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16.02.2024 | Clinical Case Report

Autoimmune retinopathy in a patient with smoldering multiple myeloma: a case report

verfasst von: Zachary Bergman, Taariq Mohammed, Lisa Schocket, Rachid Aouchiche, Mary A. Johnson

Erschienen in: Documenta Ophthalmologica

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Abstract

Purpose

Multiple myeloma (MM) is a plasma cell dyscrasia leading to proliferation of monoclonal plasma cells. Ocular involvement in multiple myeloma is uncommon but can occur. The ocular manifestations of MM may include the cornea, uvea, and retinal vasculature. We present a rare case of autoimmune retinopathy associated with smoldering MM.

Case

A 76-year-old female with no significant past medical or ocular history presented with four months of worsening vision, difficulty with night driving, and loss of peripheral vision. Examination was notable for pallor of the optic nerves and vascular attenuation. Visual field testing demonstrated significant and progressive field loss in both eyes. An electroretinogram was extinguished under all conditions. Serum protein electrophoresis showed a significant elevation of IgG with an M-spike, and a subsequent bone marrow biopsy was performed showing 12.5% plasma cells, consistent with the diagnosis of MM. CAR antibody testing was positive for anti-enolase, anti-GAPDH, and anti-Rab6 antibodies, consistent with autoimmune retinopathy.

Discussion

Autoimmune retinopathy associated with MM is exceedingly rare. Management of this condition is challenging, as treatment of the underlying disease does not often lead to improvement in visual symptoms. Ultimately, visual prognosis is very poor, and both patients and clinicians should be aware of the guarded visual potential.

Conclusion

The association of autoimmune retinopathy with multiple myeloma is rare. It is crucial for physicians to be aware of such manifestations to ensure timely and appropriate diagnosis and management for patients.
Literatur
2.
Zurück zum Zitat Mordukowitz S (2016) Ocular signs of multiple myeloma. Clin Refract Optometry 27:3 Mordukowitz S (2016) Ocular signs of multiple myeloma. Clin Refract Optometry 27:3
4.
Zurück zum Zitat PA Brannan, KC Golnik, DT Hudak (2003) Cancer-associated retinopathy: the first case associated with multiple myeloma. Invest Ophthalmol Vis Sci 44(13):636 PA Brannan, KC Golnik, DT Hudak (2003) Cancer-associated retinopathy: the first case associated with multiple myeloma. Invest Ophthalmol Vis Sci 44(13):636
11.
Metadaten
Titel
Autoimmune retinopathy in a patient with smoldering multiple myeloma: a case report
verfasst von
Zachary Bergman
Taariq Mohammed
Lisa Schocket
Rachid Aouchiche
Mary A. Johnson
Publikationsdatum
16.02.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
Documenta Ophthalmologica
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-024-09965-y

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