Rheumatology (Oxford) 55(9):1631–1641
CrossRef
Zurück zum Zitat Leitlinie Myositis Deutsche Gesellschaft für Neurologie. https://www.dgn.org/leitlinien/3011-ll-69-ll-myositissyndrome Leitlinie Myositis Deutsche Gesellschaft für Neurologie.
https://www.dgn.org/leitlinien/3011-ll-69-ll-myositissyndrome
Zurück zum Zitat Lünemann JD, Schmidt J, Schmid D, Barthel K, Wrede A, Dalakas MC, Munz C (2007) Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis. Ann Neurol 61:476–483 CrossRefPubMed Lünemann JD, Schmidt J, Schmid D, Barthel K, Wrede A, Dalakas MC, Munz C (2007) Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis. Ann Neurol 61:476–483
CrossRefPubMed
Zurück zum Zitat Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, Zachary AA (2012) Increased frequency of DRB1*11:01 in anti-hydroxymethylglutaryl-coenzyme A reductase-associated autoimmune myopathy. Arthritis Care Res (Hoboken) 64:1233–1237 CrossRef Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, Zachary AA (2012) Increased frequency of DRB1*11:01 in anti-hydroxymethylglutaryl-coenzyme A reductase-associated autoimmune myopathy. Arthritis Care Res (Hoboken) 64:1233–1237
CrossRef
Zurück zum Zitat Meulen MF van der, Bronner IM, Hoogendijk JE, Burger H, van Venrooij WJ, Voskuyl AE, Dinant HJ, Linssen WH, Wokke JH, de Visser M (2003) Polymyositis: an overdiagnosed entity. Neurology 61:316–321 CrossRefPubMed Meulen MF van der, Bronner IM, Hoogendijk JE, Burger H, van Venrooij WJ, Voskuyl AE, Dinant HJ, Linssen WH, Wokke JH, de Visser M (2003) Polymyositis: an overdiagnosed entity. Neurology 61:316–321
CrossRefPubMed
Zurück zum Zitat Naschitz JE, Boss JH, Misselevich I, Yeshurun D, Rosner I (1996) The fasciitis-panniculitis syndromes. Clinical and pathologic features. Medicine 75:6–16 PubMed Naschitz JE, Boss JH, Misselevich I, Yeshurun D, Rosner I (1996) The fasciitis-panniculitis syndromes. Clinical and pathologic features. Medicine 75:6–16
PubMed
Zurück zum Zitat Pinal-Fernandez I, Casciola-Rosen LA, Christopher-Stine L, Corse AM, Mammen AL (2015) The prevalence of individual histopathologic features varies according to autoantibody status in muscle biopsies from patients with dermatomyositis. J Rheumatol 42:1448–1454 CrossRefPubMed Pinal-Fernandez I, Casciola-Rosen LA, Christopher-Stine L, Corse AM, Mammen AL (2015) The prevalence of individual histopathologic features varies according to autoantibody status in muscle biopsies from patients with dermatomyositis. J Rheumatol 42:1448–1454
CrossRefPubMed
Zurück zum Zitat Rose MR (2013) 188th ENMC International Workshop: Inclusion Body Myositis, 2–4 December 2011, Naarden, The Netherlands. Neuromuscul Disord 23:1044–1055 CrossRefPubMed Rose MR (2013) 188th ENMC International Workshop: Inclusion Body Myositis, 2–4 December 2011, Naarden, The Netherlands. Neuromuscul Disord 23:1044–1055
CrossRefPubMed
Zurück zum Zitat Stenzel W, Goebel HH, Aronica E (2011) Review: immune-mediated necrotizing myopathies – a heterogeneous group of diseases with specific myopathological features. Neuropathol Appl Neurobiol 38:632–646 CrossRef Stenzel W, Goebel HH, Aronica E (2011) Review: immune-mediated necrotizing myopathies – a heterogeneous group of diseases with specific myopathological features. Neuropathol Appl Neurobiol 38:632–646
CrossRef
Zurück zum Zitat Troyanov Y, Targoff IN, Payette MP, Raynauld JP, Chartier S, Goulet JR, Bourre-Tessier J, Rich E, Grodzicky T, Fritzler MJ, Joyal F, Koenig M, Senecal JL (2014) Redefining dermatomyositis: a description of new diagnostic criteria that differentiate pure dermatomyositis from overlap myositis with dermatomyositis features. Medicine (Baltimore) 93:318–332 CrossRef Troyanov Y, Targoff IN, Payette MP, Raynauld JP, Chartier S, Goulet JR, Bourre-Tessier J, Rich E, Grodzicky T, Fritzler MJ, Joyal F, Koenig M, Senecal JL (2014) Redefining dermatomyositis: a description of new diagnostic criteria that differentiate pure dermatomyositis from overlap myositis with dermatomyositis features. Medicine (Baltimore) 93:318–332
CrossRef
Zurück zum Zitat Zierz S, Jerusalem J (2014) Muskelerkrankungen, 4. Aufl. Thieme, Stuttgart Zierz S, Jerusalem J (2014) Muskelerkrankungen, 4. Aufl. Thieme, Stuttgart
- Titel
- Autoimmune Muskelerkrankungen
- DOI
- https://doi.org/10.1007/978-3-662-55530-9_4
- Autor:
-
Benedikt Schoser
- Verlag
- Springer Berlin Heidelberg
- Sequenznummer
- 4
- Kapitelnummer
- Kapitel 4
Anzeige