Erschienen in:
01.05.2008
Autoimmunity in IgA Deficiency: Revisiting the Role of IgA as a Silent Housekeeper
verfasst von:
Cristina M. A. Jacob, Antonio C. Pastorino, Kristine Fahl, Magda Carneiro-Sampaio, Renato C. Monteiro
Erschienen in:
Journal of Clinical Immunology
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Sonderheft 1/2008
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Abstract
Both systemic and organ-specific autoimmune diseases are major manifestations of IgA deficiency (IgAD), the most common primary immunodeficiency. In addition, to discuss the clinical findings of IgAD patients, we proposed a hypothesis to explain the high association with autoimmune phenomena. Based on observations, interactions of monomeric IgA with FcαRI result in a partial phosphorylation of FcRγ-associated FcαRI, notably in the immunoreceptor tyrosine-based activation motif (ITAM) inducing the recruitment of the SHP-1 tyrosine phosphatase. This leads to deactivation of several activating pathways of the immune system including immunoreceptors that bear ITAM motif and ITAM-independent receptors. Consequently, inflammatory reactions and auto-immune process would be prevented.