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04.03.2019 | Stem Cell Transplantation (R Maziarz, Section Editor) | Ausgabe 2/2019 Open Access

Current Hematologic Malignancy Reports 2/2019

Autologous Haematopoietic Stem Cell Transplantation in Multiple Sclerosis: a Review of Current Literature and Future Directions for Transplant Haematologists and Oncologists

Zeitschrift:
Current Hematologic Malignancy Reports > Ausgabe 2/2019
Autoren:
Joyutpal Das, Basil Sharrack, John A. Snowden
Wichtige Hinweise
The original version of this article was revised: Modifications have been made to the 5th paragraph of the section "Efficacy", and in Table 3; Additional authors’ information has also been added as an article note in the front matter. Full information regarding the corrections made can be found in the erratum/correction for this article.
Basil Sharrack is a Member of the Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT); John A. Snowden is a Chair of the Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT).
This article is part of the Topical Collection on Stem Cell Transplantation
A correction to this article is available online at https://​doi.​org/​10.​1007/​s11899-019-00506-y.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Purpose of Review

We summarise the current development of autologous haematopoietic stem cell transplantation (AHSCT) in treating multiple sclerosis (MS) and discuss future directions for the general neurologist, transplant haematologist and oncologist.

Recent Findings

AHSCT was initially performed to treat MS over 20 years ago. Over recent years, the evidence base has grown, especially in relapsing-remitting MS (RRMS), with significant improvements in safety and efficacy through better patient selection, choice of transplant technique and increase in centre experience.

Summary

AHSCT is now a treatment option in very carefully selected patients with severe, treatment-resistant RRMS. However, it is important for transplant haematologists and oncologists to work closely with specialist MS neurologists in patient selection, during transplant and in long-term follow-up of patients. Data should be registered into international transplant registries and, ideally, patients should be enrolled on prospective clinical trials in order to build the evidence base and refine transplant techniques.

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Literatur
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